The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses
Background The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL‐4, IL‐5, and IL‐13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this inves...
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Published in | Allergy (Copenhagen) Vol. 72; no. 7; pp. 1081 - 1090 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
Blackwell Publishing Ltd
01.07.2017
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Abstract | Background
The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL‐4, IL‐5, and IL‐13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation.
Methods
Naïve human CD4+ T cells were short‐term activated in the presence or absence of IL‐4 and analyzed for expression of >300 cell‐surface proteins. Ex vivo‐isolated peripheral blood mononuclear cells (PBMCs) from peanut‐allergic (PA) and nonallergic subjects were stimulated (14–16 h) with peanut extract to detect peanut‐specific CD4+CD154+ T cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis.
Results
Expression analysis of >300 surface proteins enabled identification of IL‐4‐upregulated surface proteins, such as CD90, CD108, CD109, and CD200R (CD200R1). Additional analysis of in vitro‐differentiated Th0, Th1, and Th2 cultures identified CD200R as upregulated on Th2 cells. From ex vivo‐isolated PBMCs, we found high expression of CD200R on Th2 and ILC2 cells and basophils. In PA subjects, the peanut‐specific Th2 (CD154+CRTh2+) cells expressed more CD200R than the non‐allergen‐specific Th2 (CD154−CRTh2+) cells. Moreover, costaining of CD161 and CD200R identified peanut‐specific highly differentiated IL‐4+IL‐5+ Th2 cells. Finally, transcriptomic analysis revealed upregulation of CD200R in lesional skin from subjects with an extrinsic AD phenotype compared to healthy skin.
Conclusion
These results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism is as yet elusive. |
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AbstractList | Background
The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL‐4, IL‐5, and IL‐13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation.
Methods
Naïve human CD4+ T cells were short‐term activated in the presence or absence of IL‐4 and analyzed for expression of >300 cell‐surface proteins. Ex vivo‐isolated peripheral blood mononuclear cells (PBMCs) from peanut‐allergic (PA) and nonallergic subjects were stimulated (14–16 h) with peanut extract to detect peanut‐specific CD4+CD154+ T cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis.
Results
Expression analysis of >300 surface proteins enabled identification of IL‐4‐upregulated surface proteins, such as CD90, CD108, CD109, and CD200R (CD200R1). Additional analysis of in vitro‐differentiated Th0, Th1, and Th2 cultures identified CD200R as upregulated on Th2 cells. From ex vivo‐isolated PBMCs, we found high expression of CD200R on Th2 and ILC2 cells and basophils. In PA subjects, the peanut‐specific Th2 (CD154+CRTh2+) cells expressed more CD200R than the non‐allergen‐specific Th2 (CD154−CRTh2+) cells. Moreover, costaining of CD161 and CD200R identified peanut‐specific highly differentiated IL‐4+IL‐5+ Th2 cells. Finally, transcriptomic analysis revealed upregulation of CD200R in lesional skin from subjects with an extrinsic AD phenotype compared to healthy skin.
Conclusion
These results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism is as yet elusive. BACKGROUNDThe pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation.METHODSNaïve human CD4+ T cells were short-term activated in the presence or absence of IL-4 and analyzed for expression of >300 cell-surface proteins. Ex vivo-isolated peripheral blood mononuclear cells (PBMCs) from peanut-allergic (PA) and nonallergic subjects were stimulated (14-16 h) with peanut extract to detect peanut-specific CD4+ CD154+ T cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis.RESULTSExpression analysis of >300 surface proteins enabled identification of IL-4-upregulated surface proteins, such as CD90, CD108, CD109, and CD200R (CD200R1). Additional analysis of in vitro-differentiated Th0, Th1, and Th2 cultures identified CD200R as upregulated on Th2 cells. From ex vivo-isolated PBMCs, we found high expression of CD200R on Th2 and ILC2 cells and basophils. In PA subjects, the peanut-specific Th2 (CD154+ CRTh2+ ) cells expressed more CD200R than the non-allergen-specific Th2 (CD154- CRTh2+ ) cells. Moreover, costaining of CD161 and CD200R identified peanut-specific highly differentiated IL-4+ IL-5+ Th2 cells. Finally, transcriptomic analysis revealed upregulation of CD200R in lesional skin from subjects with an extrinsic AD phenotype compared to healthy skin.CONCLUSIONThese results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism