末梢肺に対する経気管支的光線力学的治療の病理所見の検討
末梢肺へ経気管支的に光線力学的治療（photodynamic therapy: PDT）を行った際の肺実質への影響を調査するため，ハイブリッド犬の正常肺に対してPDTを行い肺組織への影響を病理学的に検討した．二頭のハイブリッド犬に対し経気管支鏡的に側射型プラスチックレーザープローブを左右後葉の末梢気管支へ挿入しPDTを施行した．タラポルフィンナトリウム投与後，左右後葉支へ50 J/cm2および100 J/cm2のレーザー照射を行い，7日後に肺を摘出し病理学的にPDTの影響を検討した．PDT施行部に一致して肺胞出血や肉芽の形成，線維芽細胞の増殖やマクロファージの浸潤などが認められた．周囲の気管支...
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| Published in | 日本レーザー医学会誌 Vol. 43; no. 1; pp. 22 - 28 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本レーザー医学会
15.04.2022
日本レーザー医学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0288-6200 1881-1639 |
| DOI | 10.2530/jslsm.jslsm-43_0002 |
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| Abstract | 末梢肺へ経気管支的に光線力学的治療（photodynamic therapy: PDT）を行った際の肺実質への影響を調査するため，ハイブリッド犬の正常肺に対してPDTを行い肺組織への影響を病理学的に検討した．二頭のハイブリッド犬に対し経気管支鏡的に側射型プラスチックレーザープローブを左右後葉の末梢気管支へ挿入しPDTを施行した．タラポルフィンナトリウム投与後，左右後葉支へ50 J/cm2および100 J/cm2のレーザー照射を行い，7日後に肺を摘出し病理学的にPDTの影響を検討した．PDT施行部に一致して肺胞出血や肉芽の形成，線維芽細胞の増殖やマクロファージの浸潤などが認められた．周囲の気管支軟骨や肺胞上皮，臓側胸膜へは影響を認めなかった．PDTの効果範囲は約15 mmだった．末梢肺へのPDTは既存構造への影響は少なく安全に施行可能と考えられた． |
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| AbstractList | 末梢肺へ経気管支的に光線力学的治療（photodynamic therapy: PDT）を行った際の肺実質への影響を調査するため，ハイブリッド犬の正常肺に対してPDTを行い肺組織への影響を病理学的に検討した．二頭のハイブリッド犬に対し経気管支鏡的に側射型プラスチックレーザープローブを左右後葉の末梢気管支へ挿入しPDTを施行した．タラポルフィンナトリウム投与後，左右後葉支へ50 J/cm2および100 J/cm2のレーザー照射を行い，7日後に肺を摘出し病理学的にPDTの影響を検討した．PDT施行部に一致して肺胞出血や肉芽の形成，線維芽細胞の増殖やマクロファージの浸潤などが認められた．周囲の気管支軟骨や肺胞上皮，臓側胸膜へは影響を認めなかった．PDTの効果範囲は約15 mmだった．末梢肺へのPDTは既存構造への影響は少なく安全に施行可能と考えられた． 「要旨」 末梢肺へ経気管支的に光線力学的治療(photodynamic therapy: PDT)を行った際の肺実質への影響を調査するため, ハイブリッド犬の正常肺に対してPDTを行い肺組織への影響を病理学的に検討した. 二頭のハイブリッド犬に対し経気管支鏡的に側射型プラスチックレーザープローブを左右後葉の末梢気管支へ挿入しPDTを施行した. タラポルフィンナトリウム投与後, 左右後葉支へ50J/cm2および100J/cm2のレーザー照射を行い, 7日後に肺を摘出し病理学的にPDTの影響を検討した. PDT施行部に一致して肺胞出血や肉芽の形成, 線維芽細胞の増殖やマクロファージの浸潤などが認められた. 周囲の気管支軟骨や肺胞上皮, 臓側胸膜へは影響を認めなかった. PDTの効果範囲は約15mmだった. 末梢肺へのPDTは既存構造への影響は少なく安全に施行可能と考えられた. |
| Author | 池田, 徳彦 大谷, 圭志 荒井, 恒憲 今井, 健太郎 小野, 祥太郎 小川, 恵美悠 松林, 純 前原, 幸夫 工藤, 勇人 大平, 達夫 |
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| References | 2) Kato H, Furukawa K, Sato M, Okunaka T, Kusunoki Y, Kawahara M, Fukuoka M, Miyazawa T, Yana T, Matsui K, Shiraishi T, Horinouchi H. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorine e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer. 2003; 42: 103-111. 10) Usuda J, Inoue T, Tsuchida T, Ohtani K, Maehara S, Ikeda N, Ohsaki Y, Sasaki T, Oka K. Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study. Photodiagnosis Photodyn Ther. 2020; 30: 101698. 21) Semaan RW, Lee HJ, Feller-Kopman D, Lerner AD, Mallow CM, Thiboutot J, Arias SA, Yarmus LB. Same-day computed tomographic chest imaging for pulmonary nodule targeting with electromagnetic navigation bronchoscopy may decrease unnecessary procedures. Ann Am Thorac Soc. 2016; 13: 2223–2228. 3) Usuda J, Ichinose S, Ishizumi T, Hayashi H, Ohtani K, Maehara S, Ono S, Honda H, Kajiwara N, Uchida O, Tsutsui H, Ohira T, Kato H, Ikeda H. Outcome of photodynamic therapy with NPe6 for bronchogenic carcinomas in central airways more than 1.0 cm in diameter. Clin Cancer Res. 2010; 16: 2198-2204. 