レストレスレッグス症候群の症状拡大と頻度増加がパーキンソン病の早期徴候と考えられた女性例

症例は57歳女性．33年間左半身の異常感覚による不眠があった．初診の前年から頻度が増加し，右下肢にも症状が出現するようになった．娘は20歳からレストレスレッグス症候群（restless legs syndrome; RLS）がある．神経学的所見に異常はなかった．血液検査では腎機能は正常で鉄欠乏や貧血はなかった．RLSと診断しプラミペキソール低用量にて良好な治療効果が得られていた．初診から1年後に右肩痛が出現し，その半年後に，右手の振戦が出現した．臨床症状，ドパミントランスポータースキャンおよび123I-MIBG心筋シンチグラフィー検査結果からパーキンソン病（Parkinson’s diseas...

Full description

Saved in:
Bibliographic Details
Published in臨床神経学 Vol. 58; no. 10; pp. 617 - 621
Main Authors 藤田, 裕明, 平田, 幸一, 鈴木, 圭輔, 中村, 利生, 宮本, 雅之, 松原, 健朗
Format Journal Article
LanguageJapanese
Published 日本神経学会 2018
Subjects
RLS家族歴
RLS症状拡大
パーキンソン病
レストレスレッグス症候群
Online AccessGet full text
ISSN0009-918X
1882-0654
DOI10.5692/clinicalneurol.cn-001176

Cover

Abstract 症例は57歳女性．33年間左半身の異常感覚による不眠があった．初診の前年から頻度が増加し，右下肢にも症状が出現するようになった．娘は20歳からレストレスレッグス症候群（restless legs syndrome; RLS）がある．神経学的所見に異常はなかった．血液検査では腎機能は正常で鉄欠乏や貧血はなかった．RLSと診断しプラミペキソール低用量にて良好な治療効果が得られていた．初診から1年後に右肩痛が出現し，その半年後に，右手の振戦が出現した．臨床症状，ドパミントランスポータースキャンおよび123I-MIBG心筋シンチグラフィー検査結果からパーキンソン病（Parkinson’s disease; PD）と診断した．RLS症状の拡大や頻度増加時にはPDの早期徴候の可能性を考慮する必要がある．
AbstractList 症例は57歳女性．33年間左半身の異常感覚による不眠があった．初診の前年から頻度が増加し，右下肢にも症状が出現するようになった．娘は20歳からレストレスレッグス症候群（restless legs syndrome; RLS）がある．神経学的所見に異常はなかった．血液検査では腎機能は正常で鉄欠乏や貧血はなかった．RLSと診断しプラミペキソール低用量にて良好な治療効果が得られていた．初診から1年後に右肩痛が出現し，その半年後に，右手の振戦が出現した．臨床症状，ドパミントランスポータースキャンおよび123I-MIBG心筋シンチグラフィー検査結果からパーキンソン病（Parkinson’s disease; PD）と診断した．RLS症状の拡大や頻度増加時にはPDの早期徴候の可能性を考慮する必要がある．
Author 鈴木, 圭輔
藤田, 裕明
平田, 幸一
宮本, 雅之
中村, 利生
松原, 健朗
Author_xml – sequence: 1
  fullname: 藤田, 裕明
  organization: 獨協医科大学内科学（神経）
– sequence: 1
  fullname: 平田, 幸一
  organization: 獨協医科大学内科学（神経）
– sequence: 1
  fullname: 鈴木, 圭輔
  organization: 獨協医科大学内科学（神経）
– sequence: 1
  fullname: 中村, 利生
  organization: リハビリテーション天草病院脳神経内科
– sequence: 1
  fullname: 宮本, 雅之
  organization: 獨協医科大学看護学部看護医科学（病態治療）
– sequence: 1
  fullname: 松原, 健朗
  organization: 獨協医科大学内科学（神経）
BookMark eNpVkM1Kw0AUhQdRsNa-gy-QOpNkkslSxD8odKPgLkzHRFNilLQu3DWJYm27cVUEoVX8BRWhIvjXl7mm1bcwpYq4Ofe7cM_hcibQqLflWQhNEZylmiFPC9fxHMFdz9rxt9ys8CSMCdG1EZQijMkS1qg6ilIYY0MyCFsdR5lSySkMdmowoqbQHkS3ED5DVP2FW4giCB8S7jcP4spxv3sOwX3C_dpTr34an19BcP3Vfo1fLuOzZlxrQ9CA6AiiNwjvIOpA-J5ov7mfuHrNm95JK-4-JjmJ67MSQVCF8BDCBgSt-KLTq1x9dOuTaMzmbsnK_Mw0WpmfW55dlHL5haXZmZxUVDBlklBlqhvc4snzpEA1SjVb12VdcMOWbWxRFctYV5gtY40xoghZNdYop3pBCKGqa0oa5Ye5xVKZr1vmtu9scn_X5H7ZEa5l_q_TpMwkeKDCM4e9_l1ucN8scuUbuOGmyA
ContentType Journal Article
Copyright 2018 日本神経学会
Copyright_xml – notice: 2018 日本神経学会
DOI 10.5692/clinicalneurol.cn-001176
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1882-0654
EndPage 621
ExternalDocumentID article_clinicalneurol_58_10_58_cn_001176_article_char_ja
