脳磁図の臨床応用に関する文献レビュー (第6報) : 神経変性・脱髄疾患と神経リハビリテーション
脳磁図の科学的エビデンスは, てんかん以外の疾患において明らかでない。本研究では文献検索に基づき神経内科疾患と神経リハビリテーションの脳磁図臨床研究の動向を調べることを目的とした。MEDLINE にて (amyotrophic lateral sclerosisなど個々の対象疾患名) AND (MEG OR magnetoencephalography) を検索して2011年11月までに発表された論文を抽出した。この中から原著論文をえらび, エビデンスレベル, 抄録内容に基づいて, 神経内科疾患ではALS 3編, Parkinson病8編, 多発性硬化症4編について概要をまとめた。神経リハビリ...
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Published in | 臨床神経生理学 Vol. 41; no. 2; pp. 57 - 70 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | Japanese |
Published |
一般社団法人 日本臨床神経生理学会
2013
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Online Access | Get full text |
ISSN | 1345-7101 2188-031X |
DOI | 10.11422/jscn.41.57 |
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Abstract | 脳磁図の科学的エビデンスは, てんかん以外の疾患において明らかでない。本研究では文献検索に基づき神経内科疾患と神経リハビリテーションの脳磁図臨床研究の動向を調べることを目的とした。MEDLINE にて (amyotrophic lateral sclerosisなど個々の対象疾患名) AND (MEG OR magnetoencephalography) を検索して2011年11月までに発表された論文を抽出した。この中から原著論文をえらび, エビデンスレベル, 抄録内容に基づいて, 神経内科疾患ではALS 3編, Parkinson病8編, 多発性硬化症4編について概要をまとめた。神経リハビリテーションについては虚血性脳血管障害からの回復に関わる研究に焦点を絞り, 運動感覚障害9編, 失語症3編について概要をまとめた。27編のうち診断・治療方針の決定に関するエビデンスレベルはグレード1: 0編, 2: 18編, 3: 3編, 4: 6編, 5: 0編, 6: 0編であった。脳磁図は局所の自発活動を非侵襲的に計測できることから, 少数症例の検討ながら, 複数の領域間の機能的連絡あるいは視床下核などの深部組織の活動と脳局所のコヒーレンスなど, 疾患や回復過程に伴う脳機能変化や疾患固有の病態生理を理解する上で新しい知見をもたらすことがわかった。 |
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AbstractList | 脳磁図の科学的エビデンスは, てんかん以外の疾患において明らかでない。本研究では文献検索に基づき神経内科疾患と神経リハビリテーションの脳磁図臨床研究の動向を調べることを目的とした。MEDLINE にて (amyotrophic lateral sclerosisなど個々の対象疾患名) AND (MEG OR magnetoencephalography) を検索して2011年11月までに発表された論文を抽出した。この中から原著論文をえらび, エビデンスレベル, 抄録内容に基づいて, 神経内科疾患ではALS 3編, Parkinson病8編, 多発性硬化症4編について概要をまとめた。神経リハビリテーションについては虚血性脳血管障害からの回復に関わる研究に焦点を絞り, 運動感覚障害9編, 失語症3編について概要をまとめた。27編のうち診断・治療方針の決定に関するエビデンスレベルはグレード1: 0編, 2: 18編, 3: 3編, 4: 6編, 5: 0編, 6: 0編であった。脳磁図は局所の自発活動を非侵襲的に計測できることから, 少数症例の検討ながら, 複数の領域間の機能的連絡あるいは視床下核などの深部組織の活動と脳局所のコヒーレンスなど, 疾患や回復過程に伴う脳機能変化や疾患固有の病態生理を理解する上で新しい知見をもたらすことがわかった。 |
Author | 亀山, 茂樹 鎌田, 恭輔 平田, 雅之 露口, 尚弘 石井, 良平 尾﨑, 勇 渡辺, 裕貴 井口, 義信 橋本, 勲 白石, 秀明 |
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References | 29) Tecchio F, Zappasodi F, Tombini M, et al: Brain plasticity in recovery from stroke: an MEG assessment. Neuroimage 32: 1326–1334, 2006. 3) 平田雅之, 亀山茂樹, 後藤 哲ら: 脳磁図の臨床応用に関する文献レビュー (第1報): てんかん. 臨床神経生理学 40: 140–146, 2012. 38) Breier JI, Juranek J, Maher LM, et al: Behavioral and neurophysiologic response to therapy for chronic aphasia. Arch Phys Med Rehabil 90: 2026–2033, 2009. 5) 白石秀明, 尾﨑 勇, 井口義信ら: 脳磁図の臨床応用に関する文献レビュー (第3報): 小児疾患. 臨床神経生理学 40: 203–208, 2012. 40) Meinzer M, Paul I, Wienbruch C, et al: Electromagnetic brain activity in higher frequency bands during automatic word processing indicates recovery of function in aphasia. Eur J Phys Rehabil Med 45: 369–378, 2009. 27) Roiha K, Kirveskari E, Kaste M, et al: Reorganization of the primary somatosensory cortex during stroke recovery. Clin Neurophysiol 122: 339–345, 2011. 30) Huang M, Davis LE, Aine C, et al: MEG response to median nerve stimulation correlates with recovery of sensory and motor function after stroke. Clin Neurophysiol 115: 820–833, 2004. 