医科歯科連携の観点から前糖尿病と歯周病の関連性を考える
「1. 前糖尿病(pre-diabetes)とは」糖尿病は, インスリン作用不足による慢性の高血糖状態を主な特徴とする代謝性疾患である. 糖尿病は原因因子の違いにより, 1型と2型に分類される. 1型糖尿病は, インスリンを合成・分泌する膵臓のランゲルハンス島β細胞の破壊や消失がインスリン作用不足の主な原因である. 2型糖尿病は, インスリン分泌低下やインスリン抵抗性をきたす疾患であり, 遺伝因子に過食, 運動不足, 肥満, ストレスなどの環境因子および加齢が影響し発症する. 前糖尿病(pre-diabetes)とは, 血糖値が正常値よりは高いものの, 糖尿病と診断されるほどではない状態を表す...
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| Published in | 日本歯周病学会会誌 Vol. 60; no. 2; pp. 64 - 69 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯周病学会
29.06.2018
日本歯周病学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.60.64 |
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| Abstract | 「1. 前糖尿病(pre-diabetes)とは」糖尿病は, インスリン作用不足による慢性の高血糖状態を主な特徴とする代謝性疾患である. 糖尿病は原因因子の違いにより, 1型と2型に分類される. 1型糖尿病は, インスリンを合成・分泌する膵臓のランゲルハンス島β細胞の破壊や消失がインスリン作用不足の主な原因である. 2型糖尿病は, インスリン分泌低下やインスリン抵抗性をきたす疾患であり, 遺伝因子に過食, 運動不足, 肥満, ストレスなどの環境因子および加齢が影響し発症する. 前糖尿病(pre-diabetes)とは, 血糖値が正常値よりは高いものの, 糖尿病と診断されるほどではない状態を表す. 当初, 米国糖尿病学会(ADA)のガイドラインでは, 空腹時血糖値が100 - 125mg/dlまたは経口ブドウ糖付加試験2時間後血糖値が140 - 199mg/dlと定義されていた. |
|---|---|
| AbstractList | 「1. 前糖尿病(pre-diabetes)とは」糖尿病は, インスリン作用不足による慢性の高血糖状態を主な特徴とする代謝性疾患である. 糖尿病は原因因子の違いにより, 1型と2型に分類される. 1型糖尿病は, インスリンを合成・分泌する膵臓のランゲルハンス島β細胞の破壊や消失がインスリン作用不足の主な原因である. 2型糖尿病は, インスリン分泌低下やインスリン抵抗性をきたす疾患であり, 遺伝因子に過食, 運動不足, 肥満, ストレスなどの環境因子および加齢が影響し発症する. 前糖尿病(pre-diabetes)とは, 血糖値が正常値よりは高いものの, 糖尿病と診断されるほどではない状態を表す. 当初, 米国糖尿病学会(ADA)のガイドラインでは, 空腹時血糖値が100 - 125mg/dlまたは経口ブドウ糖付加試験2時間後血糖値が140 - 199mg/dlと定義されていた. |
| Author | 加藤, 浩一 青山, 典生 三辺, 正人 髙瀬, 雅大 |
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| DOI | 10.2329/perio.60.64 |
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| References | 7) Zuk A, Quiñonez C, Lebenbaum M, Rosella LC: The association between undiagnosed glycaemic abnormalities and cardiometabolic risk factors with periodontitis: results from 2007-2009 Canadian Health Measures Survey. J Clin Periodontol, 44: 132-141, 2017. 24) 糖尿病情報センター, 糖尿病受診中断対策マニュアル. http://dmic.ncgm.go.jp/medical/050/inflrenza_04.html (参照 2014). 16) Demmer RT, Breskin A, Rosenbaum M, Zuk A, LeDuc C, Leibel R, Paster B, Desvarieux M, Jacobs DR Jr, Papapanou PN: The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study. J Clin Periodontol, 44: 255-265, 2017. 13) Javed F, Thafeed Alghamdi AS, Mikami T, Mehmood A, Ahmed HB, Samaranayake LP, Tenenbaum HC: Effect of glycemic control on self-perceived oral health, periodontal parameters, and alveolar bone loss among patients with prediabetes. J Periodontol, 85: 234-241, 2014. 18) Ganesan SM, Joshi V, Fellows M, Dabdoub SM, Nagaraja HN, O'Donnell B, Deshpande NR, Kumar PS: A tale of two risks: smoking, diabetes and the subgingival microbiome. ISME J, 11: 2075-2089, 2017. 20) Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K: Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway. Biochim Biophys Acta, 1832: 2035-2043, 2013. 10) Joseph R, Sasikumar M, Mammen J, Joseraj MG, Radhakrishnan C: Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis. World J Diabetes, 15: 213-221, 2017. 9) Chiu SY, Lai H, Yen AM, Fann JC, Chen LS, Chen HH: Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease: a community-based study of 5,885 Taiwanese aged 35-44 years (KCIS No. 32). Acta Diabetol, 52: 123-131, 2015. 22) Choi YH, McKeown RE, Mayer-Davis EJ, Liese AD, Song KB, Merchant AT: Serum C-reactive protein and immunoglobulin G antibodies to periodontal pathogens may be effect modifiers of periodontitis and hyperglycemia. J Periodontol, 85: 1172-1181, 2014. 17) Hung SL, Lee NG, Chang LY, Chen YT, Lai YL: Stimulatory effects of glucose and Porphyromonas gingivalis lipopolysaccharide on the secretion of inflammatory mediators from human macrophages. J Periodontol, 85: 140-149, 2014. 