15) Fielding DI, Buonaccorsi GA, MacRobert AJ, Hanby AM, Hetzel MR, Bown SG. Fine-needle interstitial photodynamic therapy of the lung parenchyma: Photosensitizer distribution and morphologic effects of treatment. Chest. 1999; 115: 502-510. 1) Furuse K, Fukuoka M, Kato H, Horai T, Kubota K, Kodama N, Kusunoki Y, Takifuji N, Okunaka T, Konaka C. A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. J Clin Oncol. 1993; 11: 1852-1857. 13) Uno Y, Ogawa E, Aiyoshi E, Arai T. A three-compartment pharmacokinetic model to predict the interstitial concentration of talaporfin sodium in the myocardium for photodynamic therapy: A method combining measured fluorescence and analysis of the compartmental origin of the fluorescence. Bioengineering (Basel). 2018; 6: 1. 16) Fielding DI, Buonaccorsi G, Cowley G, Johnston AM, Hughes G, Hetzel MR, Bown SG. Interstitial laser photocoagulation and interstitial photodynamic therapy of normal lung parenchyma in the pig. Lasers Med Sci. 2001; 16: 26-33. 11) 小川, 恵美悠，荒井, 恒憲，臼田 実男，大谷, 圭志，前原, 幸夫，今井, 健太郎，工藤, 勇人，小野, 祥太郎，池田, 徳彦．プラスチック光ファイバーを用いた細径拡散光照射プローブによる光線力学的治療．日レ医誌．2020; 41: 25-29. 19) Kondo K, Miyoshi T, Fujino H, Takizawa H, Imai S, Kobayashi N, Kenzaki K, Sakiyama S, Tangoku A. Photodynamic therapy using a second generation photosensitizer, Talaporfin. Photodiagnosis Photodyn Ther. 2007; 4: 269-274. 7) Kurimoto N, Miyazawa T, Okimasa S, Maeda A, Oiwa H, Miyazu Y, Murayama M. Endobronchial ultrasonography using a guide sheath increases the ability to diagnose peripheral pulmonary lesions endoscopically. Chest. 2004; 126: 959-965. 12) Kimura T, Takatsuki S, Miyoshi S, Takahashi M, Ogawa E, Katsumata Y, Nishiyama T, Nishiyama N, Tanimoto Y, Aizawa Y, Arai T, Fukuda K. Optimal conditions for cardiac catheter ablation using photodynamic therapy. Europace. 2015; 17: 1309-1315. 18) Chatlani PT, Nuutinen PJ, Toda N, Barr H, MacRobert AJ, Bedwell J, Bown SG. Selective necrosis in hamster pancreatic tumours using photodynamic therapy with phthalocyanine photosensitization. Br J Surg. 1992; 79: 786-790. 4) Furukawa K, Kato H, Konaka C, Okunaka T, Usuda J, Ebihara Y. Locally recurrent central-type early stage lung cancer <1.0 cm in diameter after complete remission by photodynamic therapy. Chest. 2005; 128: 3269-3275. 6) Harris K, Puchalski J, Sterman D. Recent advances in bronchoscopic treatment of peripheral lung cancers. Chest. 2017; 151: 674-685. 20) Musani AI, Veir JK, Huang Z, Lei T, Groshong S, Worley D. Photodynamic therapy via navigational bronchoscopy for peripheral lung cancer in dogs. Lasers Surg Med. 2018; 50: 483-490. 8) Asano F, Matsuno Y, Tsuzuku A, Anzai M, Shinagawa N, Yamazaki K, Ishida T, Moriya H. Diagnosis of peripheral pulmonary lesions using a bronchoscope insertion guidance system combined with endobronchial ultrasonography with a guide sheath. Lung Cancer. 2008; 60: 366-373. 14) Mitra S, Foster TH. In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6. Neoplasia. 2008; 10: 429-438. 