Polygenic risk score analysis of pathologically confirmed Alzheimer disease

• Published in: Annals of neurology Vol. 82; no. 2; pp. 311 - 314
• Main Authors: Escott‐Price, Valentina, Myers, Amanda J., Huentelman, Matt, Hardy, John
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2017
• Subjects: Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Area Under Curve; Genetic analysis; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; Humans; Models, Genetic; Multifactorial Inheritance; Neurodegenerative diseases; Polymorphism, Single Nucleotide - genetics; Predictive control; Risk analysis; Risk Assessment - methods

Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer disease have given area under the curve (AUC) estimates of <80%. However, these have been based on the genetic analysis of clinical case–control series. Here, we apply the same analytic approaches t...