31) Lalla E, Cheng B, Kunzel C, Burkett S, Ferraro A, Lamster IB: Six-month outcomes in dental patients identified with hyperglycaemia: a randomized clinical trial. J Clin Periodontol, 42: 228-235, 2015. 6) Abduljabbar T, Al-Sahaly F, Al-Kathami M, Afzal S, Vohra F: Comparison of periodontal and peri-implant inflammatory parameters among patients with prediabetes, type 2 diabetes mellitus and non-diabetic controls. Acta Odontol Scand, 75: 319-324, 2017. 11) Alshehri FA, Javed F: Impact of scaling and root planing on clinical periodontal status and glycemic levels in prediabetic patients. Interv Med Appl Sci, 7: 17-21, 2015. 4) Pérez CM, Muñoz F, Andriankaja OM, Ritchie CS, Martínez S, Vergara J, Vivaldi J, López L, Campos M, Joshipura KJ: Cross-sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis. J Clin Periodontol, 44: 142-149, 2017. 12) Simpson TC, Weldon JC, Worthington HV, Needleman I, Wild SH, Moles DR, Stevenson B, Furness S, Iheozor-Ejiofor Z: Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev, 6: CD004714, 2015. 32) 富永一道, 濱野 強, 土﨑しのぶ, 安藤雄一: メタボリックシンドロームに関連する食事・咀嚼・その他の歯科関連要因に関する検討. 口腔衛生会誌, 66: 389-398, 2016. 29) Ziukaite L, Slot DE, Van der Weijden FA: Prevalence of Diabetes Mellitus in People Clinically Diagnosed with Periodontitis: A Systematic Review and Meta-analysis of Epidemiologic Studies. J Clin Periodontol, 10. doi: 10.1111, 2017. 3) Demmer RT, Jacobs DR Jr, Singh R, Zuk A, Rosenbaum M, Papapanou PN, Desvarieux M: Periodontal bacteria and prediabetes prevalence in ORIGINS: The oral infections, glucose intolerance, and insulin resistance study. J Dent Res, 94: 201-211, 2015. 5) Javed F, Al-Kheraif AA, Al Amri MD, Alshehri M, Vohra F, Al-Askar M, Malmstrom H, Romanos GE: Periodontal status and whole salivary cytokine profile among smokers and never-smokers with and without prediabetes. J Periodontol, 86: 890-898, 2015. 28) Teeuw WJ, Kosho MX, Poland DC, Gerdes VE, Loos BG: Periodontitis as a possible early sign of diabetes mellitus. BMJ Open Diabetes Res Care, 5: e000326, 2017. 30) Uehara A, Kurotani K, Kochi T, Kuwahara K, Eguchi M, Imai T, Nishihara A, Tomita K, Yamamoto M, Kuroda R, Nagata T, Omoto D, Murakami T, Shimizu C, Shimizu M, Miyamoto T, Nagahama S, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Sasaki N, Nanri A, Pham NM, Kabe I, Mizoue T, Kunugita N, Dohi S; Japan Epidemiology Collaboration of Occupational Health Study Group: Prevalence of diabetes and pre-diabetes among workers: Japan Epidemiology Collaboration on Occupational Health Study. Diabetes Res Clin Pract, 106: 118-127, 2014. 25) Jontell M, Glick M: Oral health care professionals' identification of cardiovascular disease risk among patients in private dental offices in Sweden. J Am Dent Assoc, 140: 1385-1391, 2009. 8) Kowall B, Holtfreter B, Völzke H, Schipf S, Mundt T, Rathmann W, Kocher T: Pre-diabetes and well-controlled diabetes are not associated with periodontal disease: the SHIP Trend Study. J Clin Periodontol, 42: 422-430, 2015. 27) Herman WH, Taylor GW, Jacobson JJ, Burke R, Brown MB: Screening for prediabetes and type 2 diabetes in dental offices. J Public Health Dent, 75: 175-182, 2015. 14) 日本歯周病学会: 歯周病と全身の健康, 医歯薬出版, 東京, 2016, 88-91. 2) American Diabetes Association: Standards of medical care in diabetes--2010. Diabetes Care, 33: 11-61, 2010. 1) 一般社団法人日本糖尿病学会: 糖尿病治療ガイド2016-2017, 株式会社文光堂, 東京, 2016, 8. 21) Bhat UG, Ilievski V, Unterman TG, Watanabe K: Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic β cell line MIN6. J Periodontol, 85: 1629-1636, 2014. 26) Holm NC, Belstrøm D, Østergaard JA, Schou S, Holmstrup P, Grauballe MB: Identification of individuals with undiagnosed diabetes and pre-diabetes in a Danish cohort attending dental treatment. J Periodontol, 87: 395-402, 2016. 23) 中医協提言, 口腔疾患の重症化予防について. https://www.jda.or.jp/dental_deta/pdf/chapter=01.pdf (参照 2016). 15) 日本歯周病学会: 糖尿病患者に対する歯周治療ガイドライン, 改訂第2版, 医歯薬出版, 東京, 2015, 29-54. 19) Huang Y, Guo W, Zeng J, Chen G, Sun W, Zhang X, Tian W: Prediabetes enhances periodontal inflammation consistent with activation of Toll-like receptor-mediated nuclear factor-κB pathway in rats. J Periodontol, 87: 64-74, 2016. |
