PCV13 普及後の小児急性中耳炎に関する疫学的検討
肺炎球菌結合型ワクチン (PCV) の世界的な普及は肺炎球菌感染症への劇的効果とともに肺炎球菌自体の変化をもたらした. 肺炎球菌は急性中耳炎 (AOM) の主な起炎菌の1つであり, その動向は AOM 診療にも影響を及ぼす. われわれは, PCV 普及後の AOM の現状を明らかにするため, 2016年7月から全国調査を実施し, 小児 AOM 患者529例 (PCV 接種率97%) を対象に起炎菌, 肺炎球菌血清型, 患者背景等について検討を行った. 検出された菌はインフルエンザ菌が57%と過半数を占め, 次いで肺炎球菌26%, 黄色ブドウ球菌8%, A 群溶血性レンサ球菌3%, モラクセラ・...
Saved in:
| Published in | 日本耳鼻咽喉科学会会報 Vol. 121; no. 7; pp. 887 - 898 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本耳鼻咽喉科学会
20.07.2018
日本耳鼻咽喉科学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0030-6622 1883-0854 |
| DOI | 10.3950/jibiinkoka.121.887 |
Cover
| Abstract | 肺炎球菌結合型ワクチン (PCV) の世界的な普及は肺炎球菌感染症への劇的効果とともに肺炎球菌自体の変化をもたらした. 肺炎球菌は急性中耳炎 (AOM) の主な起炎菌の1つであり, その動向は AOM 診療にも影響を及ぼす. われわれは, PCV 普及後の AOM の現状を明らかにするため, 2016年7月から全国調査を実施し, 小児 AOM 患者529例 (PCV 接種率97%) を対象に起炎菌, 肺炎球菌血清型, 患者背景等について検討を行った. 検出された菌はインフルエンザ菌が57%と過半数を占め, 次いで肺炎球菌26%, 黄色ブドウ球菌8%, A 群溶血性レンサ球菌3%, モラクセラ・カタラーリス1%であった. 肺炎球菌の血清型は15A 型15%, 35B 型12%, 3型11%の順に多く, 13価 PCV に含まれる血清型の割合は16%と低かった. 患者背景は2歳未満が61%を占め, 重症例81%, 反復・遷延例45%, 保育園児72%, 鼻副鼻腔炎合併例55%と AOM 難治化の危険因子が高率に認められた. ガイドライン推奨抗菌薬が97%の症例に使用され, そのうち67%が一次治療薬で治癒していた. PCV 普及後, 小児 AOM の起炎菌はインフルエンザ菌が優勢となったが, 患者背景や治療効果に明らかな変化は認められなかった. 今後の AOM 診療は, インフルエンザ菌の検出頻度増加を念頭におきながら, 引き続き患者背景や起炎菌の薬剤感受性を考慮した治療選択を行うことが重要と考える. |
|---|---|
| AbstractList | 肺炎球菌結合型ワクチン (PCV) の世界的な普及は肺炎球菌感染症への劇的効果とともに肺炎球菌自体の変化をもたらした. 肺炎球菌は急性中耳炎 (AOM) の主な起炎菌の1つであり, その動向は AOM 診療にも影響を及ぼす. われわれは, PCV 普及後の AOM の現状を明らかにするため, 2016年7月から全国調査を実施し, 小児 AOM 患者529例 (PCV 接種率97%) を対象に起炎菌, 肺炎球菌血清型, 患者背景等について検討を行った. 検出された菌はインフルエンザ菌が57%と過半数を占め, 次いで肺炎球菌26%, 黄色ブドウ球菌8%, A 群溶血性レンサ球菌3%, モラクセラ・カタラーリス1%であった. 肺炎球菌の血清型は15A 型15%, 35B 型12%, 3型11%の順に多く, 13価 PCV に含まれる血清型の割合は16%と低かった. 患者背景は2歳未満が61%を占め, 重症例81%, 反復・遷延例45%, 保育園児72%, 鼻副鼻腔炎合併例55%と AOM 難治化の危険因子が高率に認められた. ガイドライン推奨抗菌薬が97%の症例に使用され, そのうち67%が一次治療薬で治癒していた. PCV 普及後, 小児 AOM の起炎菌はインフルエンザ菌が優勢となったが, 患者背景や治療効果に明らかな変化は認められなかった. 今後の AOM 診療は, インフルエンザ菌の検出頻度増加を念頭におきながら, 引き続き患者背景や起炎菌の薬剤感受性を考慮した治療選択を行うことが重要と考える. 肺炎球菌結合型ワクチン(PCV)の世界的な普及は肺炎球菌感染症への劇的効果とともに肺炎球菌自体の変化をもたらした. 肺炎球菌は急性中耳炎(AOM)の主な起炎菌の1つであり, その動向はAOM診療にも影響を及ぼす. われわれは, PCV普及後のAOMの現状を明らかにするため, 2016年7月から全国調査を実施し, 小児AOM患者529例(PCV接種率97%)を対象に起炎菌, 肺炎球菌血清型, 患者背景等について検討を行った. 検出された菌はインフルエンザ菌が57%と過半数を占め, 次いで肺炎球菌26%, 黄色ブドウ球菌8%, A群溶血性レンサ球菌3%, モラクセラ・カタラーリス1%であった. 肺炎球菌の血清型は15A型15%, 35B型12%, 3型11%の順に多く, 13価PCVに含まれる血清型の割合は16%と低かった. 患者背景は2歳未満が61%を占め, 重症例81%, 反復・遷延例45%, 保育園児72%, 鼻副鼻腔炎合併例55%とAOM難治化の危険因子が高率に認められた. ガイドライン推奨抗菌薬が97%の症例に使用され, そのうち67%が一次治療薬で治癒していた. PCV普及後, 小児AOMの起炎菌はインフルエンザ菌が優勢となったが, 患者背景や治療効果に明らかな変化は認められなかった. 今後のAOM診療は, インフルエンザ菌の検出頻度増加を念頭におきながら, 引き続き患者背景や起炎菌の薬剤感受性を考慮した治療選択を行うことが重要と考える. |
| Author | 生方, 公子 岩田, 敏 杢野, 恵理子 田島, 剛 諸角, 美由紀 |
| Author_xml | – sequence: 1 fullname: 田島, 剛 organization: 博慈会記念総合病院小児科 – sequence: 1 fullname: 諸角, 美由紀 organization: 慶應義塾大学医学部感染症学教室 – sequence: 1 fullname: 杢野, 恵理子 organization: 博慈会記念総合病院耳鼻咽喉科 – sequence: 1 fullname: 生方, 公子 organization: 慶應義塾大学医学部感染症学教室 – sequence: 1 fullname: 岩田, 敏 organization: 国立研究開発法人国立がん研究センター中央病院感染症部 |
