「口腔細菌─ウイルス─宿主相互作用」の視点に立った感染症の発症と増悪機序
「はじめに」 医学の進歩の歴史は, 感染症との戦いの歴史と言っても過言ではない. ジェンナーによるワクチンの開発やフレミングによるペニシリンの発見に続き, 多くのワクチンや薬が開発され感染症は制圧されると思われた. しかし, 新型インフルエンザやエボラ出血熱などの新たな感染症の発生やAIDSの蔓延, さらには結核の再流行など, 感染症は人類を脅かし続けている. 今年に入り, 新型コロナウイルス(SARS-CoV-2)の爆発的な感染拡大は人類の社会生活を激変させてしまった. 加えて, 高齢化の進むわが国では, 日和見・院内感染に加え誤嚥性肺炎など, 口腔常在菌が原因となる感染症への対策が求められ...
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| Published in | 歯科薬物療法 Vol. 39; no. 3; pp. 95 - 103 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本歯科薬物療法学会
2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0288-1012 1884-4928 |
| DOI | 10.11263/jsotp.21.03 |
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| Abstract | 「はじめに」 医学の進歩の歴史は, 感染症との戦いの歴史と言っても過言ではない. ジェンナーによるワクチンの開発やフレミングによるペニシリンの発見に続き, 多くのワクチンや薬が開発され感染症は制圧されると思われた. しかし, 新型インフルエンザやエボラ出血熱などの新たな感染症の発生やAIDSの蔓延, さらには結核の再流行など, 感染症は人類を脅かし続けている. 今年に入り, 新型コロナウイルス(SARS-CoV-2)の爆発的な感染拡大は人類の社会生活を激変させてしまった. 加えて, 高齢化の進むわが国では, 日和見・院内感染に加え誤嚥性肺炎など, 口腔常在菌が原因となる感染症への対策が求められている. 多くの疾患の病因が分子レベルで解明され, 遺伝子治療や再生医療を始めとする最先端医療がおこなわれている今日においても, ウイルス感染症, ことに潜伏感染ウイルスに対する効果的な治療法はない. |
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| AbstractList | 「はじめに」 医学の進歩の歴史は, 感染症との戦いの歴史と言っても過言ではない. ジェンナーによるワクチンの開発やフレミングによるペニシリンの発見に続き, 多くのワクチンや薬が開発され感染症は制圧されると思われた. しかし, 新型インフルエンザやエボラ出血熱などの新たな感染症の発生やAIDSの蔓延, さらには結核の再流行など, 感染症は人類を脅かし続けている. 今年に入り, 新型コロナウイルス(SARS-CoV-2)の爆発的な感染拡大は人類の社会生活を激変させてしまった. 加えて, 高齢化の進むわが国では, 日和見・院内感染に加え誤嚥性肺炎など, 口腔常在菌が原因となる感染症への対策が求められている. 多くの疾患の病因が分子レベルで解明され, 遺伝子治療や再生医療を始めとする最先端医療がおこなわれている今日においても, ウイルス感染症, ことに潜伏感染ウイルスに対する効果的な治療法はない. |
| Author | 今井, 健一 |
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| Copyright | 2020 日本歯科薬物療法学会 |
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| DOI | 10.11263/jsotp.21.03 |
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Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications. Virology. 2015；474：65-81. 9) de Melo Neto JP, Melo MS, dos Santos-Pereira SA, Martinez EF, Okajima LS, Saba-Chujfi E. Periodontal infections and community-acquired pneumonia：a case-control study. Eur J Clin Microbiol Infect Dis. 2013；32：27-32. 2) Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19：consider cytokine storm syndromes and immunosuppression. Lancet. 2020；395（10229）：1033-34. 23) Giacaman RA, Nobbs AH, Ross KF, Herzberg MC. Porphyromonas gingivalis selectively up-regulates the HIV-1 coreceptor CCR5 in oral keratinocytes. J. Immunol. 2007；179：2542-50. 15) Takahashi Y, Watanabe N, Kamio N, Kobayashi R, Iinuma T, Imai K. Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19. J Oral Sci. 2020；in press. 24) Imai K, Ochiai K, Okamoto T. Reactivation of latent HIV-1 infection by the periodontopathic bacterium Porphyromonas gingivalis involves histone modification. J Immunol. 2009；182（6）：3688-95. 36) Makino K, Takeichi O, Hatori K, Imai K, Ochiai K, Ogiso B. Epstein-barr virus infection in chronically inflamed periapical granulomas.PLoS One. 2015；10（4）：e0121548. 3) Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019（COVID-19）Outbreak in ChinaSummary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020；323（13）：1239-42. 