Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes

• Published in: Experimental dermatology Vol. 28; no. 7; pp. 786 - 794
• Main Authors: Lu, Jin, Cong, Tianxin, Wen, Xiang, Li, Xiaoxue, Du, Dan, He, Gu, Jiang, Xian
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.07.2019
• Subjects: Acids; Acne; acne vulgaris; Adenosine kinase; AMP; Apoptosis; Cell viability; Cytokines; Inflammation; Keratinization; Keratinocytes; Kinases; Lipids; Lipogenesis; NF‐κB; Protein kinase; Salicylic acid; sebocyte; Skin; SREBP‐1; Sterol regulatory element-binding protein; NF-κB; acne vulgaris; salicylic acid; sebocyte; inflammation; SREBP-1

Acne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over‐keratinization of follicular keratinocytes and Propionibacterium acnes (P acnes) overgrowth. Salicylic acid (SA), a beta‐hydroxy acid, is frequently used i...