GroupedDBID ALMA_UNASSIGNED_HOLDINGS
JSF
OK1
P2P
RJT
ID FETCH-LOGICAL-j3058-c42579aea9591b56556f7727ca9f2f0e54020738f2068813c249d5a57bccc44d3
ISSN 0009-918X
IngestDate Wed Sep 03 06:23:56 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language Japanese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-j3058-c42579aea9591b56556f7727ca9f2f0e54020738f2068813c249d5a57bccc44d3
OpenAccessLink https://www.jstage.jst.go.jp/article/clinicalneurol/58/10/58_cn-001176/_article/-char/ja
PageCount 5
ParticipantIDs jstage_primary_article_clinicalneurol_58_10_58_cn_001176_article_char_ja
PublicationCentury 2000
PublicationDate 20180000
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – year: 2018
  text: 20180000
PublicationDecade 2010
PublicationTitle 臨床神経学
PublicationTitleAlternate 臨床神経学
PublicationYear 2018
Publisher 日本神経学会
Publisher_xml – name: 日本神経学会
References 8) Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002;59:421-424.
19) Gupta A, Shukla G, Mohammed A, et al. Restless legs syndrome, a predictor of subcortical stroke: a prospective study in 346 stroke patients. Sleep Med 2017;29:61-67.
27) Okamura M, Suzuki K, Matsubara T, et al. Restlessness restricted to the perianal region in a patient with Parkinson’s disease. Parkinsonism Relat Disord 2018;51:117-118.
17) Wong JC, Li Y, Schwarzschild MA, et al. Restless legs syndrome: an early clinical feature of Parkinson disease in men. Sleep 2014;37:369-372.
4) Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med 2014;15:860-873.
13) Adel S, Djarmati A, Kabakci K, et al. Co-occurrence of restless legs syndrome and Parkin mutations in two families. Mov Disord 2006;21:258-263.
6) Takegami M, Suzukamo Y, Wakita T, et al. Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on item response theory. Sleep Med 2009;10:556-565.
18) Karroum EG, Leu-Semenescu S, Arnulf I. Topography of the sensations in primary restless legs syndrome. J Neurol Sci 2012;320:26-31.
22) Kwon DY, Seo WK, Yoon HK, et al. Transcranial brain sonography in Parkinson’s disease with restless legs syndrome. Mov Disord 2010;25:1373-1378.
14) Young JE, Vilarino-Guell C, Lin SC, et al. Clinical and genetic description of a family with a high prevalence of autosomal dominant restless legs syndrome. Mayo Clin Proc 2009;84:134-138.
3) Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology 2011;77:1941-1946.
9) Nomura T, Inoue Y, Miyake M, et al. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson’s disease. Mov Disord 2006;21:380-384.
20) Earley CJ, Allen RP, Connor JR, et al. The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal. Sleep Med 2009;10:1155-1157.
