１型糖尿病若年患者におけるカルボニル／酸化ストレスの評価

糖尿病合併症の成因としてカルボニル／酸化ストレスの関与がおもに成人領域で注目されている。われわれは，１型糖尿病若年患者が受けるカルボニル／酸化ストレスについて検討した。１型糖尿病患者38名（男／女：17/21，年齢12.8±4.5歳，罹病期間：5.7±4.3年［平均±SD］），正常対照60名（男／女：28/32，年齢：11.4±4.5歳）の早朝尿中のpentosidine， pyrraline（カルボニルストレスマーカー)，8-OHdG，acrolein-lysine（酸化ストレスマーカー）濃度を計測した。１型糖尿病患者では尿pentosidine，8-OHdG，acrolein-lysine...

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Published in日本小児腎臓病学会雑誌 Vol. 16; no. 2; pp. 143 - 150
Main Authors 平岡, 政弘, 川上, 寿子, 関根, 恭一, 内山, 真由美, 畑, 郁江, 巨田, 尚子, 佐藤, 周子, 眞弓, 光文, 轟, 夕起子, 塚原, 宏一, 三浦, 雅一
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本小児腎臓病学会 2003
日本小児腎臓病学会
Subjects
カルボニルストレス
血管内皮機能不全
酸化ストレス
１型糖尿病
Online AccessGet full text
ISSN0915-2245
1881-3933
DOI10.3165/jjpn.16.143