| BookMark | eNo9kM1OwkAUhSdGExF5AVe-QPHOTH-mSyWCJiS6ULeTaTtoC7SmxYWugOhGDbgiwbgy_iUEYuLGlS-DBXwLi6ibc8_i5jvJt4Tm_cCXCK1gyFJTgzXPtVzXLwdlkcUEZxkz5lAKM0YVYJo6j1IAFBRdJ2QRZaLItQDAVIESSKGN3dwBpquj7iBuX8Yf18PGIH5txxc3o_rjqP78-d6f1N_Gzdaw0fvq3A8b3WHzatzpxf2n8e356OFu8tJaRgslUYlk5vem0X5-cy-3pRR3Ctu59aLiUVVjCmamaVHNFA6muuEYtilLKtUtG2PbIdJOmjQNSwNHo6qDiRQClwg2hGNpWLWBplFhxq1Kx7VFJfArri-5F5yEfrLLnTOYmihzAphxSFSAwQF0DomRJExGMSGqoSWk_IzkRTVxKPlx6FZFeMpFWHPtSoL8F8oTCjd-cgr5e7CPRMg9Qb8BHPGHmQ |
| ContentType | Journal Article |
| Copyright | 2018 一般社団法人 日本耳鼻咽喉科学会 |
| Copyright_xml | – notice: 2018 一般社団法人 日本耳鼻咽喉科学会 |
| CorporateAuthor | 慶應義塾大学医学部感染症学教室 国立研究開発法人国立がん研究センター中央病院感染症部 博慈会記念総合病院耳鼻咽喉科 博慈会記念総合病院小児科 |
| CorporateAuthor_xml | – name: 博慈会記念総合病院耳鼻咽喉科 – name: 博慈会記念総合病院小児科 – name: 慶應義塾大学医学部感染症学教室 – name: 国立研究開発法人国立がん研究センター中央病院感染症部 |
| DOI | 10.3950/jibiinkoka.121.887 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1883-0854 |
| EndPage | 898 |
| ExternalDocumentID | dz0jibik_2018_012107_006_0887_08983122475 article_jibiinkoka_121_7_121_887_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS F5P JSF KQ8 RJT |
| ID | FETCH-LOGICAL-j3458-1899b359ad1367d7c9ef436bc11cd2ec6bce97b50d534d12eaa1f217adb514c03 |
| ISSN | 0030-6622 |
| IngestDate | Thu Jul 10 16:10:47 EDT 2025 Wed Sep 03 06:30:51 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j3458-1899b359ad1367d7c9ef436bc11cd2ec6bce97b50d534d12eaa1f217adb514c03 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jibiinkoka/121/7/121_887/_article/-char/ja |
| PageCount | 12 |
| ParticipantIDs | medicalonline_journals_dz0jibik_2018_012107_006_0887_08983122475 jstage_primary_article_jibiinkoka_121_7_121_887_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20180720 |
| PublicationDateYYYYMMDD | 2018-07-20 |
| PublicationDate_xml | – month: 07 year: 2018 text: 20180720 day: 20 |
| PublicationDecade | 2010 |
| PublicationTitle | 日本耳鼻咽喉科学会会報 |
| PublicationTitleAlternate | 日耳鼻 |
| PublicationYear | 2018 |
| Publisher | 一般社団法人 日本耳鼻咽喉科学会 日本耳鼻咽喉科学会 |
| Publisher_xml | – name: 一般社団法人 日本耳鼻咽喉科学会 – name: 日本耳鼻咽喉科学会 |
| References | 24) 日本耳科学会, 日本小児耳鼻咽喉科学会, 日本耳鼻咽喉科感染症・エアロゾル学会編: 小児急性中耳炎診療ガイドライン. 金原出版; 2013. 9) Pichichero ME: Recurrent and persistent otitis media. Pediatr Infect Dis J 2000; 19: 911-916. 7) Kilpi T, Herva E, Kaijalainen T, et al: Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life. Pediatr Infect Dis J 2001; 20: 654-662. 38) Camillia R, Vescioa MF, Giufrèa M, et al: Carriage of Haemophilus influenzae is associated with pneumococcal vaccination in Italian children. Vaccine 2015; 33: 4559-4564. 22) Ubukata K, Chiba N, Hanada S, et al: Invasive Pneumococcal Diseases Surveillance Study Group: Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013. Emerg Infect Dis 2015; 21: 1956-1965. 51) Palmu AA, Herva E, Savolainen H, et al: Association of clinical signs and symptoms with bacterial findings in acute otitis media. Clin Infect Dis 2004; 38: 234-242. 6) Teele DW, Klein JO, Rosner B: Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J Infect Dis 1989; 160: 83-94. 37) O'Brien KL, Millar EV, Zell ER, et al: Effect of pneumococcal conjugate vaccine on nasopharyngeal colonization among immunized and unimmunized children in a community-randomized trial. J Infect Dis 2007; 196: 1211-1220. 