NOD蛋白質の機能から考える『自己炎症疾患』発症の分子メカニズム
最近，自然免疫機構に関わる病原体認識受容体に関する研究が急速に進みつつある．特に，細胞膜に存在するToll-like receptor (TLR）が有名であるが，細胞質にも同様の病原体を認識するnucleotide-binding oligomerization-domain protein（NOD）蛋白質とよばれる病原体認識受容体が存在する．NOD蛋白質のひとつであるNod2の変異が，炎症性腸疾患であるクローン病の罹りやすさと関係するという報告後，家族性寒冷蕁麻疹（Familial cold urticaria : FCU)/家族性寒冷自己炎症疾患（Familial cold autoinf...
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| Published in | 日本臨床免疫学会会誌 Vol. 30; no. 2; pp. 68 - 77 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本臨床免疫学会
2007
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| Online Access | Get full text |
| ISSN | 0911-4300 1349-7413 |
| DOI | 10.2177/jsci.30.68 |
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| Abstract | 最近，自然免疫機構に関わる病原体認識受容体に関する研究が急速に進みつつある．特に，細胞膜に存在するToll-like receptor (TLR）が有名であるが，細胞質にも同様の病原体を認識するnucleotide-binding oligomerization-domain protein（NOD）蛋白質とよばれる病原体認識受容体が存在する．NOD蛋白質のひとつであるNod2の変異が，炎症性腸疾患であるクローン病の罹りやすさと関係するという報告後，家族性寒冷蕁麻疹（Familial cold urticaria : FCU)/家族性寒冷自己炎症疾患（Familial cold autoinflammatory syndrome : FCAS), Muckle-Wells syndrome (MWS），新生児発症全身炎症疾患（Neonatal onset multisystem inflammatory disease : NOMID)/慢性乳児期発症神経皮膚関節症候群（Chronic infantile neurologic cutaneous and articular syndrome : CINCA）とNOD蛋白質の一つであるpypaf1/NALP3/cryopyrinの変異など，NOD蛋白質の変異と自己炎症疾患との関連が報告されている．本稿では，これらNOD蛋白質の発見の歴史，NOD蛋白質の機能を概説し，NOD蛋白質の変異がどのようなメカニズムで自己炎症疾患に関わっているのかを解説する． |
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| AbstractList | 最近，自然免疫機構に関わる病原体認識受容体に関する研究が急速に進みつつある．特に，細胞膜に存在するToll-like receptor (TLR）が有名であるが，細胞質にも同様の病原体を認識するnucleotide-binding oligomerization-domain protein（NOD）蛋白質とよばれる病原体認識受容体が存在する．NOD蛋白質のひとつであるNod2の変異が，炎症性腸疾患であるクローン病の罹りやすさと関係するという報告後，家族性寒冷蕁麻疹（Familial cold urticaria : FCU)/家族性寒冷自己炎症疾患（Familial cold autoinflammatory syndrome : FCAS), Muckle-Wells syndrome (MWS），新生児発症全身炎症疾患（Neonatal onset multisystem inflammatory disease : NOMID)/慢性乳児期発症神経皮膚関節症候群（Chronic infantile neurologic cutaneous and articular syndrome : CINCA）とNOD蛋白質の一つであるpypaf1/NALP3/cryopyrinの変異など，NOD蛋白質の変異と自己炎症疾患との関連が報告されている．本稿では，これらNOD蛋白質の発見の歴史，NOD蛋白質の機能を概説し，NOD蛋白質の変異がどのようなメカニズムで自己炎症疾患に関わっているのかを解説する． 「抄録」最近, 自然免疫機構に関わる病原体認識受容体に関する研究が急速に進みつつある. 特に, 細胞膜に存在するToll-like receptor(TLR)が有名であるが, 細胞質にも同様の病原体を認識するnucleotide-binding oligomerization domain protein(NOD)蛋白質とよばれる病原体認識受容体が存在する. NOD蛋白質のひとつであるNod2の変異が, 炎症性腸疾患であるクローン病の罹りやすさと関係するという報告後, 家族性寒冷蕁麻疹(Familial cold urticaria：FCU)/家族性寒冷自己炎症疾患(Familial cold autoinflammatory syndrome：FCAS), Muckle-Wells syndrome(MWS), 新生児発症全身炎症疾患(Neonatal onset multisystem inflammatory disease：NOMID)/慢性乳児期発症神経皮膚関節症候群(Chronic infantile neurologic cutaneous and articular syndrome：CINCA)とNOD蛋白質の一つであるpypaf1/NALP3/cryopyrinの変異など, NOD蛋白質の変異と自己炎症疾患との関連が報告されている. 本稿では, これらNOD蛋白質の発見の歴史, NOD蛋白質の機能を概説し, NOD蛋白質の変異がどのようなメカニズムで自己炎症疾患に関わっているのかを解説する. |
| Author | 猪原, 直弘 長谷川, 瑞穂 増本, 純也 |
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| References | 44) Dowds TA, Masumoto J, Zhu L, Inohara N, Nunez G : Cryopyrin induced IL-1β secretion in monocytic cells : Enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 279 : 21924-21928, 2004. 62) Albrecht M, Lengauer T, Schreiber S. Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence. Bioinformatics 19 : 2171-2175, 2003. 56) Tromp G, Kuivaniemi H, Raphael S, Ala-Kokko L, Christiano A, Considine E, Dhulipala R, Hyland J, Jokinen A, Kivirikko S, Korn R, Madhatheri S, McCarron S, Pulkkinen L, Punnett H, Shimoya K, Spotila L, Tate A, Williams CJ : Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16. Am J Hum Genet 59 : 1097-1107, 1996. 64) Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci U S A 100 : 13501-13506, 2003 9) Manji GA, Wang L, Geddes BJ, Brown M, Merriam S, Al-Garawi A, Mak S, Lora JM, Briskin M, Jurman M, Cao J, DiStefano PS, Bertin J : PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-κB. J Biol Chem 277 : 11570-11575, 2002. 2) Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G : An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275 : 27823-27831, 2000. 27) Staub E, Dahl E, Rosenthal A. : The DAPIN family : a novel domain links apoptotic and interferon response proteins. Trends Biochem Sci 26 : 83-85, 2001. 8) Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G : Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 : 599-603, 2001. 63) Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL : Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell. 11 : 591-604, 2003. 52) Chamaillard M, Philpott D, Girardin SE, Zouali H, Lesage S, Chareyre F, Bui TH, Giovannini M, Zaehringer U, Penard-Lacronique V, Sansonetti PJ, Hugot JP, Thomas G. : Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A 100 : 3455-3460, 2003. 15) Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J. : Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem Biophys Res Commun 284 : 77-82, 2001. 31) Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. : Three-dimensional structure of the apoptosome : implications for assembly, procaspase-9 binding, and activation. Mol Cell 9 : 423-432, 2002. 41) Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Nunez G : Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun : 302 : 575-580, 2003. 45) Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J : NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder. Immunity 20 : 319-325, 2004. 47) Masumoto J, Taniguchi S, Nakayama J, Shiohara M, Hidaka E, Katsuyama T, Murase S, Sagara J. : Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues. J Histochem Cytochem 49 : 1269-1275, 2001. 1) Inohara N, Núñez G : NODs : intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3 : 371-382, 2003. 11) Dode C, Le Du N, Cuisset L, Letourneur F, Berthelot JM, Vaudour G, Meyrier A, Watts RA, Scott DG, Nicholls A, Granel B, Frances C, Garcier F, Edery P, Boulinguez S, Domergues JP, Delpech M, Grateau G : New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria : a novel mutation underlies both syndromes. Am J Hum Genet 70 : 1498-1506, 2002. 16) Tschopp J, Martinon F, Burns K. NALPs : a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4 : 95-104, 2003. 51) Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozoren N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Nunez G. : Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 281 : 35217-35223, 2006 32) Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jehanno M, Viala J, Tedin K, Taha MK, Labigne A, Zahringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ : Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300 : 1584-1587, 2003. 57) Wang X, Kuivaniemi H, Bonavita G, Williams CJ, Tromp G : High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus. BMC Genomics 3 : 24, 2002. 10) Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD : Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29 : 301-305, 2001. 30) Zou H, Li Y, Liu X, Wang X. : An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274 : 11549-11556, 1999. 35) Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ : Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278 : 8869-8872, 2003. 23) Bertin J, DiStefano PS. : The PYRIN domain : a novel motif found in apoptosis and inflammation proteins. Cell Death Differ 7 : 1273-1274, 2000. 49) Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A. : Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 7 : 569-575, 2006. 25) Martinon F, Hofmann K, Tschopp J. : The pyrin domain : a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol 11 : R118-120, 2001. 29) Inohara N, Chamaillard M, McDonald C, Nunez G. : NOD-LRR proteins : role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74 : 355-383, 2005. 59) Kanazawa N, Okafuji I, Kambe N, Nishikomori R, Nakata-Hizume M, Nagai S, Fuji A, Yuasa T, Manki A, Sakurai Y, Nakajima M, Kobayashi H, Fujiwara I, Tsutsumi H, Utani A, Nishigori C, Heike T, Nakahata T, Miyachi Y. : Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation : common genetic etiology with Blau syndrome. Blood 105 : 1195-1197, 2005. 6) Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. : Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J Biol Chem 276 : 4812-4818, 2001. 43) Martinon F, Burns K, Tschopp J : The inflammasome : a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10 : 417-426, 2002. 58) Miceli-Richard C, Lesage S, Rybojad M, Prieur AM, Manouvrier-Hanu S, Hafner R, Chamaillard M, Zouali H, Thomas G, Hugot JP : CARD15 mutations in Blau syndrome. Nat Genet 29 : 19-20, 2001. 55) Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. : Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing. Science 307 : 734-738, 2005. Erratum in : Science 308 : 633, 2005. 19) The French FMF Consortium : A candidate gene for familial Mediterranean fever. Nat Genet 17 : 25-31, 1997. 42) Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES : The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 277 : 21119-21122, 2002. 53) Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N, Núñez G : Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J 23 : 1587-1597 : 2004. 