2) Mogilner A, Grossman JA, Ribary U, et al: Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proc Natl Acad Sci USA 90(8): 3593–3597, 1993. 24) Hagiwara K, Okamoto T, Shigeto H, et al: Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans. Neuroimage 15; 51(1): 412–420, 2010. 18) Kühn AA, Kempf F, Brucke C, et al: High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson’s disease in parallel with improvement in motor performance. J Neurosci 28: 6165–6173, 2008. 36) Zappasodi F, Tombini M, Milazzo D, et al: Delta dipole density and strength in acute monohemispheric stroke. Neurosci Lett 416: 310–314, 2007. 26) Rossini PM, Tecchio F, Pizzella V, et al: Interhemispheric differences of sensory hand areas after monohemispheric stroke: MEG/MRI integrative study. Neuroimage 14: 474–485, 2001. 39) Meinzer M, Elbert T, Wienbruch C, et al: Intensive language training enhances brain plasticity in chronic aphasia. BMC Biol 2: 20, 2004. doi:10.1186/1741-7007-2-20 12) Boesveldt S, Stam CJ, Knol DL, et al: Advanced time-series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson’s disease patients. Hum Brain Mapp 30(9): 3020–3030, 2009. 1) Nunez PL: Electric Field of the Brain. The Neurophysics of EEG. Oxford University Press, Oxford, 1981. 14) Vardy AN, van Wegen EE, Kwakkel G, et al: Slowing of M1 activity in Parkinson’s disease during rest and movement—an MEG study. Clin Neurophysiol 122(4): 789–795, 2011. 22) Tecchio F, Zito G, Zappasodi F, et al: Intra-cortical connectivity in multiple sclerosis: a neurophysiological approach. Brain 131(Pt 7): 1783–1792, 2008. 8) Pekkonen E, Osipova D, Laaksovirta H: Magnetoencephalographic evidence of abnormal auditory processing in amyotrophic lateral sclerosis with bulbar signs. Clin Neurophysiol 115(2): 309–315, 2004. 23) Dell’Acqua ML, Landi D, Zito G, et al: Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment. Hum Brain Mapp 31(10): 1588–1600, 2010. 10) Teismann IK, Warnecke T, Suntrup S, et al: Cortical processing of swallowing in ALS patients with progressive dysphagia—a magnetoencephalographic study. PLoS One 6(5): e19987, 2011. doi: 10.1371/journal.pone.0019987 35) Tecchio F, Pasqualetti P, Zappasodi F, et al: Outcome prediction in acute monohemispheric stroke via magnetoencephalography. J Neurol 254: 296–305, 2007. 19) Litvak V, Jha A, Eusebio A, et al: Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson’s disease. Brain 134(Pt 2): 359–374, 2011. 13) Gómez C, Olde Dubbelink KT, Stam CJ, et al: Complexity analysis of resting-state MEG activity in early-stage Parkinson’s disease patients. Ann Biomed Eng 39(12): 2935–2944, 2011. 25) Schoonheim MM, Geurts JJ, Landi D, et al: Functional connectivity changes in multiple sclerosis patients: A graph analytical study of MEG resting state data. Hum Brain Mapp 4(1): 52–61, 2011. 20) Hirschmann J, Özkurt TE, Butz M, et al: Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson’s disease. Neuroimage 55(3): 1159–1168, 2011. 9) Boyajian RA, Amo C, Otis SM, et al: Magnetic source imaging of cortical dysfunction in amyotrophic lateral sclerosis. Am J Phys Med Rehabil 87(6): 427–437, 2008. 