The lncRNA HNF1A‐AS1 is a negative prognostic factor and promotes tumorigenesis in osteosarcoma

• Published in: Journal of cellular and molecular medicine Vol. 21; no. 11; pp. 2654 - 2662
• Main Authors: Cai, Lijun, Lv, Jinhan, Zhang, Yinquan, Li, Junhong, Wang, Yinong, Yang, Huilin
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.11.2017
• Subjects: Adult; Area Under Curve; biomarker; Bone Neoplasms - blood; Bone Neoplasms - diagnosis; Bone Neoplasms - genetics; Bone Neoplasms - mortality; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Line, Tumor; Cell Proliferation; Disease Progression; Epithelial-Mesenchymal Transition; Female; function; G1 Phase Cell Cycle Checkpoints - genetics; Gene Expression Regulation, Neoplastic; HNF1A‐AS1; Humans; long noncoding RNA; Male; Middle Aged; Original; osteosarcoma; Osteosarcoma - blood; Osteosarcoma - diagnosis; Osteosarcoma - genetics; Osteosarcoma - mortality; Prognosis; Proportional Hazards Models; Risk Factors; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; ROC Curve; long noncoding RNA; biomarker; osteosarcoma; HNF1A-AS1; function

Recent studies have revealed that long noncoding RNA HNF1A‐antisense 1 (HNF1A‐AS1) plays an important role in the development of several human malignancy entities. However, the expression and function of HNF1A‐AS1 in the carcinogenesis and development of osteosarcoma remains unknown. In this study,...