分子状水素は人工心肺に伴う血管内皮グリコカリックスの障害を軽減する
血管内皮グリコカリックス (Endothelial Glycocalyx : EG) は血管内皮細胞の表面に存在し, 血管保護や炎症反応の抑制などの働きを持つ. 人工心肺 (Cardiopulmonary Bypass : CPB) は血液と体外回路との接触によって全身炎症が生じ, EGが障害されることが知られている....
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| Published in | Cardiovascular Anesthesia Vol. 28; no. 1; p. 177 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本心臓血管麻酔学会
01.09.2024
日本心臓血管麻酔学会 Japanese Society of Cardiovascular Anesthesiologists |
| Online Access | Get full text |
| ISSN | 1342-9132 1884-7439 |
| DOI | 10.11478/jscva.2024-4-001 |
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| Abstract | 血管内皮グリコカリックス (Endothelial Glycocalyx : EG) は血管内皮細胞の表面に存在し, 血管保護や炎症反応の抑制などの働きを持つ. 人工心肺 (Cardiopulmonary Bypass : CPB) は血液と体外回路との接触によって全身炎症が生じ, EGが障害されることが知られている. |
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| AbstractList | 血管内皮グリコカリックス (Endothelial Glycocalyx : EG) は血管内皮細胞の表面に存在し, 血管保護や炎症反応の抑制などの働きを持つ. 人工心肺 (Cardiopulmonary Bypass : CPB) は血液と体外回路との接触によって全身炎症が生じ, EGが障害されることが知られている. |
| Author | 加藤, 孝澄 岩田, 紘樹 |
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| Copyright | 2024 一般社団法人 日本心臓血管麻酔学会 |
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| References | 2) Laffey JG, Boylan JF, Cheng DCH. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology. 2002; 97: 215-52. 5) Shigeo Ohta. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther. 2014; 144: 1-11. 4) Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007; 13: 688-94. 1) Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019; 23: 16. 3) Dekker NAM, Veerhoek D, Koning NJ, et al. Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass. Anaesthesia. 2019; 74: 609-18. |
| References_xml | – reference: 4) Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007; 13: 688-94. – reference: 3) Dekker NAM, Veerhoek D, Koning NJ, et al. Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass. Anaesthesia. 2019; 74: 609-18. – reference: 2) Laffey JG, Boylan JF, Cheng DCH. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology. 2002; 97: 215-52. – reference: 1) Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019; 23: 16. – reference: 5) Shigeo Ohta. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther. 2014; 144: 1-11. |
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| Snippet | 血管内皮グリコカリックス (Endothelial Glycocalyx : EG) は血管内皮細胞の表面に存在し, 血管保護や炎症反応の抑制などの働きを持つ. 人工心肺 (Cardiopulmonary Bypass : CPB) は血液と体外回路との接触によって全身炎症が生じ, EGが障害されることが知られている. |
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| Title | 分子状水素は人工心肺に伴う血管内皮グリコカリックスの障害を軽減する |
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