17) Barr H, Tralau CJ, Boulos PB, MacRobert AJ, Krasner N, Phillips D, Bown SG. Selective necrosis in dimethylhydrazine-induced rat colon tumors using phthalocyanine photodynamic therapy. Gastroenterology. 1990; 98: 1532-1537. 5) Okunaka T, Kato H, Tsutsui H, Ishizumi T, Ichinose S, Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer. 2004; 43: 77-82. 9) Ishida T, Asano F, Yamazaki K, Shinagawa N, Oizumi S, Moriya H, Munakata M, Nishimura MVirtual Navigation in Japan Trial Group. Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions: A randomised trial. Thorax. 2011; 66: 1072-1077. 22) Flenaugh EL, Mohammed KH. Initial experience using 4D electromagnetic navigation bronchoscopy system with tip tracked instruments for localization of peripheral lung nodules. Internet J Pulmon Med. 2016; 18: 1–7. |
| References_xml | – reference: 17) Barr H, Tralau CJ, Boulos PB, MacRobert AJ, Krasner N, Phillips D, Bown SG. Selective necrosis in dimethylhydrazine-induced rat colon tumors using phthalocyanine photodynamic therapy. Gastroenterology. 1990; 98: 1532-1537. – reference: 5) Okunaka T, Kato H, Tsutsui H, Ishizumi T, Ichinose S, Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer. 2004; 43: 77-82. – reference: 21) Semaan RW, Lee HJ, Feller-Kopman D, Lerner AD, Mallow CM, Thiboutot J, Arias SA, Yarmus LB. Same-day computed tomographic chest imaging for pulmonary nodule targeting with electromagnetic navigation bronchoscopy may decrease unnecessary procedures. Ann Am Thorac Soc. 2016; 13: 2223–2228. – reference: 9) Ishida T, Asano F, Yamazaki K, Shinagawa N, Oizumi S, Moriya H, Munakata M, Nishimura MVirtual Navigation in Japan Trial Group. Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions: A randomised trial. Thorax. 2011; 66: 1072-1077. – reference: 13) Uno Y, Ogawa E, Aiyoshi E, Arai T. A three-compartment pharmacokinetic model to predict the interstitial concentration of talaporfin sodium in the myocardium for photodynamic therapy: A method combining measured fluorescence and analysis of the compartmental origin of the fluorescence. Bioengineering (Basel). 2018; 6: 1. – reference: 15) Fielding DI, Buonaccorsi GA, MacRobert AJ, Hanby AM, Hetzel MR, Bown SG. Fine-needle interstitial photodynamic therapy of the lung parenchyma: Photosensitizer distribution and morphologic effects of treatment. Chest. 1999; 115: 502-510. – reference: 14) Mitra S, Foster TH. In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6. Neoplasia. 2008; 10: 429-438. – reference: 3) Usuda J, Ichinose S, Ishizumi T, Hayashi H, Ohtani K, Maehara S, Ono S, Honda H, Kajiwara N, Uchida O, Tsutsui H, Ohira T, Kato H, Ikeda H. Outcome of photodynamic therapy with NPe6 for bronchogenic carcinomas in central airways more than 1.0 cm in diameter. Clin Cancer Res. 2010; 16: 2198-2204. – reference: 7) Kurimoto N, Miyazawa T, Okimasa S, Maeda A, Oiwa H, Miyazu Y, Murayama M. Endobronchial ultrasonography using a guide sheath increases the ability to diagnose peripheral pulmonary lesions endoscopically. Chest. 2004; 126: 959-965. – reference: 1) Furuse K, Fukuoka M, Kato H, Horai T, Kubota K, Kodama N, Kusunoki Y, Takifuji N, Okunaka T, Konaka C. A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. J Clin Oncol. 