42) Xu Q, Casey JR, Chang A, et al: When co-colonizing the nasopharynx Haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media. Pediatr Infect Dis J 2012; 31: 638-640. 11) Eskola J, Kilpi T, Palmu A, et al: Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med 2001; 344: 403-409. 53) 山中 昇: 小児急性中耳炎を難治化させない治療法と難治化してしまった中耳炎の治療法. 小児耳 2015; 36: 342-349. 21) Chiba N, Murayama SY, Morozumi M, et al: Rapid detection of eight causative pathogens for the diagnosis of bacterial meningitis by real-time PCR. J Infect Chemother 2009; 15: 92-98. 5) Hausdorff WP, Bryant J, Paradiso PR, et al: Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis 2000; 30: 100-121. 8) Block SL: Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. Pediatr Infect Dis J 1997; 16: 449-456. 18) Hotomi M, Billal DS, Kamide Y, et al: Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan. J Clin Microbiol 2008; 46: 3808-3810. 31) Leibovitz E, Jacobs MR, Dagan R: Haemophilus influenzae: a significant pathogen in acute otitis media. Pediatr Infect Dis J 2004; 23: 1142-1152. 2) Kilpi T, Ahman H, Jokinen J, et al: Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine in 1666 children. Clin Infect Dis 2003: 37: 1155-1164. 49) Tin Tin Htar M, Christopoulou D, Schmitt HJ: Pneumococcal serotype evolution in Western Europe. BMC Infect Dis 2015; 15: 419. 39) Dagan R, Pelton S, Bakaletz L, et al: Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease. Lancet Infect Dis 2016; 16: 480-492. 29) Ben-Shimol S, Givon-Lavi N, Leibovitz E, et al: Near-elimination of otitis media caused by 13-valent pneumococcal conjugate vaccine (PCV) serotypes in southern Israel shortly after sequential introduction of 7-valent/13-valent PCV. Clin Infect Dis 2014; 59: 1724-1732. 19) Rodgers GL, Arguedas A, Cohen R, et al: Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines. Vaccine 2009; 27: 3802-3810. 33) Casey JR, Adlowitz DG, Pichichero ME: New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2010; 29: 304-309. 45) Sugino H, Tsumura S, Kunimoto M, et al: Influence of pneumococcal conjugate vaccine on acute otitis media with severe middle ear inflammation: A retrospective multicenter study. PLoS One 2015; 10: e0137546. 56) Thornton RB, Rigby PJ, Wiertsema SP, et al: Multi-species bacterial biofilm and intracellular infection in otitis media. BMC Pediatr 2011; 11: 94. 12) Veenhoven R, Bogaert D, Uiterwaal C, et al: Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study. Lancet 2003; 361: 2189-2195. 55) Van Dyke MK, Pirçon JY, Cohen R, et al: Etiology of acute otitis media in children less than 5 years of age: A pooled analysis of 10 similarly designed observational studies. Pediatr Infect Dis J 2017; 36: 274-281. 1) Black S, Shinefield H, Fireman B, et al: Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 2000; 19: 187-195. 32) Barkai G, Leibovitz E, Givon-Lavi N, et al: Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media. Pediatr Infect Dis J 2009; 28: 466-471. 52) Leibovitz E, Serebro M, Givon-Lavi N, et al: Epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis media. Pediatr Infect Dis J 2009; 28: 381-384. 30) Kaur R, Morris M, Pichichero ME: Epidemiology of acute otitis media in the postpneumococcal conjugate vaccine era. Pediatrics 2017; 140: pii: e20170101. 