48) Taxman DJ, Zhang J, Champagne C, Bergstralh DT, Iocca HA, Lich JD, Ting JP. : Cutting edge : ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J Immunol 177 : 4252-4256, 2006. 46) Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Nunez G, Inohara N : ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 303 : 69-73, 2003. 61) Ramos E, Arostegui JI, Campuzano S, Rius J, Bousono C, Yague J. : Positive clinical and biochemical responses to anakinra in a 3-yr-old patient with cryopyrin-associated periodic syndrome (CAPS). Rheumatology (Oxford) 44 : 1072-1073, 2005. 39) Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. : Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 : 237-241, 2006. 60) Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nunez G. : Expression of NOD2 in Paneth cells : a possible link to Crohn's ileitis. Gut 52 : 1591-1597, 2003. 12) Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD : Fine structure mapping of CIAS1 : identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet 112 : 209-216, 2003. 3) Zou H, Li Y, Liu X, Wang X : An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274 : 11549-11556, 1999. 21) Hull KM, Shoham N, Chae JJ, Aksentijevich I, Kastner DL : The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations. Curr Opin Rheumatol 15 : 61-69, 2003. 26) Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. : PAAD-a new protein domain associated with apopto |
| References_xml | – reference: 51) Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozoren N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Nunez G. : Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 281 : 35217-35223, 2006 – reference: 46) Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Nunez G, Inohara N : ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 303 : 69-73, 2003. – reference: 65) Hoffman HM, Patel DD : Genomic-based therapy : targeting interleukin-1 for autoinflammatory diseases. Arthritis Rheum 50 : 345-349, 2004. – reference: 14) Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES : Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem 276 : 28309-28313, 2001. – reference: 37) Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. : Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440 : 228-232, 2006. – reference: 52) Chamaillard M, Philpott D, Girardin SE, Zouali H, Lesage S, Chareyre F, Bui TH, Giovannini M, Zaehringer U, Penard-Lacronique V, Sansonetti PJ, Hugot JP, Thomas G. : Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A 100 : 3455-3460, 2003. – reference: 2) Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G : An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275 : 27823-27831, 2000. – reference: 10) Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD : Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29 : 301-305, 2001. – reference: 20) Isomura T, Tamiya-Koizumi K, Suzuki M, Yoshida S, Taniguchi M, Matsuyama M, Ishigaki T, Sakuma S, Takahashi M : RFP is a DNA binding protein associated with the nuclear matrix. Nucleic Acids Res 20 : 5305-5310, 1992. – reference: 43) Martinon F, Burns K, Tschopp J : The inflammasome : a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10 : 417-426, 2002. – reference: 18) The International FMF Consortium : Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90 : 797-807, 1997. – reference: 33) Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Núñez G, Inohara N : An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4 : 702-707, 2003. – reference: 48) Taxman DJ, Zhang J, Champagne C, Bergstralh DT, Iocca HA, Lich JD, Ting JP. : Cutting edge : ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J Immunol 177 : 4252-4256, 2006. – reference: 54) Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, Flavell RA. : Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 : 731-734, 2005. – reference: 29) Inohara N, Chamaillard M, McDonald C, Nunez G. : NOD-LRR proteins : role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74 : 355-383, 2005. – reference: 56) Tromp G, Kuivaniemi H, Raphael S, Ala-Kokko L, Christiano A, Considine E, Dhulipala R, Hyland J, Jokinen A, Kivirikko S, Korn R, Madhatheri S, McCarron S, Pulkkinen L, Punnett H, Shimoya K, Spotila L, Tate A, Williams CJ : Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16. Am J Hum Genet 59 : 1097-1107, 1996. – reference: 6) Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. : Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J Biol Chem 276 : 4812-4818, 2001. – reference: 40) Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, Franchi L, Taraporewala ZF, Miller D, Patton JT, Inohara N, Nunez G. : Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 281 : 36560-36568. 