Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines

• Published in: British journal of pharmacology Vol. 179; no. 14; pp. 3496 - 3511
• Main Authors: Jacobson, Kenneth A., Gao, Zhan‐Guo, Matricon, Pierre, Eddy, Matthew T., Carlsson, Jens
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.07.2022
• Subjects: Adenosine; Adenosine A2A receptors; Aging; Autocrine signalling; Caffeine; Clinical trials; Diabetes mellitus; Drug development; Immunotherapy; Liver diseases; Membrane proteins; Natural products; Neurodegenerative diseases; Paracrine signalling; Xanthines

A long evolution of knowledge of the psychostimulant caffeine led in the 1960s to another purine natural product, adenosine and its A2A receptor. Adenosine is a short‐lived autocrine/paracrine mediator that acts pharmacologically at four different adenosine receptors in a manner opposite to the pan‐...