27) Grijalva CG, Pelton SI: A second-generation pneumococcal conjugate vaccine for prevention of pneumococcal diseases in children. Curr Opin Pediatr 2011; 23: 98-104. 23) Kishii K, Morozumi M, Chiba N, et al: Direct detection by real-time PCR of ftsI gene mutations affecting MICs of β-lactam agents for Haemophilus influenzae isolates from meningitis. J Infect Chemother 2011; 17: 671-677. 35) 鈴木賢二, 黒野祐一, 小林俊光, 他: 第4回耳鼻咽喉科領域感染症臨床分離菌全国サーベイランス結果報告. 日耳鼻感染誌 2008; 26: 15-26. 20) 山中 昇, 保富宗城, 杉田麟也: わが国における小児急性中耳炎の疾病負担と7価肺炎球菌結合型ワクチンの医療経済効果―Prevenar は耐性肺炎球菌の抑制効果が期待できる―. 小児感染免疫 2009; 21: 37-48. 34) Ben-Shimol S, Givon-Lavi N, Leibovitz E, et al: Impact of widespread introduction of pneumococcal conjugate vaccines on pneumococcal and nonpneumococcal otitis media. Clin Infect Dis 2016; 63: 611-618. 26) Isaacman DJ, McIntosh ED, Reinert RR: Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines. Int J Infect Dis 2010; 14: e197-209. 44) Ozawa D, Yano H, Endo S, et al: Impact of the seven-valent pneumococcal conjugate vaccine on acute otitis media in Japanese children: Emergence of serotype 15A multidrug-resistant streptococcus pneumoniae in middle ear fluid isolates. Pediatr Infect Dis J 2015; 34: e217-221. 57) Takei S, Hotomi M, Yamanaka N: Minimal biofilm eradication concentration of antimicrobial agents against nontypeable Haemophilus influenzae isolated from middle ear fluids of intractable acute otitis media. J Infect Chemother 2013; 19: 504-509. 28) Pichichero ME, Casey JR: Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J 2007; 26: 12-16. 13) Pelton SI: Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge? Vaccine 2000; 19 Suppl 1: S96-99. 43) 中野貴司: 肺炎球菌予防戦略の展開～結合型ワクチンの中耳炎予防効果は? 小児耳 2011; 32: 297-304. 36) Käyhty H, Auranen K, Nohynek H, et al: Nasopharyngeal colonization: a target for pneumococcal vaccination. Expert Rev Vaccines 2006; 5: 651-667. 47) Chiba N, Morozumi M, Shouji M, et al: Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013. Emerg Infect Dis 2014; 20: 1132-1139. 17) Weil-Olivier C, van der Linden M, de Schutter I, et al: Prevention of pneumococcal diseases in the post-seven valent vaccine era: a European perspective. BMC Infect Dis 2012; 12: 207. 41) 宇野芳史: 小児急性中耳炎および小児急性鼻副鼻腔炎症例の鼻咽腔から検出された肺炎球菌の細菌学的, 分子遺伝子学的検討. 小児耳 2009; 30: 268-285. 48) 川崎 聡, 青木信樹, 田端 篤, 他: ムコイド型, 非ムコイド型肺炎球菌性市中肺炎の比較. 日化療会誌 2016; 64: 280-285. 46) 千葉菜穂子: わが国における侵襲性肺炎球菌感染症の実態とその予防としての肺炎球菌ワクチン. 日化療会誌 2011; 59: 561-572. 16) Dagan R: Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae. Clin Microbiol Infect 2009; 15 Suppl 3: 16-20. 25) Black S, France EK, Isaacman D, et al: Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2007; 26: 771-777. 50) Han SB, Kim JH, Kang JH, et al: Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media. J Infect Chemother 2017; 23: 136-141. 3) Centers for Disease Control and Prevention (CDC): Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease―United States, 1998-2003. MMWR Morb Mortal Wkly Rep 2005; 54: 893-897. 40) Syrjänen RK, Herva EE, Mäkelä PH, et al: The value of nasopharyngeal culture in predicting the etiology of acute otitis media in children less than two years of age. Pediatr Infect Dis J 2006; 25: 1032-1036. 14) Pelton SI: Acute otitis media in an era of increasing antimicrobial resistance and universal administration of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2002; 21: 599-604. 15) Poehling KA, Talbot TR, Griffin MR, et al: Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine. JAMA 2006; 295: 1668-1674. 4) Kalin M: Pneumococc |
