Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection

• Published in: The international journal of biochemistry & cell biology Vol. 44; no. 9; pp. 1574 - 1584
• Main Authors: Rana, Sanyukta, Yue, Shijing, Stadel, Daniela, Zöller, Margot
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.2012
• Subjects: Animals; Cell Line, Tumor; complementary DNA; drugs; endothelial cells; exosomes; Exosomes - metabolism; Gene Expression Regulation; hematopoietic stem cells; integrins; ligands; lymph nodes; messenger RNA; microRNA; pancreas; prediction; Protein Transport; Rats; Tetraspanins - metabolism; therapeutics

Exosomes are discussed as potent therapeutics due to efficient transfer of proteins, mRNA and miRNA in selective targets. However, therapeutic exosome application requires knowledge on target structures to avoid undue delivery. Previous work suggesting exosomal tetraspanin-integrin complexes to be i...