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Abstract 糖尿病合併症の成因としてカルボニル／酸化ストレスの関与がおもに成人領域で注目されている。われわれは，１型糖尿病若年患者が受けるカルボニル／酸化ストレスについて検討した。１型糖尿病患者38名（男／女：17/21，年齢12.8±4.5歳，罹病期間：5.7±4.3年［平均±SD］），正常対照60名（男／女：28/32，年齢：11.4±4.5歳）の早朝尿中のpentosidine， pyrraline（カルボニルストレスマーカー)，8-OHdG，acrolein-lysine（酸化ストレスマーカー）濃度を計測した。１型糖尿病患者では尿pentosidine，8-OHdG，acrolein-lysineは正常対照よりも有意に高かった。pentosidine はpyrraline，8-OHdG，acrolein-lysineと，pyrralineはacrolein-lysineと有意に正相関した。pentosidine，8-OHdG，acrolein-lysineは尿中アルブミンと有意に正相関した。微小アルブミン尿陽性患者（≥15mg/g Cr; 11名）では，すべてのマーカーが微小アルブミン尿陰性患者および正常対照よりも有意に高かった。今回の研究により，１型糖尿病若年患者では酸化ストレスとそれに連動したカルボニルストレスが亢進していることが示された。
AbstractList 糖尿病合併症の成因としてカルボニル／酸化ストレスの関与がおもに成人領域で注目されている。われわれは，１型糖尿病若年患者が受けるカルボニル／酸化ストレスについて検討した。１型糖尿病患者38名（男／女：17/21，年齢12.8±4.5歳，罹病期間：5.7±4.3年［平均±SD］），正常対照60名（男／女：28/32，年齢：11.4±4.5歳）の早朝尿中のpentosidine， pyrraline（カルボニルストレスマーカー)，8-OHdG，acrolein-lysine（酸化ストレスマーカー）濃度を計測した。１型糖尿病患者では尿pentosidine，8-OHdG，acrolein-lysineは正常対照よりも有意に高かった。pentosidine はpyrraline，8-OHdG，acrolein-lysineと，pyrralineはacrolein-lysineと有意に正相関した。pentosidine，8-OHdG，acrolein-lysineは尿中アルブミンと有意に正相関した。微小アルブミン尿陽性患者（≥15mg/g Cr; 11名）では，すべてのマーカーが微小アルブミン尿陰性患者および正常対照よりも有意に高かった。今回の研究により，１型糖尿病若年患者では酸化ストレスとそれに連動したカルボニルストレスが亢進していることが示された。
糖尿病合併症の成因としてカルボニル/酸化ストレスの関与がおもに成人領域で注目されている. われわれは, 1型糖尿病若年患者が受けるカルボニル/酸化ストレスについて検討した. 1型糖尿病患者38名(男/女:17/21, 年齢:12.8±4.5歳, 罹病期間:5.7±4.3年[平均±SD]), 正常対照60名(男/女:28/32, 年齢:11.4±4.5歳)の早朝尿中のpentosidine, pyrraline(カルボニルストレスマーカー), 8-OHdG, acrolein-lysine(酸化ストレスマーカー)濃度を計測した. 1型糖尿病患者では尿pentosidine, 8-OHdG, acrolein-lysineは正常対照よりも有意に高かった. pentosidineはpyrraline, 8-OHdG, acrolein-lysineと, pyrralineはacrolein-lysineと有意に正相関した. pentosidine, 8-OHdG, acrolein-lysineは尿中アルブミンと有意に正相関した. 微小アルブミン尿陽性患者(≧15mg/g Cr;11名)では, すべてのマーカーが微小アルブミン尿陰性患者および正常対照よりも有意に高かった. 今回の研究により, 1型糖尿病若年患者では酸化ストレスとそれに連動したカルボニルストレスが亢進していることが示された.
Author 塚原, 宏一
眞弓, 光文
川上, 寿子
畑, 郁江
巨田, 尚子
関根, 恭一
轟, 夕起子
平岡, 政弘
内山, 真由美
佐藤, 周子
三浦, 雅一
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1) Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes 48: 1-9, 1999.
References_xml – reference: 37) Miyata T, Ishiguro N, Yasuda Y, Ito T, Nangaku M, Iwata H, Kurokawa K. Increased pentosidine, an advanced glycation end product, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory markers. Biochem Biophys Res Commun 244: 45-49, 1998.
– reference: 2) Toyokuni S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49: 91-102, 1999.
– reference: 5) Bucala R, Vlassara H. Advanced glycosylation end products in diabetic renal and vascular disease. Am J Kidney Dis 26: 875-888, 1995.
– reference: 39) Nakamura S, Makita Z, Ishikawa S, Yasumura K, Fujii W, Yanagisawa K, Kawata T, Koike T. Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation. Diabetes 46: 895-899, 1997.
– reference: 3) Jiang M, Tsukahara H, Hata I, Toyooka M, Todoroki Y, Hiraoka M, Mayumi M. Biomarkers for oxidative stress: Implications and applications in clinical practice. Annual Research Reports of Renal Anemia Foundation 255-262, 2002.
– reference: 1) Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes 48: 1-9, 1999.
– reference: 31) Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49: 1304-1313, 1996.
– reference: 22) Schiekofer S, Balletshofer B, Andrassy M, Bierhaus A, Nawroth PP. Endothelial dysfunction in diabetes mellitus. Semin Thromb Hemost 26: 503-511, 2000.
– reference: 35) Takahashi M, Suzuki M, Kushida K, Miyamoto S, Inoue T. Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis. Br J Rheumatol 36: 637-642, 1997.
– reference: 8) Makita Z, Bucala R, Rayfield EJ, Friedman EA, Kaufman AM, Korbet SM, Barth RH, Winston JA, Fuh H, Manogue KR, Cerami A, Vlassara H. Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure. Lancet 343: 1519-1522, 1994.
– reference: 21) Telci A, Cakatay U, Salman S, Satman I, Sivas A. Oxidative protein damage in early stage type 1 diabetic patients. Diabetes Res Clin Prac 50: 213-223, 2000.
– reference: 23) Pomilio M, Mohn A, Verrotti A, Chiarelli F. Endothelial dysfunction in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 15: 343-361, 2002.
– reference: 16) Chiarelli F, Catino M, Tumini S, Cipollone F, Mezzetti A, Vanelli M, Verrotti A. Advanced glycation end products in adolescents and young adults with diabetic angiopathy. Pediatr Nephrol 14: 841-846, 2000.
– reference: 30) Hayase F, Nagaraj RH, Miyata S, Njoroge FG, Monnier VM. Aging of proteins: Immunological detection of a glucose-derived pyrrole formed during Maillard reaction in vivo. J Biol Chem 263: 3758-3764, 1989.
– reference: 34) Miyata T, Inagi R, Asahi K, Yamada Y, Horie K, Sakai H, Uchida K, Kurokawa K. Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids. FEBS Lett 437: 24-28, 1998.
– reference: 27) Urata Y, Yamaguchi M, Higashiyama Y, Ihara Y, Goto S, Kuwano M, Horiuchi S,Sumikawa K, Kondo T. Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW 264.7 mouse macrophages. Free Radic Biol Med 32: 688-701, 2002.
– reference: 4) Vlassara H, Bucala R, Striker L. Pathogenic effects of advanced glycosylation: Biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 70: 138-151, 1994.
– reference: 11) Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A, Jiang M, Hiraoka M, Nambu M, Deguchi Y, Mayumi M. Increased oxidative stress in childhood atopic dermatitis. Life Sci 69: 223-228, 2001.
– reference: 25) Wautier JL, Wautier MP, Schmidt AM, Anderson GM, Hori O, Zoukourian C, Capron L, Chappey O, Yan SD, Brett J, Guillausseau PJ, Stern D. Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: A link between surface-associated AGEs and diabetic complications. Proc Natl Acad Sci USA 91: 7742-7746, 1999.
– reference: 26) Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the receptor for advanced glycation end products triggers a p21ras-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem 272: 17810-17814, 1997.
– reference: 38) Vlassara H, Striker LJ, Teichberg S, Fuh H, Li YM, Steffes M. Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats. Proc Natl Acad Sci USA 91: 11704-11708, 1994.
– reference: 17) Misselwitz J, Franke S, Kauf E, John U, Stein G. Advanced glycation end products in children with chronic renal failure and type 1 diabetes. Pediatr Nephrol 17: 316-321, 2002.
– reference: 19) Dominguez C, Ruiz E, Gussinye M, Carrascosa A. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care 21: 1736-1742, 1998.
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糖尿病合併症の成因としてカルボニル/酸化ストレスの関与がおもに成人領域で注目されている. われわれは, 1型糖尿病若年患者が受けるカルボニル/酸化ストレスについて検討した. 1型糖尿病患者38名(男/女:17/21, 年齢:12.8±4.5歳, 罹病期間:5.7±4.3年[平均±SD]),...
SourceID medicalonline
jstage
SourceType Publisher
StartPage 143
SubjectTerms カルボニルストレス
血管内皮機能不全
酸化ストレス
１型糖尿病
Title １型糖尿病若年患者におけるカルボニル／酸化ストレスの評価
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http://mol.medicalonline.jp/en/journal/download?GoodsID=eb6jpene/2003/001602/014&name=0143-0150j
Volume 16
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