8) Awano S, Ansai T, Takata Y, Soh I, Akifusa S, Hamasaki T, et al. Oral health and mortality risk from pneumonia in the elderly. J Dent Res. 2008；87：334-39. 34) Kato A, Imai K, Ochiai K, Ogata Y. Higher prevalence of Epstein-Barr virus DNA in deeper periodontal pockets of chronic periodontitis in Japanese patients. PLoS One. 2013；8（8）：e71990. 46) Imai K, Ogata Y. How dose Epstein-Barr virus contribute to chronic periodontitis?. Int. J. Moi. Sci. 2020；21（6）：E1940. 12) Smith JC, Sausville EL, Girish V, Yuan ML, Vasudevan A, John KM, el al. Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract. Developmental Cell. 2020；53：514-29. 35) Kato A, Imai K, Ochiai K, Ogata Y. Prevalence and quantitative analysis of Epstein - Barr virus DNA and Porphyromonas gingivalis associated with Japanese chronic periodontitis patients. Clin Oral Investig. 2015；19（7）：1605-10. 20) Maticic M, Poljak M, Kramar B, Tomazic J, Vidmar L, Zakotnik B, et al. Proviral HIV-1 DNA in gingival crevicular fluid of HIV-1-infected patients in various stages of HIV disease. J. Dent. Res. 2000；79：1496-501. 29) Layne SP, Beugelsdijk TJ, Patel CK, Taubenberger JK, Cox NJ, Gust ID, et al. A global lab against influenza. Science. 2001；293：1729. 40) Makino K, Takeichi O, Imai K, Inoue H, Hatori K, Himi K, et al. Porphyromonas endodontalis reactivates latent Epstein-Barr virus. Int Endod J. 2018；51（12）：1410-19. 30) Tashiro M, Ciborowski P, Reinacher M, Pulverer G, Klenk HD, Rott R. Synergistic role of staphylococcal proteases in the induction of influenza virus pathogenicity. Virology. 1987；157：421-30. 22) Jotwani R, Muthukuru M, Cutler CW. Cutler. Increase in HIV receptors/co-receptors//-defensins in inflamed human gingiva. J. Dent. Res. 2004；83：371-77. 7) Akata K, Yatera K, Yamasaki K, Kawanami T, Naito K, Noguchi S, et al. The significance of oral streptococci in patients with pneumonia with risk factors for aspiration：the bacterial floral analysis of 16S ribosomal RNA gene using bronchoalveolar lavage fluid. BMC Pulm Med. 2016；16：79. 27) Morris TL, Arnold RR, Webster-Cyriaque J. Signaling cascades triggered by bacterial metabolic end products during reactivation of Kaposi’s sarcoma-associated herpesvirus. J Virol. 2007；81：6032-42. 25) Imai K, Okamoto T, Ochiai K. Involvement of Sp1 in butyric acid-induced HIV-1 gene expression. Cell Physiol Biochem. 2015；37（3）：853-65. 10) Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical Course and Risk Factors for Mortality of Adult Inpatients With COVID-19 in Wuhan, China：A Retrospective Cohort Study. Lancet. 2020；395（10229）：1054-62. 21) Chattin BR, Ishihara K, Okuda K, Hirai Y, Ishikawa T. Specific microbial colonizations in the periodontal sites of HIV-infected subjects. Microbiol. Immunol. 1999；43：847-52. 13) Hayata M, Watanabe N, Tamura M, Kamio N, Tanaka H, Nodomi K, et al. The Periodontopathic Bacterium Fusobacterium nucleatum Induced Proinflammatory Cytokine Production by Human Respiratory Epithelial Cell Lines and in the Lower Respiratory Organs in Mice. Cell Physiol Biochem. 2019；53：49-61. 39) Imai K, Inoue H, Tamura M, Cueno ME, Inoue H, Takeichi O, et al. The periodontal pathogen Porphyromonas gingivalis induces the Epstein-Barr Virus lytic switch transactivator ZEBRA by histone modification. Biochimie. 