Regulation of the intrinsic apoptosis pathway by reactive oxygen species

• Published in: Antioxidants & redox signaling Vol. 19; no. 6; p. 546
• Main Authors: Wu, Chu-Chiao, Bratton, Shawn B
• Format: Journal Article
• Language: English
• Published: United States 20.08.2013
• Subjects: Animals; Apoptosis; Caspase 9 - metabolism; Cytochromes c - metabolism; Humans; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial Membranes; Oxidative Stress; Permeability; Proto-Oncogene Proteins c-bcl-2 - metabolism; Reactive Oxygen Species - metabolism

The intrinsic apoptosis pathway is conserved from worms to humans and plays a critical role in the normal development and homeostatic control of adult tissues. As a result, numerous diseases from cancer to neurodegeneration are associated with either too little or too much apoptosis. B cell lymphoma...