Voltage‐sensitive sodium channel mutations S989P + V1016G in Aedes aegypti confer variable resistance to pyrethroids, DDT and oxadiazines

• Published in: Pest management science Vol. 74; no. 3; pp. 737 - 745
• Main Authors: Smith, Letícia B, Kasai, Shinji, Scott, Jeffrey G
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2018; Wiley Subscription Services, Inc
• Subjects: Aedes - drug effects; Aedes - genetics; Aedes aegypti; animal pathogens; Animals; Aquatic insects; backcrossing; chemical structure; Cross-resistance; DDT; DDT (pesticide); DDT - pharmacology; Disease control; disease outbreaks; Electric potential; etofenprox; genes; genetic background; Genotypes; imagos; indoxacarb; Information management; Insect control; Insect Proteins - genetics; Insect Proteins - metabolism; Insecticide resistance; Insecticide Resistance - genetics; Insecticides; Insecticides - pharmacology; Metabolites; mosquito control; Mosquitoes; Mutation; Outbreaks; oxadiazine insecticides; Oxazines - pharmacology; Pest control; pyrethrins; Pyrethrins - pharmacology; pyrethroid resistance; Pyrethroids; resistance management; Rocks; Singapore; Sodium; sodium channel; sodium channels; Sodium channels (voltage-gated); Voltage-Gated Sodium Channels - genetics; Voltage-Gated Sodium Channels - metabolism; Vssc; Asia; Singapore; pyrethroid resistance; sodium channel; DDT; Vssc; oxadiazine insecticides

BACKGROUND Aedes aegypti is a vector of several important human pathogens. Control efforts rely primarily on pyrethroid insecticides for adult mosquito control, especially during disease outbreaks. A. aegypti has developed resistance nearly everywhere it occurs and insecticides are used. An importan...