潰瘍性大腸炎に限局性筋膜炎を合併した1例

症例は36歳男性.4年前に潰瘍性大腸炎と診断.2020年10月に血便を来し,潰瘍性大腸炎再燃との診断で,サラゾスルファピリジン内服開始15日後に右下腿痛と腫脹が出現した.MRIで右下腿の筋膜や血管周囲にT2脂肪抑制画像で高信号,造影T1脂肪抑制画像で増強効果を認めた.右下腿の腫脹は自然軽快するも,左下腿にも腫脹,疼痛が出現した.MRIでは右と同所見で,筋生検では筋組織に異常所見は認めず,臨床経過から限局性筋膜炎と診断した.Crohn病に合併して限局性筋膜炎を来すgastrocnemius myalgia syndromeの報告が多いが,潰瘍性大腸炎では稀である.状況に応じて安静及びステロイドな...

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Published in臨床神経学 Vol. 62; no. 7; pp. 546 - 551
Main Authors 菊池, 真介, 平野, 晋資, 谷脇, 考恭, 立石, 貴久, 入江, 研一, 上野, 俊太郎
Format Journal Article
LanguageJapanese
Published 日本神経学会 2022
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ISSN0009-918X
1882-0654
DOI10.5692/clinicalneurol.cn-001716

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Abstract 症例は36歳男性.4年前に潰瘍性大腸炎と診断.2020年10月に血便を来し,潰瘍性大腸炎再燃との診断で,サラゾスルファピリジン内服開始15日後に右下腿痛と腫脹が出現した.MRIで右下腿の筋膜や血管周囲にT2脂肪抑制画像で高信号,造影T1脂肪抑制画像で増強効果を認めた.右下腿の腫脹は自然軽快するも,左下腿にも腫脹,疼痛が出現した.MRIでは右と同所見で,筋生検では筋組織に異常所見は認めず,臨床経過から限局性筋膜炎と診断した.Crohn病に合併して限局性筋膜炎を来すgastrocnemius myalgia syndromeの報告が多いが,潰瘍性大腸炎では稀である.状況に応じて安静及びステロイドなどの治療が重要である.
AbstractList 症例は36歳男性.4年前に潰瘍性大腸炎と診断.2020年10月に血便を来し,潰瘍性大腸炎再燃との診断で,サラゾスルファピリジン内服開始15日後に右下腿痛と腫脹が出現した.MRIで右下腿の筋膜や血管周囲にT2脂肪抑制画像で高信号,造影T1脂肪抑制画像で増強効果を認めた.右下腿の腫脹は自然軽快するも,左下腿にも腫脹,疼痛が出現した.MRIでは右と同所見で,筋生検では筋組織に異常所見は認めず,臨床経過から限局性筋膜炎と診断した.Crohn病に合併して限局性筋膜炎を来すgastrocnemius myalgia syndromeの報告が多いが,潰瘍性大腸炎では稀である.状況に応じて安静及びステロイドなどの治療が重要である.
Author 上野, 俊太郎
立石, 貴久
平野, 晋資
菊池, 真介
入江, 研一
谷脇, 考恭
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References 1) Lakatos PL, Lakatos L, Kiss LS, et al. Treatment of extraintestinal manifestations in inflammatory bowel disease. Digestion 2012;86:28-35.
3) 山本真義,井上学,立花直子ら.潰瘍性大腸炎に合併しgastrocnemius myalgia syndrome様の症状を呈した非肉芽腫性筋炎の1例.臨床神経 2017;57:71-76.
9) Shimoyama T, Tamura Y, Sakamoto T, et al. Immune-mediated myositis in Crohn’s disease. Muscle Nerve 2009;39:101-105.
17) Dioszeghy P, Molnar M, Mechler F. Muscle involvement in Crohn disease. Orv Hetil 1994;135:1259-1261.
6) Qureshi JA, Staugaitis SM, Calabrese LH, et al. Neurtophilic myositis: an extra-intestinal manifestation of ulcerative colitis. J ‍Clin Rheumatol 2002;8:85-88.
13) Chazerain P, Vigneron AM, Grossin M, et al. Posttraumatic diffuse eosinophilic fasciitis accepted for workers’ compensa­tion. Rev Rhum Engl Ed 1997;64:433-434.
12) Schwellnus MP. Skeletal muscle cramps during exercise. Phys Sportsmed 1999;27:109-115.
4) Naramala S, Konala VM, Adapa S, et al. Recurrent inflam­matory myositis as an extra-intestinal manifestation of dormant ulcerative colitis in a patient on long-term mesalamine. Case Rep in Gastrointestinal Med 2019;2019:2090379.
10) Voigt E, Griga A, Tromm MG, et al. Polymyositis of the skeletal muscles as an extraintestinal complication in quiescent ulcerative colitis. Int J Colorectal Dis 1999;14:304-307.
5) Bourikas LA, Papadakis KA. Musculoskeltal manifestations of inflammatory bowel disease. Inflamm Bowel Dis 2009;15:1915-1924.
11) Bataduwaarachchi VR, Fenandopulle N, Liyanage U, et al. The concurrent association of inflammatory polymyositis and Crohn’‍s ileo-colitis in a Sri Lankan man: a case report of a rare association and literature review. BMC Gastroenterol 2014;14:35.
8) Ahmed S, Kitchen J, Hamilton S, et al. A case of polyarteritis nodosa limited to the right calf muscles, fascia, and skin: a case report. J Med Case Rep 2011;5:450.
2) Voigt E, Griga T, Tromm A, et al. Polymyositis of the skeletal muscles as an extraintestinal complication in quiescent ulcerative colitis. Int J Colorectal Dis 1999;14:304-307.
18) Ullrich S, Schinke S, Both M, et al. Refractory central nervous system vasculitis and gastrocnemius myalgia syndrome in Crohn’s disease successfully treated with anti-tumor necrosis factor-alpha antibody. Semin Arthritis Rheum 2009;38:337-347.
19) Drabble EM, Gani JS. Acute gastrocnemius myositis. Another extraintestinal manifestation of Crohn’s disease. Med J Aust 1992;157:318-320.
7) Christopoulos C, Savva S, Pylarinou S, et al. Localised gastrocnemius myositis in Crohn’s disease. Clin Rheumatol 2003;22:143-145.
