DAMAGE AND REPAIR OF DNA IN URINARY BLADDER EPITHELIUM OF RATS TREATED WITH N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE

• Published in: GANN Japanese Journal of Cancer Research Vol. 68; no. 6; pp. 781 - 783
• Main Authors: TSUDA, Hiroyuki, MIYATA, Yukitada, HAGIWARA, Akihiro, HASEGAWA, Ryohei, SHIRAI, Tomoyuki, ITO, Nobuyuki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Cancer Association 01.01.1977
• Subjects: Animals; Butylhydroxybutylnitrosamine - administration & dosage; Butylhydroxybutylnitrosamine - toxicity; DNA - analysis; DNA damage and repair; DNA Repair; Epithelium - metabolism; Male; N-Butyl-N-(4-hydroxybutyl) nitrosamine; Neoplasms, Experimental - chemically induced; Nitrosamines - toxicity; Rats; Urinary Bladder - drug effects; Urinary Bladder - metabolism; Urinary bladder epithelium; Urinary Bladder Neoplasms - chemically induced; Wistar rat

N-Butyl-N-(4-hydroxybutyl) nitrosamine (BBN), which selectively induced urinary bladder tumors in several experimental animal species, was found to cause damage of DNA in the bladder epithelium. Wistar strain rats were given 100mg/kg of BBN intravesically and killed after 2, 6, 12, 24, or 48hr. DNA...