1) Möller JC, Unger M, Stiasny-Kolster K, et al. Restless Legs Syndrome (RLS) and Parkinson’s disease (PD)-related disorders or different entities? J Neurol Sci 2010;289:135-137.
7) Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 2015;30:1591-1601.
10) Peralta CM, Frauscher B, Seppi K, et al. Restless legs syndrome in Parkinson’s disease. Mov Disord 2009;24:2076-2080.
25) 澤村正典，當間圭一郎，垂髪祐樹ら．陰部むずむず感で発症したパーキンソン病の1例．臨床神経 2015;55:266-268.
15) Dragan EM, Chen Z, Ondo WG. Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson’s disease: a pilot study. Int J Neurosci 2015;125:526-530.
5) Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121-132.
21) Garcia-Borreguero D, Cano-Pumarega I. New concepts in the management of restless legs syndrome. BMJ 2017;356:j104.
16) Moccia M, Erro R, Picillo M, et al. A Four-year longitudinal study on restless legs syndrome in Parkinson disease. Sleep 2016;39:405-412.
24) Suzuki K, Miyamoto M, Miyamoto T, et al. Restless “lower back” in a patient with Parkinson’s disease. Tremor Other Hyperkinet Mov (N Y) 2013;3.
11) Gan-Or Z, Alcalay RN, Rouleau GA, et al. Sleep disorders and Parkinson disease; lessons from genetics. Sleep Med Rev 2018.
23) Turrini A, Raggi A, Calandra-Buonaura G, et al. Not only limbs in atypical restless legs syndrome. Sleep Med Rev 2018;38:50-55.
26) Aquino CC, Mestre T, Lang AE. Restless genital syndrome in Parkinson disease. JAMA Neurol 2014;71:1559-1561.
12) Puschmann A, Pfeiffer RF, Stoessl AJ, et al. A family with Parkinsonism, essential tremor, restless legs syndrome, and depression. Neurology 2011;76:1623-1630.
2) Angelini M, Negrotti A, Marchesi E, et al. A study of the prevalence of restless legs syndrome in previously untreated Parkinson’s disease patients: absence of co-morbid association. J Neurol Sci 2011;310:286-288.
References_xml – reference: 5) Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121-132.
– reference: 1) Möller JC, Unger M, Stiasny-Kolster K, et al. Restless Legs Syndrome (RLS) and Parkinson’s disease (PD)-related disorders or different entities? J Neurol Sci 2010;289:135-137.
– reference: 9) Nomura T, Inoue Y, Miyake M, et al. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson’s disease. Mov Disord 2006;21:380-384.
– reference: 27) Okamura M, Suzuki K, Matsubara T, et al. Restlessness restricted to the perianal region in a patient with Parkinson’s disease. Parkinsonism Relat Disord 2018;51:117-118.
– reference: 18) Karroum EG, Leu-Semenescu S, Arnulf I. Topography of the sensations in primary restless legs syndrome. J Neurol Sci 2012;320:26-31.
– reference: 6) Takegami M, Suzukamo Y, Wakita T, et al. Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on item response theory. Sleep Med 2009;10:556-565.
– reference: 16) Moccia M, Erro R, Picillo M, et al. A Four-year longitudinal study on restless legs syndrome in Parkinson disease. Sleep 2016;39:405-412.
– reference: 12) Puschmann A, Pfeiffer RF, Stoessl AJ, et al. A family with Parkinsonism, essential tremor, restless legs syndrome, and depression. Neurology 2011;76:1623-1630.
– reference: 23) Turrini A, Raggi A, Calandra-Buonaura G, et al. Not only limbs in atypical restless legs syndrome. Sleep Med Rev 2018;38:50-55.
– reference: 7) Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 2015;30:1591-1601.
– reference: 14) Young JE, Vilarino-Guell C, Lin SC, et al. Clinical and genetic description of a family with a high prevalence of autosomal dominant restless legs syndrome. Mayo Clin Proc 2009;84:134-138.
– reference: 3) Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology 2011;77:1941-1946.
