Immunomodulatory effects of Lactobacillus biogenic administration in dogs

[Abstract] Lactobacillus biogenics were administered to four dogs for 56 days. The regulatory T cell (Treg) count was found to be increased in all four dogs on 56 days. On day 112, 56 days after completion of Lactobacillus probiotic administration, the percentage of Tregs was found to be decreased i...

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Published inThe Japanese Journal of Veterinary Research Vol. 69; no. 3; pp. 175 - 182
Main Authors Junro Hayasaka, Yuka Nunomura, Miki Omura, Yukie Katayama, Tomoko Yokota, Nanako Osawa, Shinji Makino, Tetsuya Mizutani, Tsuyoshi Uchide, Yoshiteru Murata
Format Journal Article
LanguageEnglish
Published Faculty of Veterinary Medicine, Hokkaido University 01.08.2021
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Abstract [Abstract] Lactobacillus biogenics were administered to four dogs for 56 days. The regulatory T cell (Treg) count was found to be increased in all four dogs on 56 days. On day 112, 56 days after completion of Lactobacillus probiotic administration, the percentage of Tregs was found to be decreased in three dogs. Plasma IgA levels tended to increase after stopping Lactobacillus administration. Metagenomic analysis of bacterial flora found in dog feces revealed that Firmicutes, Proteobacteria, Bacteroidetes, and Fusobacteria were predominantly found in all 4 dogs. Analysis of fecal microbiomes of species level on day 56 showed that 99 % members of genus Prevotella belonged to species copri. This study demonstrates some of the immunomodulatory effects of Lactobacillus probiotics on dogs.
AbstractList [Abstract] Lactobacillus biogenics were administered to four dogs for 56 days. The regulatory T cell (Treg) count was found to be increased in all four dogs on 56 days. On day 112, 56 days after completion of Lactobacillus probiotic administration, the percentage of Tregs was found to be decreased in three dogs. Plasma IgA levels tended to increase after stopping Lactobacillus administration. Metagenomic analysis of bacterial flora found in dog feces revealed that Firmicutes, Proteobacteria, Bacteroidetes, and Fusobacteria were predominantly found in all 4 dogs. Analysis of fecal microbiomes of species level on day 56 showed that 99 % members of genus Prevotella belonged to species copri. This study demonstrates some of the immunomodulatory effects of Lactobacillus probiotics on dogs.
Author Tetsuya Mizutani
Yoshiteru Murata
Nanako Osawa
Yuka Nunomura
Shinji Makino
Tsuyoshi Uchide
Tomoko Yokota
Miki Omura
Yukie Katayama
Junro Hayasaka
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CorporateAuthor Mizuhodai Animal Hospital
Center for Infectious Diseases Epidemiology and Prevention Research
Gifu University
Department of Microbiology and Immunology
Tokyo University of Agriculture and Technology
The United Graduate School of Veterinary Sciences
Faculty of Agriculture
Murata Animal Hospital
Department of Veterinary Surgery
The University of Texas Medical Branch at Galveston
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– name: Tokyo University of Agriculture and Technology
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DOI 10.14943/jjvr.69.3.175
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Snippet [Abstract] Lactobacillus biogenics were administered to four dogs for 56 days. The regulatory T cell (Treg) count was found to be increased in all four dogs on...
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