2006. – reference: 60) Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nunez G. : Expression of NOD2 in Paneth cells : a possible link to Crohn's ileitis. Gut 52 : 1591-1597, 2003. – reference: 4) Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G. : Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J Biol Chem 274 : 14560-14567, 1999. – reference: 61) Ramos E, Arostegui JI, Campuzano S, Rius J, Bousono C, Yague J. : Positive clinical and biochemical responses to anakinra in a 3-yr-old patient with cryopyrin-associated periodic syndrome (CAPS). Rheumatology (Oxford) 44 : 1072-1073, 2005. – reference: 34) Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nunez G : Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278 : 5509-5512, 2003. – reference: 26) Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. : PAAD-a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci 26 : 85-87, 2001. – reference: 3) Zou H, Li Y, Liu X, Wang X : An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274 : 11549-11556, 1999. – reference: 44) Dowds TA, Masumoto J, Zhu L, Inohara N, Nunez G : Cryopyrin induced IL-1β secretion in monocytic cells : Enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 279 : 21924-21928, 2004. – reference: 7) Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Núñez G, Cho JH : A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 : 603-606, 2001. – reference: 36) Karin M, Ben-Neriah Y : Phosphorylation meets ubiquitination : the control of NF-κB activity. Annu Rev Immunol 18 : 621-663, 2000. – reference: 45) Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J : NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder. Immunity 20 : 319-325, 2004. – reference: 35) Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ : Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278 : 8869-8872, 2003. – reference: 25) Martinon F, Hofmann K, Tschopp J. : The pyrin domain : a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol 11 : R118-120, 2001. – reference: 58) Miceli-Richard C, Lesage S, Rybojad M, Prieur AM, Manouvrier-Hanu S, Hafner R, Chamaillard M, Zouali H, Thomas G, Hugot JP : CARD15 mutations in Blau syndrome. Nat Genet 29 : 19-20, 2001. – reference: 31) Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. : Three-dimensional structure of the apoptosome : implications for assembly, procaspase-9 binding, and activation. Mol Cell 9 : 423-432, 2002. – reference: 15) Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J. : Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem Biophys Res Commun 284 : 77-82, 2001. – reference: 64) Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci U S A 100 : 13501-13506, 2003 – reference: 55) Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. : Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing. Science 307 : 734-738, 2005. Erratum in : Science 308 : 633, 2005. – reference: 62) Albrecht M, Lengauer T, Schreiber S. Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence. Bioinformatics 19 : 2171-2175, 2003. – reference: 41) Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Nunez G : Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun : 302 : 575-580, 2003. – reference: 19) The French FMF Consortium : A candidate gene for familial Mediterranean fever. Nat Genet 17 : 25-31, 1997. – reference: 50) Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Nunez G. : Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages. Nat Immunol 7 : 576-582, 2006. – reference: 9) Manji GA, Wang L, Geddes BJ, Brown M, Merriam S, Al-Garawi A, Mak S, Lora JM, Briskin M, Jurman M, Cao J, DiStefano PS, Bertin J : PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-κB. J Biol Chem 277 : 11570-11575, 2002. – reference: 16) Tschopp J, Martinon F, Burns K. NALPs : a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4 : 95-104, 2003. – reference: 53) Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N, Núñez G : Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J 23 : 1587-1597 : 2004. – reference: 27) Staub E, Dahl E, Rosenthal A. : The DAPIN family : a novel domain links apoptotic and interferon response proteins. Trends Biochem Sci 26 : 83-85, 2001. – reference: 32) Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jehanno M, Viala J, Tedin K, Taha MK, Labigne A, Zahringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ : Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300 : 1584-1587, 2003. – reference: 38) Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Nunez G. : Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440 : 233-236, 2006. – reference: 39) Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. : Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 : 237-241, 2006. – reference: 42) Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES : The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 277 : 21119-21122, 2002. – reference: 57) Wang X, Kuivaniemi H, Bonavita G, Williams CJ, Tromp G : High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus. BMC Genomics 3 : 24, 2002. – reference: 8) Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G : Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 : 599-603, 2001. – reference: 13) Feldmann J, Prieur AM, Quartier P, Berquin P, Certain S, Cortis E, Teillac-Hamel D, Fischer A, de Saint Basile G : Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet 71 : 198-203, 2002. (Note : Erratum : Am J Hum Genet 71 : 1258, 2002.) – reference: 59) Kanazawa N, Okafuji I, Kambe N, Nishikomori R, Nakata-Hizume M, Nagai S, Fuji A, Yuasa T, Manki A, Sakurai Y, Nakajima M, Kobayashi H, Fujiwara I, Tsutsumi H, Utani A, Nishigori C, Heike T, Nakahata T, Miyachi Y. : Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation : common genetic etiology with Blau syndrome. Blood 105 : 1195-1197, 2005. – reference: 47) Masumoto J, Taniguchi S, Nakayama J, Shiohara M, Hidaka E, Katsuyama T, Murase S, Sagara J. : Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues. J Histochem Cytochem 49 : 1269-1275, 2001. – reference: 12) Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD : Fine structure mapping of CIAS1 : identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet 112 : 209-216, 2003. – reference: 22) Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, Hidaka E, Katsuyama T, Higuchi T, Sagara J : ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 274 : 33835-33838, 1999. – reference: 24) Masumoto J, Taniguchi S, Sagara J. : Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC. Biochem Biophys Res Commun 280 : 652-655, 2001. – reference: 63) Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL : Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell. 11 : 591-604, 2003. – reference: 5) Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS. : Related Articles, Links Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB. J Biol Chem 274 : 12955-12958, 1999. – reference: 1) Inohara N, Núñez G : NODs : intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3 : 371-382, 2003. – reference: 30) Zou H, Li Y, Liu X, Wang X. : An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274 : 11549-11556, 1999. – reference: 23) Bertin J, DiStefano PS. : The PYRIN domain : a novel motif found in apoptosis and inflammation proteins. Cell Death Differ 7 : 1273-1274, 2000. – reference: 11) Dode C, Le Du N, Cuisset L, Letourneur F, Berthelot JM, Vaudour G, Meyrier A, Watts RA, Scott DG, Nicholls A, Granel B, Frances C, Garcier F, Edery P, Boulinguez S, Domergues JP, Delpech M, Grateau G : New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria : a novel mutation underlies both syndromes. Am J Hum Genet 70 : 1498-1506, 2002. – reference: 28) Fairbrother WJ, Gordon NC, Humke EW, O'Rourke KM, Starovasnik MA, Yin JP, Dixit VM. : The PYRIN domain : a member of the death domain-fold superfamily. Protein Sci 10 : 1911-1918, 2001. – reference: 17) Grenier JM, Wang L, Manji GA, Huang WJ, Al-Garawi A, Kelly R, Carlson A, Merriam S, Lora JM, Briskin M, DiStefano PS, Bertin J. : Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1. FEBS Lett 530 : 73-78, 2002. – reference: 49) Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A. : Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 7 : 569-575, 2006. – reference: 21) Hull KM, Shoham N, Chae JJ, Aksentijevich I, Kastner DL : The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations. Curr Opin Rheumatol 15 : 61-69, 2003. |
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| Snippet | 最近，自然免疫機構に関わる病原体認識受容体に関する研究が急速に進みつつある．特に，細胞膜に存在するToll-like receptor (TLR）が有名であるが，細胞質にも同様の病原体を認識するnucleotide-binding oligomerization-domain... 「抄録」最近, 自然免疫機構に関わる病原体認識受容体に関する研究が急速に進みつつある. 特に, 細胞膜に存在するToll-like receptor(TLR)が有名であるが, 細胞質にも同様の病原体を認識するnucleotide-binding oligomerization domain... |
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| Title | NOD蛋白質の機能から考える『自己炎症疾患』発症の分子メカニズム |
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