Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death‐associated protein like‐1 DAPL1 by alternative MITF splice forms

• Published in: Pigment cell and melanoma research Vol. 31; no. 3; pp. 411 - 422
• Main Authors: Ma, Xiaoyin, Hua, Jiajia, Zheng, Guoxiao, Li, Fang, Rao, Chunbao, Li, Huirong, Wang, Jing, Pan, Li, Hou, Ling
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2018
• Subjects: age‐related macular degeneration; Alternative splicing; Cell growth; Cell lines; Cell proliferation; Deoxyribonucleic acid; DNA; Epithelium; Eye diseases; Homology; Isoforms; Kinases; miRNA; MITF; pigment cell; Retina; Retinal pigment epithelium; Ribonucleic acid; RNA; MITF; pigment cell; retinal pigment epithelium; alternative splicing; age-related macular degeneration

Summary Vertebrate eye development and homoeostasis critically depend on the regulation of proliferation of cells forming the retinal pigment epithelium (RPE). Previous results indicated that the death‐associated protein like‐1 DAPL1 cell autonomously suppresses RPE proliferation in vivo and in vitr...