Strategies for Genome Reduction in Microbial Genomes

Niche dependent differential gene loss and overlapping genes have been proposed as means of achieving genome reduction by retaining indispensable genes and compressing maximum amount of information in available sequence space. Herein, we analyzed the differential gene loss and overlapping genes in b...

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Bibliographic Details
Published inGenome Informatics Vol. 16; no. 2; pp. 69 - 75
Main Authors Sakharkar, Kishore R., Chow, Vincent T.K.
Format Journal Article
LanguageEnglish
Published Japan Japanese Society for Bioinformatics 2005
Subjects
Bacteria - genetics
Computational Biology - methods
Evolution, Molecular
Gene Deletion
Genes, Overlapping
genome reduction
Genome, Bacterial
minimal genomes
obligatory intracellular parasites
overlapping genes
overprinting
Structural Homology, Protein
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Summary:Niche dependent differential gene loss and overlapping genes have been proposed as means of achieving genome reduction by retaining indispensable genes and compressing maximum amount of information in available sequence space. Herein, we analyzed the differential gene loss and overlapping genes in bacterial genomes with different lifestyles. Our results clearly suggest that gene loss and overlapping genes could be a result of evolutionary pressure to minimize genome size. Comparative analysis of the genomes shows that the genomes display marked similarities in patterns of protein length and frequency. It is clear from our analysis that habitat is a major factor contributing to genome reduction. These comparisons increase our knowledge of the forces that drive the extreme specialization of the bacteria and its association to the host.
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ISSN:0919-9454
2185-842X
DOI:10.11234/gi1990.16.2_69