2012；94（3）：839-46. 5) 今井健一，小林隆太郎．新型コロナウイルスのBiology─ウイルスの特徴から口腔との関連まで─．歯界展望．2020；136（1）：4-16. 19) Simpson TC, Weldon JC, Worthington HV, Needleman I, Wild SH, Moles DR, et al. Treatment of Periodontal Disease for Glycaemic Control in People With Diabetes Mellitus. Cochrane Database Syst Rev. 2015；CD004714. 45) Sunde PT, Olsen I, Enersen M, Grinde B. Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy. J Clin Virol. 2008；42：176-78. 1) Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020；181（2）：271-80. 16) Yoneyama T, Yoshida M, Matsui T, Sasaki H. Oral care and pneumonia. Lancet. 1999；354：515. 42) Koike R, Nodomi K, Watanabe N, Ogata Y, Takeichi O, Takei M, et al. Butyric acid in saliva of chronic periodontitis patients induces transcription of the EBV lytic switch activator BZLF1：A Pilot study. In Vivo. 2020；34（2）：587-94. 28) Imai K, Victriano AF, Ochiai K, Okamoto T. Microbial Interaction of Periodontopathic Bacterium Porphyromonas gingivalis and HIV- Possible Causal Link of Periodontal Diseases to AIDS Progression-. Curr HIV Res. 2012；10（3）：238-44. 33) Slots J. Human viruses in periodontitis. Periodontol. 2000；53：89-110. 38) Kato A, Imai K, Sato H, Ogata Y. Prevalence of Epstein-Barr virus DNA and Porphyromonas gingivalis in Japanese Peri-implantitis patients. BMC Oral Health. 2017；17（1）：148. 6) Yamasaki K, Kawanami T, Yatera K, Fukuda K, Noguchi S, Nagata S, et al. Significance of anaerobes and oral bacteria in community-acquired pneumonia. PLoS One. 2013；8（5）：e63103. 43) Ikeda Y, Kato A, Imai K, Ogata Y. Quantitative Changes of P. gingivalis and EBV DNA in Saliva before and after Initial Periodontal Therapy in Chronic Periodontitis Patients. Int J Oral-Med Sci. 2020；19（1）：12-18. 37) Himi K, Takeichi O, Imai K, Hatori K, Tamura T, Ogiso B. Epstein-Barr virus reactivation by persistent apical periodontal pathogens. Int Endod J. 2020；53（4）：492-505. 31) Kamio N, Imai K, Shimizu K, Cueno ME, Tamura M, Saito Y, et al. Neuraminidase-producing oral mitis group streptococci potentially contribute to influenza viral infection and reduction in antiviral efficacy of zanamivir. Cell Mol Life Sci. 2015；72（2）：357-66. 14) Koike R, Cueno ME, Nodomi K, Tamura M, Kamio N, Tanaka H, et al. Heat-killed Fusobacterium nucleatum triggers varying heme-related inflammatory and stress responses depending on primary human respiratory epithelial cell type：An insight into the virulence potential of fusobacterial adhesins. Moleclues. 2020；in press. 41) Watanabe N, Nodomi K, Koike R, Kato A, Takeichi O, Kotani AI, et al. EBV LMP1 in gingival epithelium potentially contributes to human chronic periodontitis via inducible IL8 production. In Vivo. 2019；33（6）：1793-800. 11) Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H,et al. Clinical Course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China：a single-centered, retrospective, observational study. Lancet Respir Med. 2020；8：475-81. |