is as yet elusive. The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. Naïve human CD4 T cells were short-term activated in the presence or absence of IL-4 and analyzed for expression of >300 cell-surface proteins. Ex vivo-isolated peripheral blood mononuclear cells (PBMCs) from peanut-allergic (PA) and nonallergic subjects were stimulated (14-16 h) with peanut extract to detect peanut-specific CD4 CD154 T cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis. Expression analysis of >300 surface proteins enabled identification of IL-4-upregulated surface proteins, such as CD90, CD108, CD109, and CD200R (CD200R1). Additional analysis of in vitro-differentiated Th0, Th1, and Th2 cultures identified CD200R as upregulated on Th2 cells. From ex vivo-isolated PBMCs, we found high expression of CD200R on Th2 and ILC2 cells and basophils. In PA subjects, the peanut-specific Th2 (CD154 CRTh2 ) cells expressed more CD200R than the non-allergen-specific Th2 (CD154 CRTh2 ) cells. Moreover, costaining of CD161 and CD200R identified peanut-specific highly differentiated IL-4 IL-5 Th2 cells. Finally, transcriptomic analysis revealed upregulation of CD200R in lesional skin from subjects with an extrinsic AD phenotype compared to healthy skin. These results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism is as yet elusive. Background The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. Methods Naïve human CD4+ T cells were short-term activated in the presence or absence of IL-4 and analyzed for expression of >300 cell-surface proteins. Ex vivo-isolated peripheral blood mononuclear cells (PBMCs) from peanut-allergic (PA) and nonallergic subjects were stimulated (14-16 h) with peanut extract to detect peanut-specific CD4+CD154+ T cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis. Results Expression analysis of >300 surface proteins enabled identification of IL-4-upregulated surface proteins, such as CD90, CD108, CD109, and CD200R (CD200R1). Additional analysis of in vitro-differentiated Th0, Th1, and Th2 cultures identified CD200R as upregulated on Th2 cells. From ex vivo-isolated PBMCs, we found high expression of CD200R on Th2 and ILC2 cells and basophils. In PA subjects, the peanut-specific Th2 (CD154+CRTh2+) cells expressed more CD200R than the non-allergen-specific Th2 (CD154-CRTh2+) cells. Moreover, costaining of CD161 and CD200R identified peanut-specific highly differentiated IL-4+IL-5+ Th2 cells. Finally, transcriptomic analysis revealed upregulation of CD200R in lesional skin from subjects with an extrinsic AD phenotype compared to healthy skin. Conclusion These results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism is as yet elusive. |
Author | Hansen, C. V. Juel‐Berg, N. Martel, B. C. Litman, T. Blom, L. H. Poulsen, L. K. Larsen, L. F. Christensen, M. P. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28106273$$D View this record in MEDLINE/PubMed |
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Keywords | CD154 atopic dermatitis CD200R peanut-specific Th cells Th2 |
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Snippet | Background
The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL‐4, IL‐5,... The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13.... Background The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5,... BACKGROUNDThe pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5,... |
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SubjectTerms | Allergens Allergens - immunology Allergic diseases Antigens, Surface - genetics Antigens, Surface - metabolism Atopic dermatitis Basophils - immunology Basophils - metabolism CD154 CD200R CD4 antigen CD40L protein CD90 antigen Cell surface Culture Cytokines - metabolism Dermatitis Gene Expression Helper cells Humans Hypersensitivity - genetics Hypersensitivity - immunology Hypersensitivity - metabolism Immune response Immunoglobulins Immunology Interleukin 13 Interleukin 4 Interleukin 5 Leukocytes (basophilic) Leukocytes (mononuclear) Lymphocytes Lymphocytes T Neurodegenerative diseases Pathology Peanut Hypersensitivity - genetics Peanut Hypersensitivity - immunology Peanut Hypersensitivity - metabolism peanut‐specific Th cells Peripheral blood mononuclear cells Proteins Psoriasis Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Skin diseases Surface markers T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th2 Th2 Cells - immunology Th2 Cells - metabolism Thy-1 Antigens - metabolism |
Title | The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fall.13129 https://www.ncbi.nlm.nih.gov/pubmed/28106273 https://www.proquest.com/docview/1906214818/abstract/ https://search.proquest.com/docview/1861583160 |
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