– reference: 11) Gan-Or Z, Alcalay RN, Rouleau GA, et al. Sleep disorders and Parkinson disease; lessons from genetics. Sleep Med Rev 2018.
– reference: 21) Garcia-Borreguero D, Cano-Pumarega I. New concepts in the management of restless legs syndrome. BMJ 2017;356:j104.
– reference: 4) Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med 2014;15:860-873.
– reference: 22) Kwon DY, Seo WK, Yoon HK, et al. Transcranial brain sonography in Parkinson’s disease with restless legs syndrome. Mov Disord 2010;25:1373-1378.
– reference: 10) Peralta CM, Frauscher B, Seppi K, et al. Restless legs syndrome in Parkinson’s disease. Mov Disord 2009;24:2076-2080.
– reference: 20) Earley CJ, Allen RP, Connor JR, et al. The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal. Sleep Med 2009;10:1155-1157.
– reference: 17) Wong JC, Li Y, Schwarzschild MA, et al. Restless legs syndrome: an early clinical feature of Parkinson disease in men. Sleep 2014;37:369-372.
– reference: 19) Gupta A, Shukla G, Mohammed A, et al. Restless legs syndrome, a predictor of subcortical stroke: a prospective study in 346 stroke patients. Sleep Med 2017;29:61-67.
– reference: 2) Angelini M, Negrotti A, Marchesi E, et al. A study of the prevalence of restless legs syndrome in previously untreated Parkinson’s disease patients: absence of co-morbid association. J Neurol Sci 2011;310:286-288.
– reference: 24) Suzuki K, Miyamoto M, Miyamoto T, et al. Restless “lower back” in a patient with Parkinson’s disease. Tremor Other Hyperkinet Mov (N Y) 2013;3.
– reference: 15) Dragan EM, Chen Z, Ondo WG. Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson’s disease: a pilot study. Int J Neurosci 2015;125:526-530.
– reference: 26) Aquino CC, Mestre T, Lang AE. Restless genital syndrome in Parkinson disease. JAMA Neurol 2014;71:1559-1561.
– reference: 25) 澤村正典，當間圭一郎，垂髪祐樹ら．陰部むずむず感で発症したパーキンソン病の1例．臨床神経 2015;55:266-268.
– reference: 8) Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002;59:421-424.
– reference: 13) Adel S, Djarmati A, Kabakci K, et al. Co-occurrence of restless legs syndrome and Parkin mutations in two families. Mov Disord 2006;21:258-263.
SSID ssib000959814
ssib058494234
ssib002821941
ssib000940416
ssib002484599
ssib005879791
ssj0060813
Score 2.1475892
Snippet 症例は57歳女性．33年間左半身の異常感覚による不眠があった．初診の前年から頻度が増加し，右下肢にも症状が出現するようになった．娘は20歳からレストレスレッグス症候群（restless legs syndrome;...