| References_xml | – reference: 11) Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H,et al. Clinical Course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China：a single-centered, retrospective, observational study. Lancet Respir Med. 2020；8：475-81. – reference: 38) Kato A, Imai K, Sato H, Ogata Y. Prevalence of Epstein-Barr virus DNA and Porphyromonas gingivalis in Japanese Peri-implantitis patients. BMC Oral Health. 2017；17（1）：148. – reference: 6) Yamasaki K, Kawanami T, Yatera K, Fukuda K, Noguchi S, Nagata S, et al. Significance of anaerobes and oral bacteria in community-acquired pneumonia. PLoS One. 2013；8（5）：e63103. – reference: 8) Awano S, Ansai T, Takata Y, Soh I, Akifusa S, Hamasaki T, et al. Oral health and mortality risk from pneumonia in the elderly. J Dent Res. 2008；87：334-39. – reference: 5) 今井健一，小林隆太郎．新型コロナウイルスのBiology─ウイルスの特徴から口腔との関連まで─．歯界展望．2020；136（1）：4-16. – reference: 15) Takahashi Y, Watanabe N, Kamio N, Kobayashi R, Iinuma T, Imai K. Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19. J Oral Sci. 2020；in press. – reference: 39) Imai K, Inoue H, Tamura M, Cueno ME, Inoue H, Takeichi O, et al. The periodontal pathogen Porphyromonas gingivalis induces the Epstein-Barr Virus lytic switch transactivator ZEBRA by histone modification. Biochimie. 2012；94（3）：839-46. – reference: 43) Ikeda Y, Kato A, Imai K, Ogata Y. Quantitative Changes of P. gingivalis and EBV DNA in Saliva before and after Initial Periodontal Therapy in Chronic Periodontitis Patients. Int J Oral-Med Sci. 2020；19（1）：12-18. – reference: 42) Koike R, Nodomi K, Watanabe N, Ogata Y, Takeichi O, Takei M, et al. Butyric acid in saliva of chronic periodontitis patients induces transcription of the EBV lytic switch activator BZLF1：A Pilot study. In Vivo. 2020；34（2）：587-94. – reference: 31) Kamio N, Imai K, Shimizu K, Cueno ME, Tamura M, Saito Y, et al. Neuraminidase-producing oral mitis group streptococci potentially contribute to influenza viral infection and reduction in antiviral efficacy of zanamivir. Cell Mol Life Sci. 2015；72（2）：357-66. – reference: 25) Imai K, Okamoto T, Ochiai K. Involvement of Sp1 in butyric acid-induced HIV-1 gene expression. Cell Physiol Biochem. 2015；37（3）：853-65. – reference: 9) de Melo Neto JP, Melo MS, dos Santos-Pereira SA, Martinez EF, Okajima LS, Saba-Chujfi E. Periodontal infections and community-acquired pneumonia：a case-control study. Eur J Clin Microbiol Infect Dis. 2013；32：27-32. – reference: 29) Layne SP, Beugelsdijk TJ, Patel CK, Taubenberger JK, Cox NJ, Gust ID, et al. A global lab against influenza. Science. 2001；293：1729. – reference: 24) Imai K, Ochiai K, Okamoto T. Reactivation of latent HIV-1 infection by the periodontopathic bacterium Porphyromonas gingivalis involves histone modification. J Immunol. 2009；182（6）：3688-95. – reference: 35) Kato A, Imai K, Ochiai K, Ogata Y. Prevalence and quantitative analysis of Epstein - Barr virus DNA and Porphyromonas gingivalis associated with Japanese chronic periodontitis patients. Clin Oral Investig. 2015；19（7）：1605-10. – reference: 16) Yoneyama T, Yoshida M, Matsui T, Sasaki H. Oral care and pneumonia. Lancet. 1999；354：515. – reference: 3) Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019（COVID-19）Outbreak in ChinaSummary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020；323（13）：1239-42. – reference: 10) Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical Course and Risk Factors for Mortality of Adult Inpatients With COVID-19 in Wuhan, China：A Retrospective Cohort Study. Lancet. 