| References_xml | – reference: 8) Block SL: Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. Pediatr Infect Dis J 1997; 16: 449-456. – reference: 13) Pelton SI: Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge? Vaccine 2000; 19 Suppl 1: S96-99. – reference: 36) Käyhty H, Auranen K, Nohynek H, et al: Nasopharyngeal colonization: a target for pneumococcal vaccination. Expert Rev Vaccines 2006; 5: 651-667. – reference: 26) Isaacman DJ, McIntosh ED, Reinert RR: Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines. Int J Infect Dis 2010; 14: e197-209. – reference: 34) Ben-Shimol S, Givon-Lavi N, Leibovitz E, et al: Impact of widespread introduction of pneumococcal conjugate vaccines on pneumococcal and nonpneumococcal otitis media. Clin Infect Dis 2016; 63: 611-618. – reference: 44) Ozawa D, Yano H, Endo S, et al: Impact of the seven-valent pneumococcal conjugate vaccine on acute otitis media in Japanese children: Emergence of serotype 15A multidrug-resistant streptococcus pneumoniae in middle ear fluid isolates. Pediatr Infect Dis J 2015; 34: e217-221. – reference: 24) 日本耳科学会, 日本小児耳鼻咽喉科学会, 日本耳鼻咽喉科感染症・エアロゾル学会編: 小児急性中耳炎診療ガイドライン. 金原出版; 2013. – reference: 50) Han SB, Kim JH, Kang JH, et al: Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media. J Infect Chemother 2017; 23: 136-141. – reference: 37) O'Brien KL, Millar EV, Zell ER, et al: Effect of pneumococcal conjugate vaccine on nasopharyngeal colonization among immunized and unimmunized children in a community-randomized trial. J Infect Dis 2007; 196: 1211-1220. – reference: 29) Ben-Shimol S, Givon-Lavi N, Leibovitz E, et al: Near-elimination of otitis media caused by 13-valent pneumococcal conjugate vaccine (PCV) serotypes in southern Israel shortly after sequential introduction of 7-valent/13-valent PCV. Clin Infect Dis 2014; 59: 1724-1732. – reference: 54) Friedel V, Zilora S, Bogaard D, et al: Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection. Epidemiol Infect 2014; 142: 2186-2194. – reference: 41) 宇野芳史: 小児急性中耳炎および小児急性鼻副鼻腔炎症例の鼻咽腔から検出された肺炎球菌の細菌学的, 分子遺伝子学的検討. 小児耳 2009; 30: 268-285. – reference: 32) Barkai G, Leibovitz E, Givon-Lavi N, et al: Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media. Pediatr Infect Dis J 2009; 28: 466-471. – reference: 22) Ubukata K, Chiba N, Hanada S, et al: Invasive Pneumococcal Diseases Surveillance Study Group: Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013. Emerg Infect Dis 2015; 21: 1956-1965. – reference: 35) 鈴木賢二, 黒野祐一, 小林俊光, 他: 第4回耳鼻咽喉科領域感染症臨床分離菌全国サーベイランス結果報告. 