A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor - Zhao, Xin-mei; Hauache, Omar; Goldsmith, Paul K.; Collins, Regina; Spiegel, Allen M. (FEBS letters, 1999)
Keywords: ADH, autosomal dominant hypocalcemia; Binding Sites; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Calcium-sensing receptor; CaR, Ca2+ receptor; Cell Line, Transformed; Cell Membrane - metabolism; Constitutive activation; DMEM, Dulbecco's modified Eagle's medium; ECD, extracellular domain; Enzyme-Linked Immunosorbent Assay; FBS, fetal bovine serum; G protein-coupled receptor; GPCR, G protein-coupled receptor; hCaR, human Ca2+ receptor; Humans; Hydrolysis; mGluR, metabotropic glutamate receptor; Mutation, Missense; PCR, polymerase chain reaction; Phosphatidylinositols - metabolism; PI, phosphoinositide; Signal Transduction; TM, transmembrane domain