TGF‐β1‐induced CK17 enhances cancer stem cell‐like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2‐MZF1 signaling pathway - Wu, Lanfang; Han, Lingfei; Zhou, Chenfei; Wei, Wenfei; Chen, Xiaojing; Yi, Hongyan; Wu, Xiangguang; Bai, Xiangyang; Guo, Suiqun; Yu, Yanhong; Liang, Li; Wang, Wei (The FEBS journal, 2017)
Keywords: Adult; Animals; cancer stem cell; Cell Line, Tumor; cervical cancer metastasis; CK17; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Keratin-17 - antagonists & inhibitors; Keratin-17 - genetics; Keratin-17 - metabolism; Kruppel-Like Transcription Factors - genetics; Kruppel-Like Transcription Factors - metabolism; Lymphatic Metastasis; metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase 1 - genetics; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - genetics; Mitogen-Activated Protein Kinase 3 - metabolism; Neoplasm Transplantation; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Signal Transduction; stem cells; TGF‐β1; therapeutics; transcription factors; transforming growth factor beta 1; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; uterine cervical neoplasms; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; cervical cancer metastasis; CK17; TGF-β1; epithelial-mesenchymal transition; cancer stem cell