SourceID jstage
SourceType Publisher
StartPage 617
SubjectTerms RLS家族歴
RLS症状拡大
パーキンソン病
レストレスレッグス症候群
Title レストレスレッグス症候群の症状拡大と頻度増加がパーキンソン病の早期徴候と考えられた女性例
URI https://www.jstage.jst.go.jp/article/clinicalneurol/58/10/58_cn-001176/_article/-char/ja
Volume 58
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX 臨床神経学, 2018, Vol.58(10), pp.617-621
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR1NaxNBdCkVxIv4id94cI6p2ezM7sxxNt1SlApCC70tu5ssEiSK1IsHabKKte3FUxCEVqlWoYpQEfzqnxmT6L_wvdndZFOsaBHCMHnz5s372M28N5k3YxiXrMgKA4xOBI1FiVq2WQprYVCqWXGI01Ut1ElhM9fs6Tl6ZZ7Nj43fL2aXLIQT0b3f5pXsx6oAA7tiluw_WHZAFABQB_tCCRaG8q9sTDyLcIvIqq5UiCsyCOd7NmUQ_cmaygUchwiHcId4TO-B0BDXI5JqHJNIr4ADpSSuTTybcJdIE3sBpnRyZGBDEFkmrotNriTS1jgVpIBDSGxNkXnOmDCzipszLydzyIDnIiTlhxU4tBEiha5UiZjSo3vEpQW5BhxyhGTaMHPVVQgXeaWaNaV0JNOD2tgLJaVImbtFL1_TdDRxLTWICUxCR6G15zJNk6FccrAyip2Qa6oFomgWePwRKkEnTMsCZL0hPkOLZQoY4qdQrhlD0Yb4AoVDHWitAHcZPn6ZxIFA4YIO8TUBbAH8STRLhg9UpMhGFVPFdaNsksN3PDcCy4er_kEHeiwYXI5MogLmSH0jNLgQ6byJgRrmKRcnVsaLPyDlwjRpp_m6mcdlpznyuydzZgs8HDjPENbnu96ciJolfY7hrvPTtUeWvYj-aBefcR9CXSijpp_29QeYN4I7fgPiqwMVxzFxS_DV64XwRNDyyL_yggle2HVQoZwyMbJ8YRbzwhl3hDM8iwp8fQHRC809RRvc8cFNj6jQdKchyn15L6nBUW5A2JhvOdVe8OwR43AWvl6UqWBHjbFGcMw4OJNt0DluPFDJlmp_UslSXtlSSaLa76He7zzqLj7t72yo1juo95c_9laedzc2Vev1z_Uv3c-vui863eV11VpVyROVfFXttyrZVu1vUPY7D6FXr_Om92ytu_MB6ECvH4uJai2p9mPVXlWtte7L7d7i5vedlRPG3JQ3W50uZRe9lBrgbvBShI6DCOoB6NcMIcRkdgxRvxMFIq7E5TrDRS7H4nEFr8gyrahCRY0FzAmjKKK0Zp00xpu3mvVToL_ADqkVQxyHKfN1JkDtIaA7QSzqIopOG9Op_vzb6Wk-_r4fmjP_j9RZ4xC-ounS7jljfOHO3fp5CHYWwgv6ifwFza0oIg
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E3%83%AC%E3%82%B9%E3%83%88%E3%83%AC%E3%82%B9%E3%83%AC%E3%83%83%E3%82%B0%E3%82%B9%E7%97%87%E5%80%99%E7%BE%A4%E3%81%AE%E7%97%87%E7%8A%B6%E6%8B%A1%E5%A4%A7%E3%81%A8%E9%A0%BB%E5%BA%A6%E5%A2%97%E5%8A%A0%E3%81%8C%E3%83%91%E3%83%BC%E3%82%AD%E3%83%B3%E3%82%BD%E3%83%B3%E7%97%85%E3%81%AE%E6%97%A9%E6%9C%9F%E5%BE%B4%E5%80%99%E3%81%A8%E8%80%83%E3%81%88%E3%82%89%E3%82%8C%E3%81%9F%E5%A5%B3%E6%80%A7%E4%BE%8B&rft.jtitle=%E8%87%A8%E5%BA%8A%E7%A5%9E%E7%B5%8C%E5%AD%A6&rft.au=%E8%97%A4%E7%94%B0%2C+%E8%A3%95%E6%98%8E&rft.au=%E5%B9%B3%E7%94%B0%2C+%E5%B9%B8%E4%B8%80&rft.au=%E9%88%B4%E6%9C%A8%2C+%E5%9C%AD%E8%BC%94&rft.au=%E4%B8%AD%E6%9D%91%2C+%E5%88%A9%E7%94%9F&rft.date=2018&rft.pub=%E6%97%A5%E6%9C%AC%E7%A5%9E%E7%B5%8C%E5%AD%A6%E4%BC%9A&rft.issn=0009-918X&rft.eissn=1882-0654&rft.volume=58&rft.issue=10&rft.spage=617&rft.epage=621&rft_id=info:doi/10.5692%2Fclinicalneurol.cn-001176&rft.externalDocID=article_clinicalneurol_58_10_58_cn_001176_article_char_ja
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-918X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-918X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-918X&client=summon