2020；395（10229）：1054-62. – reference: 1) Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020；181（2）：271-80. – reference: 27) Morris TL, Arnold RR, Webster-Cyriaque J. Signaling cascades triggered by bacterial metabolic end products during reactivation of Kaposi’s sarcoma-associated herpesvirus. J Virol. 2007；81：6032-42. – reference: 21) Chattin BR, Ishihara K, Okuda K, Hirai Y, Ishikawa T. Specific microbial colonizations in the periodontal sites of HIV-infected subjects. Microbiol. Immunol. 1999；43：847-52. – reference: 7) Akata K, Yatera K, Yamasaki K, Kawanami T, Naito K, Noguchi S, et al. The significance of oral streptococci in patients with pneumonia with risk factors for aspiration：the bacterial floral analysis of 16S ribosomal RNA gene using bronchoalveolar lavage fluid. BMC Pulm Med. 2016；16：79. – reference: 2) Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19：consider cytokine storm syndromes and immunosuppression. Lancet. 2020；395（10229）：1033-34. – reference: 4) Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19：evidence from meta-analysis. Aging. 2020；12（7）：6049-57. – reference: 17) Zhou X, Han J, Liu Z, Song Y, Wang Z, Sun Z. Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis：a 2-year pilot randomized controlled trial. J Clin Periodontol. 2014；41：564-72. – reference: 37) Himi K, Takeichi O, Imai K, Hatori K, Tamura T, Ogiso B. Epstein-Barr virus reactivation by persistent apical periodontal pathogens. Int Endod J. 2020；53（4）：492-505. – reference: 45) Sunde PT, Olsen I, Enersen M, Grinde B. Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy. J Clin Virol. 2008；42：176-78. – reference: 22) Jotwani R, Muthukuru M, Cutler CW. Cutler. Increase in HIV receptors/co-receptors//-defensins in inflamed human gingiva. J. Dent. Res. 2004；83：371-77. – reference: 30) Tashiro M, Ciborowski P, Reinacher M, Pulverer G, Klenk HD, Rott R. Synergistic role of staphylococcal proteases in the induction of influenza virus pathogenicity. Virology. 1987；157：421-30. – reference: 13) Hayata M, Watanabe N, Tamura M, Kamio N, Tanaka H, Nodomi K, et al. The Periodontopathic Bacterium Fusobacterium nucleatum Induced Proinflammatory Cytokine Production by Human Respiratory Epithelial Cell Lines and in the Lower Respiratory Organs in Mice. Cell Physiol Biochem. 2019；53：49-61. – reference: 33) Slots J. Human viruses in periodontitis. Periodontol. 2000；53：89-110. – reference: 26) Das B, Dobrowolski C, Shahir AM, Feng Z, Yu X, Sha J, et al. Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications. Virology. 2015；474：65-81. – reference: 41) Watanabe N, Nodomi K, Koike R, Kato A, Takeichi O, Kotani AI, et al. 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| Snippet | 「はじめに」 医学の進歩の歴史は, 感染症との戦いの歴史と言っても過言ではない. ジェンナーによるワクチンの開発やフレミングによるペニシリンの発見に続き, 多くのワクチンや薬が開発され感染症は制圧されると思われた. しかし, 新型インフルエンザやエボラ出血熱などの新たな感染症の発生やAIDSの蔓延,... |
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| SubjectTerms | COVID-19 HIV/AIDS ウイルス 微生物間相互作用 歯周疾患 歯周病原菌 |
| Title | 「口腔細菌─ウイルス─宿主相互作用」の視点に立った感染症の発症と増悪機序 |
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