Identification of DOCK4 and its splicing variant as PIP3 binding proteins

• Published in: IUBMB life Vol. 60; no. 7; p. 467
• Main Authors: Kanai, Akinori, Ihara, Sayoko, Ohdaira, Tsutomu, Shinohara-Kanda, Azusa, Iwamatsu, Akihiro, Fukui, Yasuhisa
• Format: Journal Article
• Language: English
• Published: England 01.07.2008
• Subjects: Alternative Splicing; Carrier Proteins; Cell Line; Cloning, Molecular; Exons; Gene Expression Regulation; GTPase-Activating Proteins - chemistry; Humans; Microscopy, Confocal; Models, Biological; Mutation; Protein Binding; Protein Isoforms; rac GTP-Binding Proteins - chemistry; Transfection

DOCK4, a member of DOCK180 family proteins, was originally identified as a product of a gene deleted during tumor progression. Although its tumor suppression properties have been reported, the regulation mechanism of this protein has not been fully elucidated. DOCK4 shares two conserved domains call...