日耳鼻感染誌 2008; 26: 15-26. – reference: 2) Kilpi T, Ahman H, Jokinen J, et al: Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine in 1666 children. Clin Infect Dis 2003: 37: 1155-1164. – reference: 17) Weil-Olivier C, van der Linden M, de Schutter I, et al: Prevention of pneumococcal diseases in the post-seven valent vaccine era: a European perspective. BMC Infect Dis 2012; 12: 207. – reference: 31) Leibovitz E, Jacobs MR, Dagan R: Haemophilus influenzae: a significant pathogen in acute otitis media. Pediatr Infect Dis J 2004; 23: 1142-1152. – reference: 57) Takei S, Hotomi M, Yamanaka N: Minimal biofilm eradication concentration of antimicrobial agents against nontypeable Haemophilus influenzae isolated from middle ear fluids of intractable acute otitis media. J Infect Chemother 2013; 19: 504-509. – reference: 1) Black S, Shinefield H, Fireman B, et al: Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 2000; 19: 187-195. – reference: 27) Grijalva CG, Pelton SI: A second-generation pneumococcal conjugate vaccine for prevention of pneumococcal diseases in children. Curr Opin Pediatr 2011; 23: 98-104. – reference: 12) Veenhoven R, Bogaert D, Uiterwaal C, et al: Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study. Lancet 2003; 361: 2189-2195. – reference: 20) 山中 昇, 保富宗城, 杉田麟也: わが国における小児急性中耳炎の疾病負担と7価肺炎球菌結合型ワクチンの医療経済効果―Prevenar は耐性肺炎球菌の抑制効果が期待できる―. 小児感染免疫 2009; 21: 37-48. – reference: 47) Chiba N, Morozumi M, Shouji M, et al: Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013. Emerg Infect Dis 2014; 20: 1132-1139. – reference: 4) Kalin M: Pneumococcal serotypes and their clinical relevance. Thorax 1998; 53: 159-162. – reference: 51) Palmu AA, Herva E, Savolainen H, et al: Association of clinical signs and symptoms with bacterial findings in acute otitis media. Clin Infect Dis 2004; 38: 234-242. – reference: 56) Thornton RB, Rigby PJ, Wiertsema SP, et al: Multi-species bacterial biofilm and intracellular infection in otitis media. BMC Pediatr 2011; 11: 94. – reference: 45) Sugino H, Tsumura S, Kunimoto M, et al: Influence of pneumococcal conjugate vaccine on acute otitis media with severe middle ear inflammation: A retrospective multicenter study. PLoS One 2015; 10: e0137546. – reference: 7) Kilpi T, Herva E, Kaijalainen T, et al: Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life. Pediatr Infect Dis J 2001; 20: 654-662. – reference: 10) Whitney CG, Farley MM, Hadler J, et al: Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N Engl J Med 2000; 343: 1917-1924. – reference: 55) Van Dyke MK, Pirçon JY, Cohen R, et al: Etiology of acute otitis media in children less than 5 years of age: A pooled analysis of 10 similarly designed observational studies. Pediatr Infect Dis J 2017; 36: 274-281. – reference: 53) 山中 昇: 小児急性中耳炎を難治化させない治療法と難治化してしまった中耳炎の治療法. 小児耳 2015; 36: 342-349. – reference: 40) Syrjänen RK, Herva EE, Mäkelä PH, et al: The value of nasopharyngeal culture in predicting the etiology of acute otitis media in children less than two years of age. Pediatr Infect Dis J 2006; 25: 1032-1036. – reference: 6) Teele DW, Klein JO, Rosner B: Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J Infect Dis 1989; 160: 83-94. – reference: 46) 千葉菜穂子: わが国における侵襲性肺炎球菌感染症の実態とその予防としての肺炎球菌ワクチン. 