ナノ粒子に対する補体活性化の功罪
補体系は、自然免疫系の1つであり、初期の異物認識機構で中心的な役割を果たしており、病原体だけでなく、人工のナノ粒子の排除にも深く関わっている。補体系の活性化（カスケード反応）に伴い、生物学的活性をもつさまざまな分子が生成され、異物の貪食や炎症反応を誘導している。ナノ粒子の物性に応じて補体の活性化の程度はさまざまに変化するため、ナノ粒子の予期せぬ体内動態変化や毒性発現が想定されている。このような現象はナノ粒子による薬物送達効率を低下させるため、ナノ粒子に対する補体活性化機構を理解することは、非常に重要である。一方で、補体活性化に伴う免疫活性化は、ナノ粒子を用いたワクチンへ応用することが可能である...
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| Published in | Drug Delivery System Vol. 32; no. 3; pp. 199 - 207 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Kawasaki
日本DDS学会
01.01.2017
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0913-5006 1881-2732 |
| DOI | 10.2745/dds.32.199 |
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| Abstract | 補体系は、自然免疫系の1つであり、初期の異物認識機構で中心的な役割を果たしており、病原体だけでなく、人工のナノ粒子の排除にも深く関わっている。補体系の活性化（カスケード反応）に伴い、生物学的活性をもつさまざまな分子が生成され、異物の貪食や炎症反応を誘導している。ナノ粒子の物性に応じて補体の活性化の程度はさまざまに変化するため、ナノ粒子の予期せぬ体内動態変化や毒性発現が想定されている。このような現象はナノ粒子による薬物送達効率を低下させるため、ナノ粒子に対する補体活性化機構を理解することは、非常に重要である。一方で、補体活性化に伴う免疫活性化は、ナノ粒子を用いたワクチンへ応用することが可能であると考えられる。本稿では、ナノ粒子に対する補体活性化の負と正の両側面について紹介する。 |
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| AbstractList | 補体系は、自然免疫系の1つであり、初期の異物認識機構で中心的な役割を果たしており、病原体だけでなく、人工のナノ粒子の排除にも深く関わっている。補体系の活性化（カスケード反応）に伴い、生物学的活性をもつさまざまな分子が生成され、異物の貪食や炎症反応を誘導している。ナノ粒子の物性に応じて補体の活性化の程度はさまざまに変化するため、ナノ粒子の予期せぬ体内動態変化や毒性発現が想定されている。このような現象はナノ粒子による薬物送達効率を低下させるため、ナノ粒子に対する補体活性化機構を理解することは、非常に重要である。一方で、補体活性化に伴う免疫活性化は、ナノ粒子を用いたワクチンへ応用することが可能であると考えられる。本稿では、ナノ粒子に対する補体活性化の負と正の両側面について紹介する。 Complement system is one of the central part of innate immunity partly responsible for recognition and removal of foreign materials, not only pathogens but also artificial nanoparticles. Complement system composed of more than 30 proteins causes cascade enzymatic activation, produces various bioactive substances, and finally induces inflammation and phagocytosis of foreign materials. It is well known that artificial nanoparticles activate complement system and physicochemical properties of nanoparticles affect level of complement activation, resulting in unexpected pharmacokinetics change of nanoparticles and toxicity. Hence, it is important to understand the mechanism behind complement activation by nanoparticles. In addition, intrinsic role of complement system in immune response is useful for development of vaccine. In this review, we introduce the negative and positive aspect of complement activation against nanoparticles. |
| Author | 清水, 太郎 石田, 竜弘 異島, 優 |
| Author_xml | – sequence: 1 fullname: 異島, 優 organization: 徳島大学大学院 医歯薬学研究部 薬物動態制御学分野 – sequence: 1 fullname: 清水, 太郎 organization: 徳島大学大学院 医歯薬学研究部 薬物動態制御学分野 – sequence: 1 fullname: 石田, 竜弘 organization: 徳島大学大学院 医歯薬学研究部 薬物動態制御学分野 |
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| SubjectTerms | Biocompatibility Complement Complement activation Immune response Immune system Immunity Innate immunity Nanoparticles Phagocytosis Pharmacokinetics Pharmacology Physicochemical properties Proteins Toxicity |
| Title | ナノ粒子に対する補体活性化の功罪 |
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