| References_xml | – reference: 14) 日本歯周病学会: 歯周病と全身の健康, 医歯薬出版, 東京, 2016, 88-91. – reference: 19) Huang Y, Guo W, Zeng J, Chen G, Sun W, Zhang X, Tian W: Prediabetes enhances periodontal inflammation consistent with activation of Toll-like receptor-mediated nuclear factor-κB pathway in rats. J Periodontol, 87: 64-74, 2016. – reference: 1) 一般社団法人日本糖尿病学会: 糖尿病治療ガイド2016-2017, 株式会社文光堂, 東京, 2016, 8. – reference: 25) Jontell M, Glick M: Oral health care professionals' identification of cardiovascular disease risk among patients in private dental offices in Sweden. J Am Dent Assoc, 140: 1385-1391, 2009. – reference: 21) Bhat UG, Ilievski V, Unterman TG, Watanabe K: Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic β cell line MIN6. J Periodontol, 85: 1629-1636, 2014. – reference: 29) Ziukaite L, Slot DE, Van der Weijden FA: Prevalence of Diabetes Mellitus in People Clinically Diagnosed with Periodontitis: A Systematic Review and Meta-analysis of Epidemiologic Studies. J Clin Periodontol, 10. doi: 10.1111, 2017. – reference: 20) Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K: Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway. Biochim Biophys Acta, 1832: 2035-2043, 2013. – reference: 27) Herman WH, Taylor GW, Jacobson JJ, Burke R, Brown MB: Screening for prediabetes and type 2 diabetes in dental offices. J Public Health Dent, 75: 175-182, 2015. – reference: 8) Kowall B, Holtfreter B, Völzke H, Schipf S, Mundt T, Rathmann W, Kocher T: Pre-diabetes and well-controlled diabetes are not associated with periodontal disease: the SHIP Trend Study. J Clin Periodontol, 42: 422-430, 2015. – reference: 13) Javed F, Thafeed Alghamdi AS, Mikami T, Mehmood A, Ahmed HB, Samaranayake LP, Tenenbaum HC: Effect of glycemic control on self-perceived oral health, periodontal parameters, and alveolar bone loss among patients with prediabetes. J Periodontol, 85: 234-241, 2014. – reference: 3) Demmer RT, Jacobs DR Jr, Singh R, Zuk A, Rosenbaum M, Papapanou PN, Desvarieux M: Periodontal bacteria and prediabetes prevalence in ORIGINS: The oral infections, glucose intolerance, and insulin resistance study. J Dent Res, 94: 201-211, 2015. – reference: 5) Javed F, Al-Kheraif AA, Al Amri MD, Alshehri M, Vohra F, Al-Askar M, Malmstrom H, Romanos GE: Periodontal status and whole salivary cytokine profile among smokers and never-smokers with and without prediabetes. J Periodontol, 86: 890-898, 2015. – reference: 11) Alshehri FA, Javed F: Impact of scaling and root planing on clinical periodontal status and glycemic levels in prediabetic patients. Interv Med Appl Sci, 7: 17-21, 2015. – reference: 12) Simpson TC, Weldon JC, Worthington HV, Needleman I, Wild SH, Moles DR, Stevenson B, Furness S, Iheozor-Ejiofor Z: Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev, 6: CD004714, 2015. – reference: 26) Holm NC, Belstrøm D, Østergaard JA, Schou S, Holmstrup P, Grauballe MB: Identification of individuals with undiagnosed diabetes and pre-diabetes in a Danish cohort attending dental treatment. J Periodontol, 87: 395-402, 2016. – reference: 6) Abduljabbar T, Al-Sahaly F, Al-Kathami M, Afzal S, Vohra F: Comparison of periodontal and peri-implant inflammatory parameters among patients