日化療会誌 2011; 59: 561-572. – reference: 30) Kaur R, Morris M, Pichichero ME: Epidemiology of acute otitis media in the postpneumococcal conjugate vaccine era. Pediatrics 2017; 140: pii: e20170101. – reference: 9) Pichichero ME: Recurrent and persistent otitis media. Pediatr Infect Dis J 2000; 19: 911-916. – reference: 52) Leibovitz E, Serebro M, Givon-Lavi N, et al: Epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis media. Pediatr Infect Dis J 2009; 28: 381-384. – reference: 3) Centers for Disease Control and Prevention (CDC): Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease―United States, 1998-2003. MMWR Morb Mortal Wkly Rep 2005; 54: 893-897. – reference: 48) 川崎 聡, 青木信樹, 田端 篤, 他: ムコイド型, 非ムコイド型肺炎球菌性市中肺炎の比較. 日化療会誌 2016; 64: 280-285. – reference: 16) Dagan R: Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae. Clin Microbiol Infect 2009; 15 Suppl 3: 16-20. – reference: 38) Camillia R, Vescioa MF, Giufrèa M, et al: Carriage of Haemophilus influenzae is associated with pneumococcal vaccination in Italian children. Vaccine 2015; 33: 4559-4564. – reference: 5) Hausdorff WP, Bryant J, Paradiso PR, et al: Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis 2000; 30: 100-121. – reference: 14) Pelton SI: Acute otitis media in an era of increasing antimicrobial resistance and universal administration of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2002; 21: 599-604. – reference: 21) Chiba N, Murayama SY, Morozumi M, et al: Rapid detection of eight causative pathogens for the diagnosis of bacterial meningitis by real-time PCR. J Infect Chemother 2009; 15: 92-98. – reference: 43) 中野貴司: 肺炎球菌予防戦略の展開～結合型ワクチンの中耳炎予防効果は? 小児耳 2011; 32: 297-304. – reference: 18) Hotomi M, Billal DS, Kamide Y, et al: Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan. J Clin Microbiol 2008; 46: 3808-3810. – reference: 23) Kishii K, Morozumi M, Chiba N, et al: Direct detection by real-time PCR of ftsI gene mutations affecting MICs of β-lactam agents for Haemophilus influenzae isolates from meningitis. J Infect Chemother 2011; 17: 671-677. – reference: 15) Poehling KA, Talbot TR, Griffin MR, et al: Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine. JAMA 2006; 295: 1668-1674. – reference: 25) Black S, France EK, Isaacman D, et al: Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2007; 26: 771-777. – reference: 49) Tin Tin Htar M, Christopoulou D, Schmitt HJ: Pneumococcal serotype evolution in Western Europe. BMC Infect Dis 2015; 15: 419. – reference: 28) Pichichero ME, Casey JR: Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J 2007; 26: 12-16. – reference: 19) Rodgers GL, Arguedas A, Cohen R, et al: Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines. Vaccine 2009; 27: 3802-3810. – reference: 42) Xu Q, Casey JR, Chang A, et al: When co-colonizing the nasopharynx Haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media. Pediatr Infect Dis J 2012; 31: 638-640. – reference: 39) Dagan R, Pelton S, Bakaletz L, et al: Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease. Lancet Infect Dis 2016; 16: 480-492. – reference: 11) Eskola J, Kilpi T, Palmu A, et al: Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med 2001; 344: 403-409. – reference: 33) Casey JR, Adlowitz DG, Pichichero ME: New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2010; 29: 304-309. |
