Salivary metabolites as novel independent predictors of radiation pneumonitis

• Published in: Journal of cancer research and clinical oncology Vol. 149; no. 19; pp. 17559 - 17566
• Main Authors: Shiraishi, Sachika, Sugimoto, Masahiro, Tokuuye, Koichi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Butyrates; Cancer Research; Capillary electrophoresis; Carcinoma, Non-Small-Cell Lung - radiotherapy; Female; Hematology; Humans; Internal Medicine; logit analysis; Lung cancer; lung neoplasms; Lung Neoplasms - complications; Lung Neoplasms - radiotherapy; lungs; Male; mass spectrometry; Mass spectroscopy; Medicine; Medicine & Public Health; Metabolites; Metabolomics; Middle Aged; Non-small cell lung carcinoma; Oncology; Patients; pneumonia; Pneumonia - complications; Pneumonitis; Prognosis; propionic acid; Radiation Injuries; Radiation Pneumonitis - etiology; Radiation therapy; radiotherapy; Radiotherapy Dosage; Retrospective Studies; Risk factors; Saliva; Small cell lung carcinoma; Thorax; Toxicity; Metabolomics; Prognosis; Saliva; Radiation pneumonitis

Purpose Radiotherapy is an integral treatment for non-small cell lung cancer (NSCLC); however, radiation-induced toxicities such as radiation pneumonitis (RP) present a considerable challenge. Herein, we aimed to evaluate the potential of salivary metabolomics as an independent risk factor for predi...