with prediabetes, type 2 diabetes mellitus and non-diabetic controls. Acta Odontol Scand, 75: 319-324, 2017. – reference: 22) Choi YH, McKeown RE, Mayer-Davis EJ, Liese AD, Song KB, Merchant AT: Serum C-reactive protein and immunoglobulin G antibodies to periodontal pathogens may be effect modifiers of periodontitis and hyperglycemia. J Periodontol, 85: 1172-1181, 2014. – reference: 2) American Diabetes Association: Standards of medical care in diabetes--2010. Diabetes Care, 33: 11-61, 2010. – reference: 30) Uehara A, Kurotani K, Kochi T, Kuwahara K, Eguchi M, Imai T, Nishihara A, Tomita K, Yamamoto M, Kuroda R, Nagata T, Omoto D, Murakami T, Shimizu C, Shimizu M, Miyamoto T, Nagahama S, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Sasaki N, Nanri A, Pham NM, Kabe I, Mizoue T, Kunugita N, Dohi S; Japan Epidemiology Collaboration of Occupational Health Study Group: Prevalence of diabetes and pre-diabetes among workers: Japan Epidemiology Collaboration on Occupational Health Study. Diabetes Res Clin Pract, 106: 118-127, 2014. – reference: 32) 富永一道, 濱野 強, 土﨑しのぶ, 安藤雄一: メタボリックシンドロームに関連する食事・咀嚼・その他の歯科関連要因に関する検討. 口腔衛生会誌, 66: 389-398, 2016. – reference: 24) 糖尿病情報センター, 糖尿病受診中断対策マニュアル. http://dmic.ncgm.go.jp/medical/050/inflrenza_04.html (参照 2014). – reference: 7) Zuk A, Quiñonez C, Lebenbaum M, Rosella LC: The association between undiagnosed glycaemic abnormalities and cardiometabolic risk factors with periodontitis: results from 2007-2009 Canadian Health Measures Survey. J Clin Periodontol, 44: 132-141, 2017. – reference: 28) Teeuw WJ, Kosho MX, Poland DC, Gerdes VE, Loos BG: Periodontitis as a possible early sign of diabetes mellitus. BMJ Open Diabetes Res Care, 5: e000326, 2017. – reference: 23) 中医協提言, 口腔疾患の重症化予防について. https://www.jda.or.jp/dental_deta/pdf/chapter=01.pdf (参照 2016). – reference: 15) 日本歯周病学会: 糖尿病患者に対する歯周治療ガイドライン, 改訂第2版, 医歯薬出版, 東京, 2015, 29-54. – reference: 9) Chiu SY, Lai H, Yen AM, Fann JC, Chen LS, Chen HH: Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease: a community-based study of 5,885 Taiwanese aged 35-44 years (KCIS No. 32). Acta Diabetol, 52: 123-131, 2015. – reference: 10) Joseph R, Sasikumar M, Mammen J, Joseraj MG, Radhakrishnan C: Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis. World J Diabetes, 15: 213-221, 2017. – reference: 18) Ganesan SM, Joshi V, Fellows M, Dabdoub SM, Nagaraja HN, O'Donnell B, Deshpande NR, Kumar PS: A tale of two risks: smoking, diabetes and the subgingival microbiome. ISME J, 11: 2075-2089, 2017. – reference: 17) Hung SL, Lee NG, Chang LY, Chen YT, Lai YL: Stimulatory effects of glucose and Porphyromonas gingivalis lipopolysaccharide on the secretion of inflammatory mediators from human macrophages. J Periodontol, 85: 140-149, 2014. – reference: 16) Demmer RT, Breskin A, Rosenbaum M, Zuk A, LeDuc C, Leibel R, Paster B, Desvarieux M, Jacobs DR Jr, Papapanou PN: The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study. J Clin Periodontol, 44: 255-265, 2017. – reference: 31) Lalla E, Cheng B, Kunzel C, Burkett S, Ferraro A, Lamster IB: Six-month outcomes in dental patients identified with hyperglycaemia: a randomized clinical trial. J Clin Periodontol, 42: 228-235, 2015. – reference: 4) Pérez CM, Muñoz F, Andriankaja OM, Ritchie CS, Martínez S, Vergara J, Vivaldi J, López L, Campos M, Joshipura KJ: Cross-sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis. J Clin Periodontol, 44: 142-149, 2017. |
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| Title | 医科歯科連携の観点から前糖尿病と歯周病の関連性を考える |
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| ispartofPNX | 日本歯周病学会会誌, 2018/06/29, Vol.60(2), pp.64-69 |
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