28) Gallien P, Aghulon C, Durufle A, et al: Magnetoencephalography in stroke: a 1-year follow-up study. Eur J Neurol 10: 373–382, 2003. 16) Pollok B, Makhloufi H, Butz M, et al: Levodopa affects functional brain networks in Parkinsonian resting tremor. Mov Disord 24(1): 91–98, 2009. 21) Wichmann T, DeLong MR: Ch 43. The basal ganglia. In Kandel E, Schwartz J, Jessell T, et al (eds). Principles of Neural Science (5th ed). McGraw-Hill Companies, New York, pp 982–998, 2012. 31) Altamura C, Torquati K, Zappasodi F, et al: fMRI-vs-MEG evaluation of post-stroke interhemispheric asymmetries in primary sensorimotor hand areas. Exp Neurol 204: 631–639, 2007. 6) 石井良平, 渡辺裕貴, 青木保典ら: 脳磁図の臨床応用に関する文献レビュー (第4報): 精神科疾患・認知症. 臨床神経生理学 41: 29–45, 2013. 17) Helmich RC, Hallett M, Deuschl G, et al: Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain 135(Pt 11): 3206–3226, 2012. 32) Rizzolatti G, Kalaska JF: Ch 38. Voluntary movement: The parietal and premotor cortex. In Kandel E, Schwartz J, Jessell T, et al (eds). Principles of Neural Science (5th ed). McGraw-Hill Companies, New York, pp 865–893, 2012. 33) Lisberger SG, Thach WT: Ch 42. The cerebellum. In Kandel E, Schwartz J, Jessell T, et al (eds). Principles of Neural Science (5th ed). McGraw-Hill Companies, New York, pp 960–981, 2012. 4) 露口尚弘, 鎌田恭輔, 中里信和ら: 脳磁図の臨床応用に関する文献レビュー (第2報): 虚血性脳血管障害. 臨床神経生理学 40: 195–202, 2012. 15) Airaksinen K, Mäkelä JP, Taulu S, et al: Effects of DBS on auditory and somatosensory processing in Parkinson’s disease. Hum Brain Mapp 32(7): 1091–1099, 2011. 7) 鎌田恭輔, 露口尚弘, 中里信和ら: 脳磁図の臨床応用に関する文献レビュー (第5報): 脳腫瘍. 臨床神経生理学 41: 46–53, 2013. 37) Butz M, Gross J, Timmermann L, et al: Perilesional pathological oscillatory activity in the magnetoencephalogram of patients with cortical brain lesions. Neurosci Lett 355: 93–96, 2004. 11) Stoffers D, Bosboom JL, Deijen JB, et al: Slowing of oscillatory brain activity is a stable characteristic of Parkinson’s disease without dementia. Brain 130(Pt 7): 1847–1860, 2007. 34) Small SL, Hlustik P, Noll DC, et al: Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke. Brain 125(Pt 7): 1544–1557, 2002. |
References_xml | – reference: 33) Lisberger SG, Thach WT: Ch 42. The cerebellum. In Kandel E, Schwartz J, Jessell T, et al (eds). Principles of Neural Science (5th ed). McGraw-Hill Companies, New York, pp 960–981, 2012. – reference: 1) Nunez PL: Electric Field of the Brain. The Neurophysics of EEG. Oxford University Press, Oxford, 1981. – reference: 40) Meinzer M, Paul I, Wienbruch C, et al: Electromagnetic brain activity in higher frequency bands during automatic word processing indicates recovery of function in aphasia. Eur J Phys Rehabil Med 45: 369–378, 2009. – reference: 4) 露口尚弘, 鎌田恭輔, 中里信和ら: 脳磁図の臨床応用に関する文献レビュー (第2報): 虚血性脳血管障害. 