Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK1 receptor

• Published in: Neurogastroenterology and motility Vol. 22; no. 11; pp. 1183 - e314
• Main Authors: Little, T. J., Gopinath, A., Patel, E., Mcglone, A., Lassman, D. J., D’amato, M., Mclaughlin, J. T., Thompson, D. G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2010
• Subjects: Acetates - metabolism; Adult; Area Under Curve; Carbon Dioxide - metabolism; dexloxiglumide; Female; fructose; galactose; gastric emptying; Gastric Emptying - drug effects; Gastric Emptying - physiology; Gastrointestinal Transit - drug effects; glucose; Hexoses - chemistry; Hexoses - metabolism; Hexoses - pharmacology; Humans; Male; Osmolar Concentration; Patch-Clamp Techniques; Pentanoic Acids - pharmacology; Receptor, Cholecystokinin A - antagonists & inhibitors; Receptor, Cholecystokinin A - physiology; Reproducibility of Results; Structure-Activity Relationship; tagatose

Background  It is widely reported that hexose sugars slow gastric emptying (GE) via osmoreceptor stimulation but this remains uncertain. We evaluated the effects of a panel of hexoses of differing molecular structure, assessing the effects of osmolality, intra‐individual reproducibility and the role...