Regulation of the Nuclear Factor (NF)-κB Pathway by ISGylation

• Published in: Biological and Pharmaceutical Bulletin Vol. 31; no. 12; pp. 2223 - 2227
• Main Authors: Takeuchi, Tomoharu, Sone, Takayuki, Minakawa, Miki, Yokosawa, Hideyoshi
• Format: Journal Article
• Language: English
• Published: The Pharmaceutical Society of Japan 01.12.2008
• Subjects: interferon-stimulated gene; nuclear factor-κB; post-translational modification; tumor necrosis factor receptor-associated factor 6; ubiquitin-conjugating enzyme
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.31.2223

Post-translational modification with ISG15 (interferon-stimulated gene 15 kDa) (ISGylation) is mediated by a sequential reaction similar to ubiquitination, and various target proteins for ISGylation have been identified. We previously reported that ISGylation of the E2 ubiquitin-conjugating enzyme U...