臨床神経生理学 40: 195–202, 2012. – reference: 37) Butz M, Gross J, Timmermann L, et al: Perilesional pathological oscillatory activity in the magnetoencephalogram of patients with cortical brain lesions. Neurosci Lett 355: 93–96, 2004. – reference: 32) Rizzolatti G, Kalaska JF: Ch 38. Voluntary movement: The parietal and premotor cortex. In Kandel E, Schwartz J, Jessell T, et al (eds). Principles of Neural Science (5th ed). McGraw-Hill Companies, New York, pp 865–893, 2012. – reference: 35) Tecchio F, Pasqualetti P, Zappasodi F, et al: Outcome prediction in acute monohemispheric stroke via magnetoencephalography. J Neurol 254: 296–305, 2007. – reference: 20) Hirschmann J, Özkurt TE, Butz M, et al: Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson’s disease. Neuroimage 55(3): 1159–1168, 2011. – reference: 23) Dell’Acqua ML, Landi D, Zito G, et al: Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment. Hum Brain Mapp 31(10): 1588–1600, 2010. – reference: 3) 平田雅之, 亀山茂樹, 後藤 哲ら: 脳磁図の臨床応用に関する文献レビュー (第1報): てんかん. 臨床神経生理学 40: 140–146, 2012. – reference: 39) Meinzer M, Elbert T, Wienbruch C, et al: Intensive language training enhances brain plasticity in chronic aphasia. BMC Biol 2: 20, 2004. doi:10.1186/1741-7007-2-20 – reference: 29) Tecchio F, Zappasodi F, Tombini M, et al: Brain plasticity in recovery from stroke: an MEG assessment. Neuroimage 32: 1326–1334, 2006. – reference: 38) Breier JI, Juranek J, Maher LM, et al: Behavioral and neurophysiologic response to therapy for chronic aphasia. Arch Phys Med Rehabil 90: 2026–2033, 2009. – reference: 10) Teismann IK, Warnecke T, Suntrup S, et al: Cortical processing of swallowing in ALS patients with progressive dysphagia—a magnetoencephalographic study. PLoS One 6(5): e19987, 2011. doi: 10.1371/journal.pone.0019987 – reference: 2) Mogilner A, Grossman JA, Ribary U, et al: Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proc Natl Acad Sci USA 90(8): 3593–3597, 1993. – reference: 19) Litvak V, Jha A, Eusebio A, et al: Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson’s disease. Brain 134(Pt 2): 359–374, 2011. – reference: 16) Pollok B, Makhloufi H, Butz M, et al: Levodopa affects functional brain networks in Parkinsonian resting tremor. Mov Disord 24(1): 91–98, 2009. – reference: 14) Vardy AN, van Wegen EE, Kwakkel G, et al: Slowing of M1 activity in Parkinson’s disease during rest and movement—an MEG study. Clin Neurophysiol 122(4): 789–795, 2011. – reference: 36) Zappasodi F, Tombini M, Milazzo D, et al: Delta dipole density and strength in acute monohemispheric stroke. Neurosci Lett 416: 310–314, 2007. – reference: 11) Stoffers D, Bosboom JL, Deijen JB, et al: Slowing of oscillatory brain activity is a stable characteristic of Parkinson’s disease without dementia. Brain 130(Pt 7): 1847–1860, 2007. – reference: 18) Kühn AA, Kempf F, Brucke C, et al: High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson’s disease in parallel with improvement in motor performance. J Neurosci 28: 6165–6173, 2008. – reference: 27) Roiha K, Kirveskari E, Kaste M, et al: Reorganization of the primary somatosensory cortex during stroke recovery. Clin Neurophysiol 122: 339–345, 2011. – reference: 17) Helmich RC, Hallett M, Deuschl G, et al: Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain 135(Pt 11): 3206–3226, 2012. – reference: 24) Hagiwara K, Okamoto T, Shigeto H, et al: Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans. Neuroimage 15; 51(1): 412–420, 2010. – reference: 25) Schoonheim MM, Geurts JJ, Landi D, et al: Functional connectivity changes in multiple sclerosis patients: A