| SSID | ssib000940320 ssib007762623 ssib002484658 ssj0066768 ssib000959836 ssib002252301 ssib001174089 ssib022575415 ssib058493820 ssib005879730 ssib001174090 |
| Score | 2.1530132 |
| Snippet | 肺炎球菌結合型ワクチン (PCV) の世界的な普及は肺炎球菌感染症への劇的効果とともに肺炎球菌自体の変化をもたらした. 肺炎球菌は急性中耳炎 (AOM) の主な起炎菌の1つであり, その動向は AOM 診療にも影響を及ぼす. われわれは, PCV 普及後の AOM の現状を明らかにするため,... 肺炎球菌結合型ワクチン(PCV)の世界的な普及は肺炎球菌感染症への劇的効果とともに肺炎球菌自体の変化をもたらした. 肺炎球菌は急性中耳炎(AOM)の主な起炎菌の1つであり, その動向はAOM診療にも影響を及ぼす. われわれは, PCV普及後のAOMの現状を明らかにするため, 2016年7月から全国調査を実施し,... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 887 |
| SubjectTerms | インフルエンザ菌 急性中耳炎 肺炎球菌 肺炎球菌結合型ワクチン |
| Title | PCV13 普及後の小児急性中耳炎に関する疫学的検討 |
| URI | https://www.jstage.jst.go.jp/article/jibiinkoka/121/7/121_887/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=dz0jibik/2018/012107/006&name=0887-0898j |
| Volume | 121 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本耳鼻咽喉科学会会報, 2018/07/20, Vol.121(7), pp.887-898 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR3LbtQwMGqLhJAQ4inKSz3g4xYnsWPPCZJtqgpUBFKLeouSza7UrWgRtJee2gougFpOlYo4IV5S1QqJCyf-gW9Ydlv-ghkn3fVSDrwu1sQez4zHjj2T2GPHuRqk6MhqKSq5lHQkJ4WKToFXeD2ta577gUzp7PDk7WBiWtyckTMDg1-tXUtLi9lobfmX50r-plcxD_uVTsn-Qc92iWIGwti_mGIPY_pbfXynes_1WRwwABbGLJZMjzMdEhDFTFdZ7KOlWBZFnEoJRzLgVEtzFsoDQLFYsEizcIzFmnIipKyY9piOD-hELAYGAQu9Mgf5EoA4ESFTUUQskEgYmJyQaUEsQsGgSpRDJB7bJrGRX5WSIE5YtQQAFlVZZGiCx6IxA6DAQMRRZnAtdoKQkWMPwCKk0x1VhsOYER-YVqZlAbUjkkZY1FBQ0gPeq6SpVagaAhTJgbik39hUQmauyUGr3KpkSmDcsAxYBKXmqXWHGBRUuOkln0VGBmwiRPY3GVfTx16Pd9-i_644ewXz0d0PvP4VrDhkXr6qylqPdGnNlKZNceH3z6umD5K2mTZns9nZ-bmFuZRCjox2q_ZFI8-XOeHNJdTshAICctrAECS0WmEC2qd_tUoOOkc8pczOiVt3LYsfBPdtDwUkVrEjGCrBrQsQzHPfUW36jWFFlNMKlOUBK1zcLYse0ZW0vhiguQ2-iRBZGGu0w7sw1kq1FufqSCPXDusDrdQm-mwUjOP4_eI_ahHPxjJJp046J0pfciQsJoZTzkAzPe0cnSx3y5xxQjM_dLZ22xtP21-et1Z32x832k9edFbedlbef_u8s7_yaW9tvbW6_X3zdWt1q7X2bG9zu73zbu_l486bV_sf1s860-PxVHWiUl6ZUmn6QuqKqwEyX0KaUyjGXNWg3hB-kNVct5Z79RpCdVCZ5Ln0Re569TR1G56r0jxDz6nG_XPO0PzCfP28M5J5IFSjkabo0wkQAh3bQNFtGi6iBloOO9cLZSQPirg4STkPJj3FJai4RJmUhscBAh0oTZrpsHOjT4tJObU-Sn57lF34dxIXnWO9V_iSM7T4cKl-GR2NxeyKGbo_AIBe44c |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=PCV13%E6%99%AE%E5%8F%8A%E5%BE%8C%E3%81%AE%E5%B0%8F%E5%85%90%E6%80%A5%E6%80%A7%E4%B8%AD%E8%80%B3%E7%82%8E%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E7%96%AB%E5%AD%A6%E7%9A%84%E6%A4%9C%E8%A8%8E&rft.jtitle=%E6%97%A5%E6%9C%AC%E8%80%B3%E9%BC%BB%E5%92%BD%E5%96%89%E7%A7%91%E5%AD%A6%E4%BC%9A%E4%BC%9A%E5%A0%B1&rft.au=%E6%9D%A2%E9%87%8E%E6%81%B5%E7%90%86%E5%AD%90&rft.au=%E8%AB%B8%E8%A7%92%E7%BE%8E%E7%94%B1%E7%B4%80&rft.au=%E7%94%9F%E6%96%B9%E5%85%AC%E5%AD%90&rft.au=%E7%94%B0%E5%B3%B6%E5%89%9B&rft.date=2018-07-20&rft.pub=%E6%97%A5%E6%9C%AC%E8%80%B3%E9%BC%BB%E5%92%BD%E5%96%89%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=0030-6622&rft.volume=121&rft.issue=7&rft.spage=887&rft.epage=898&rft_id=info:doi/10.3950%2Fjibiinkoka.121.887&rft.externalDocID=dz0jibik_2018_012107_006_0887_08983122475 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0030-6622&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0030-6622&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0030-6622&client=summon |