1993; 11: 1852-1857. – reference: 12) Kimura T, Takatsuki S, Miyoshi S, Takahashi M, Ogawa E, Katsumata Y, Nishiyama T, Nishiyama N, Tanimoto Y, Aizawa Y, Arai T, Fukuda K. Optimal conditions for cardiac catheter ablation using photodynamic therapy. Europace. 2015; 17: 1309-1315. – reference: 10) Usuda J, Inoue T, Tsuchida T, Ohtani K, Maehara S, Ikeda N, Ohsaki Y, Sasaki T, Oka K. Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study. Photodiagnosis Photodyn Ther. 2020; 30: 101698. – reference: 11) 小川, 恵美悠，荒井, 恒憲，臼田 実男，大谷, 圭志，前原, 幸夫，今井, 健太郎，工藤, 勇人，小野, 祥太郎，池田, 徳彦．プラスチック光ファイバーを用いた細径拡散光照射プローブによる光線力学的治療．日レ医誌．2020; 41: 25-29. – reference: 18) Chatlani PT, Nuutinen PJ, Toda N, Barr H, MacRobert AJ, Bedwell J, Bown SG. Selective necrosis in hamster pancreatic tumours using photodynamic therapy with phthalocyanine photosensitization. Br J Surg. 1992; 79: 786-790. – reference: 19) Kondo K, Miyoshi T, Fujino H, Takizawa H, Imai S, Kobayashi N, Kenzaki K, Sakiyama S, Tangoku A. Photodynamic therapy using a second generation photosensitizer, Talaporfin. Photodiagnosis Photodyn Ther. 2007; 4: 269-274. – reference: 2) Kato H, Furukawa K, Sato M, Okunaka T, Kusunoki Y, Kawahara M, Fukuoka M, Miyazawa T, Yana T, Matsui K, Shiraishi T, Horinouchi H. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorine e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer. 2003; 42: 103-111. – reference: 22) Flenaugh EL, Mohammed KH. Initial experience using 4D electromagnetic navigation bronchoscopy system with tip tracked instruments for localization of peripheral lung nodules. Internet J Pulmon Med. 2016; 18: 1–7. – reference: 6) Harris K, Puchalski J, Sterman D. Recent advances in bronchoscopic treatment of peripheral lung cancers. Chest. 2017; 151: 674-685. – reference: 4) Furukawa K, Kato H, Konaka C, Okunaka T, Usuda J, Ebihara Y. Locally recurrent central-type early stage lung cancer <1.0 cm in diameter after complete remission by photodynamic therapy. Chest. 2005; 128: 3269-3275. – reference: 16) Fielding DI, Buonaccorsi G, Cowley G, Johnston AM, Hughes G, Hetzel MR, Bown SG. Interstitial laser photocoagulation and interstitial photodynamic therapy of normal lung parenchyma in the pig. Lasers Med Sci. 2001; 16: 26-33. – reference: 8) Asano F, Matsuno Y, Tsuzuku A, Anzai M, Shinagawa N, Yamazaki K, Ishida T, Moriya H. Diagnosis of peripheral pulmonary lesions using a bronchoscope insertion guidance system combined with endobronchial ultrasonography with a guide sheath. Lung Cancer. 2008; 60: 366-373. – reference: 20) Musani AI, Veir JK, Huang Z, Lei T, Groshong S, Worley D. Photodynamic therapy via navigational bronchoscopy for peripheral lung cancer in dogs. Lasers Surg Med. 2018; 50: 483-490. |
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| Title | 末梢肺に対する経気管支的光線力学的治療の病理所見の検討 |
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| ispartofPNX | 日本レーザー医学会誌, 2022/04/15, Vol.43(1), pp.22-28 |
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