graph analytical study of MEG resting state data. Hum Brain Mapp 4(1): 52–61, 2011. – reference: 9) Boyajian RA, Amo C, Otis SM, et al: Magnetic source imaging of cortical dysfunction in amyotrophic lateral sclerosis. Am J Phys Med Rehabil 87(6): 427–437, 2008. – reference: 30) Huang M, Davis LE, Aine C, et al: MEG response to median nerve stimulation correlates with recovery of sensory and motor function after stroke. Clin Neurophysiol 115: 820–833, 2004. – reference: 8) Pekkonen E, Osipova D, Laaksovirta H: Magnetoencephalographic evidence of abnormal auditory processing in amyotrophic lateral sclerosis with bulbar signs. Clin Neurophysiol 115(2): 309–315, 2004. – reference: 31) Altamura C, Torquati K, Zappasodi F, et al: fMRI-vs-MEG evaluation of post-stroke interhemispheric asymmetries in primary sensorimotor hand areas. Exp Neurol 204: 631–639, 2007. – reference: 22) Tecchio F, Zito G, Zappasodi F, et al: Intra-cortical connectivity in multiple sclerosis: a neurophysiological approach. Brain 131(Pt 7): 1783–1792, 2008. – reference: 13) Gómez C, Olde Dubbelink KT, Stam CJ, et al: Complexity analysis of resting-state MEG activity in early-stage Parkinson’s disease patients. Ann Biomed Eng 39(12): 2935–2944, 2011. – reference: 26) Rossini PM, Tecchio F, Pizzella V, et al: Interhemispheric differences of sensory hand areas after monohemispheric stroke: MEG/MRI integrative study. Neuroimage 14: 474–485, 2001. – reference: 6) 石井良平, 渡辺裕貴, 青木保典ら: 脳磁図の臨床応用に関する文献レビュー (第4報): 精神科疾患・認知症. 臨床神経生理学 41: 29–45, 2013. – reference: 5) 白石秀明, 尾﨑 勇, 井口義信ら: 脳磁図の臨床応用に関する文献レビュー (第3報): 小児疾患. 臨床神経生理学 40: 203–208, 2012. – reference: 12) Boesveldt S, Stam CJ, Knol DL, et al: Advanced time-series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson’s disease patients. Hum Brain Mapp 30(9): 3020–3030, 2009. – reference: 15) Airaksinen K, Mäkelä JP, Taulu S, et al: Effects of DBS on auditory and somatosensory processing in Parkinson’s disease. Hum Brain Mapp 32(7): 1091–1099, 2011. – reference: 34) Small SL, Hlustik P, Noll DC, et al: Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke. Brain 125(Pt 7): 1544–1557, 2002. – reference: 21) Wichmann T, DeLong MR: Ch 43. The basal ganglia. In Kandel E, Schwartz J, Jessell T, et al (eds). Principles of Neural Science (5th ed). McGraw-Hill Companies, New York, pp 982–998, 2012. – reference: 7) 鎌田恭輔, 露口尚弘, 中里信和ら: 脳磁図の臨床応用に関する文献レビュー (第5報): 脳腫瘍. 臨床神経生理学 41: 46–53, 2013. – reference: 28) Gallien P, Aghulon C, Durufle A, et al: Magnetoencephalography in stroke: a 1-year follow-up study. Eur J Neurol 10: 373–382, 2003. |
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Snippet | 脳磁図の科学的エビデンスは, てんかん以外の疾患において明らかでない。本研究では文献検索に基づき神経内科疾患と神経リハビリテーションの脳磁図臨床研究の動向を調べることを目的とした。MEDLINE にて (amyotrophic lateral sclerosisなど個々の対象疾患名) AND (MEG OR... |
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StartPage | 57 |
Title | 脳磁図の臨床応用に関する文献レビュー (第6報) : 神経変性・脱髄疾患と神経リハビリテーション |
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Volume | 41 |
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ispartofPNX | 臨床神経生理学, 2013/04/01, Vol.41(2), pp.57-70 |
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