16) Christopoulos C, Savva S, Pylarinou S, et al. Localised gastrocnemius myositis in Crohn’s disease. Clin Rheumatol 2003;22:143-145.
14) Vadala di Prampero S, Marino M, Toso F, et al. Isolated bilateral gastrocnemius myositis in Crohn disease successfully treated with adalimumab. Case Rep Gastroenrerol 2016;10:661-667.
15) Mogul Z, Katz S, Bachman TR, et al. Isolated gastrocnemius myositis related to Crohn’s disease. Gastroenterol Hepatol (NY) 2010;6:453-455.
References_xml – reference: 10) Voigt E, Griga A, Tromm MG, et al. Polymyositis of the skeletal muscles as an extraintestinal complication in quiescent ulcerative colitis. Int J Colorectal Dis 1999;14:304-307.
– reference: 8) Ahmed S, Kitchen J, Hamilton S, et al. A case of polyarteritis nodosa limited to the right calf muscles, fascia, and skin: a case report. J Med Case Rep 2011;5:450.
– reference: 15) Mogul Z, Katz S, Bachman TR, et al. Isolated gastrocnemius myositis related to Crohn’s disease. Gastroenterol Hepatol (NY) 2010;6:453-455.
– reference: 14) Vadala di Prampero S, Marino M, Toso F, et al. Isolated bilateral gastrocnemius myositis in Crohn disease successfully treated with adalimumab. Case Rep Gastroenrerol 2016;10:661-667.
– reference: 9) Shimoyama T, Tamura Y, Sakamoto T, et al. Immune-mediated myositis in Crohn’s disease. Muscle Nerve 2009;39:101-105.
– reference: 19) Drabble EM, Gani JS. Acute gastrocnemius myositis. Another extraintestinal manifestation of Crohn’s disease. Med J Aust 1992;157:318-320.
– reference: 1) Lakatos PL, Lakatos L, Kiss LS, et al. Treatment of extraintestinal manifestations in inflammatory bowel disease. Digestion 2012;86:28-35.
– reference: 7) Christopoulos C, Savva S, Pylarinou S, et al. Localised gastrocnemius myositis in Crohn’s disease. Clin Rheumatol 2003;22:143-145.
– reference: 13) Chazerain P, Vigneron AM, Grossin M, et al. Posttraumatic diffuse eosinophilic fasciitis accepted for workers’ compensa­tion. Rev Rhum Engl Ed 1997;64:433-434.
– reference: 2) Voigt E, Griga T, Tromm A, et al. Polymyositis of the skeletal muscles as an extraintestinal complication in quiescent ulcerative colitis. Int J Colorectal Dis 1999;14:304-307.
– reference: 6) Qureshi JA, Staugaitis SM, Calabrese LH, et al. Neurtophilic myositis: an extra-intestinal manifestation of ulcerative colitis. J ‍Clin Rheumatol 2002;8:85-88.
– reference: 4) Naramala S, Konala VM, Adapa S, et al. Recurrent inflam­matory myositis as an extra-intestinal manifestation of dormant ulcerative colitis in a patient on long-term mesalamine. Case Rep in Gastrointestinal Med 2019;2019:2090379.
– reference: 17) Dioszeghy P, Molnar M, Mechler F. Muscle involvement in Crohn disease. Orv Hetil 1994;135:1259-1261.
– reference: 5) Bourikas LA, Papadakis KA. Musculoskeltal manifestations of inflammatory bowel disease. Inflamm Bowel Dis 2009;15:1915-1924.
– reference: 12) Schwellnus MP. Skeletal muscle cramps during exercise. Phys Sportsmed 1999;27:109-115.
– reference: 18) Ullrich S, Schinke S, Both M, et al. Refractory central nervous system vasculitis and gastrocnemius myalgia syndrome in Crohn’s disease successfully treated with anti-tumor necrosis factor-alpha antibody. Semin Arthritis Rheum 2009;38:337-347.
– reference: 3) 山本真義,井上学,立花直子ら.潰瘍性大腸炎に合併しgastrocnemius myalgia syndrome様の症状を呈した非肉芽腫性筋炎の1例.臨床神経 2017;57:71-76.
– reference: 16) Christopoulos C, Savva S, Pylarinou S, et al. Localised gastrocnemius myositis in Crohn’s disease. Clin Rheumatol 2003;22:143-145.
– reference: 11) Bataduwaarachchi VR, Fenandopulle N, Liyanage U, et al. The concurrent association of inflammatory polymyositis and Crohn’‍s ileo-colitis in a Sri Lankan man: a case report of a rare association and literature review. BMC Gastroenterol 2014;14:35.
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SubjectTerms gastrocnemius myalgia syndrome
ステロイド
潰瘍性大腸炎
Title 潰瘍性大腸炎に限局性筋膜炎を合併した1例
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