DDS技術を活用した体内再生誘導治療

Endogenous stem cells are promising sources for low-cost and minimally invasive regenerative medicine. Recent studies suggest that drug delivery system technologies are useful to promote proliferation, differentiation and migration of various types of cells during regeneration processes. In this pap...

Full description

Saved in:
Bibliographic Details
Published inDrug Delivery System Vol. 32; no. 1; pp. 46 - 49
Main Authors 澤本, 和延, 大塚, 隆信, 坪井, 義晃, 澤田, 雅人
Format Journal Article
LanguageJapanese
Published Kawasaki 日本DDS学会 01.01.2017
Japan Science and Technology Agency
Subjects
Antiretroviral drugs
Cell proliferation
Drug delivery
Drug delivery systems
Regeneration (physiology)
Regenerative medicine
Stem cells
Online AccessGet full text
ISSN0913-5006
1881-2732
DOI10.2745/dds.32.46

Cover

Abstract Endogenous stem cells are promising sources for low-cost and minimally invasive regenerative medicine. Recent studies suggest that drug delivery system technologies are useful to promote proliferation, differentiation and migration of various types of cells during regeneration processes. In this paper, we introduce recent progress in regenerative medicine using the drug delivery system.
AbstractList Endogenous stem cells are promising sources for low-cost and minimally invasive regenerative medicine. Recent studies suggest that drug delivery system technologies are useful to promote proliferation, differentiation and migration of various types of cells during regeneration processes. In this paper, we introduce recent progress in regenerative medicine using the drug delivery system.
体内に存在する組織幹細胞の研究が進み、それを用いた再生医療の開発が期待されている。内在性幹細胞を利用することができれば低コストで安全な治療が可能になると考えられるが、その実現のためには再生能力を促進する技術が必要である。内在性幹細胞の分化・誘導因子を局所に供給するドラッグデリバリー技術の有効性が種々の研究によって明らかにされ、臨床応用がなされているものもある。こうした取り組みの現状を紹介する。
Author 坪井, 義晃
澤本, 和延
大塚, 隆信
澤田, 雅人
Author_xml – sequence: 1
  fullname: 澤本, 和延
  organization: 自然科学研究機構生理学研究所 神経発達・再生機構研究部門
– sequence: 1
  fullname: 大塚, 隆信
  organization: 名古屋市立大学大学院　医学研究科　整形外科学分野
– sequence: 1
  fullname: 坪井, 義晃
  organization: 名古屋市立大学大学院　医学研究科　整形外科学分野
– sequence: 1
  fullname: 澤田, 雅人
  organization: 名古屋市立大学大学院　医学研究科　再生医学分野
BookMark eNo9UL1KA0EYXCSCSbTwGawvfvt3tws2kvgHAQu1Xvb2NpojJvEuKexMICkELUxArYKdWInYBZ_mTC6P4UnEZga-GWY-poByzVbTIrSJoUQ8xreDIC5RUmLuCspjIbBDPEpyKA8SU4cDuGuoEMchAMtEnEdQqZzMb28WL6Ok_zD_nKbj16T3mPQm31-j2XAwG96l48ni7Wn2fj__mKbP_XW0WtON2G78cRGd7e-dlg-d6vHBUXm36oRESukILAF8nxhjGGXGrflCMKm1ZzyefST9wPcN5mCp0BKI4cZocHlNioAHYDktoq1lbjtqXXVt3FFhqxs1s0pFADPGuEdk5tpZusK4o8-takf1Sx1dKx116qZhVTaHokThX2Du_9lc6EiFmv4AuatqQQ
ContentType Journal Article
Copyright 2017 日本DDS学会
Copyright Japan Science and Technology Agency 2017
Copyright_xml – notice: 2017 日本DDS学会
– notice: Copyright Japan Science and Technology Agency 2017
DBID 7QO
8FD
FR3
P64
DOI 10.2745/dds.32.46
DatabaseName Biotechnology Research Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
DatabaseTitle Engineering Research Database
Biotechnology Research Abstracts
Technology Research Database
Biotechnology and BioEngineering Abstracts
DatabaseTitleList Engineering Research Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1881-2732
EndPage 49
ExternalDocumentID article_dds_32_1_32_46_article_char_ja
GroupedDBID .55
2WC
53G
5GY
ACIWK
ACPRK
AFRAH
ALMA_UNASSIGNED_HOLDINGS
AUIBY
CS3
JSF
JSH
OK1
RJT
RZJ
X7M
7QO
8FD
FR3
P64
ID FETCH-LOGICAL-j2999-81900bb2ccc434c6fb8849aa7c757329bdbbc150e38a902c5cca065f98d5d0e53
ISSN 0913-5006
IngestDate Mon Jun 30 16:43:42 EDT 2025
Wed Sep 03 06:29:29 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 1
Language Japanese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-j2999-81900bb2ccc434c6fb8849aa7c757329bdbbc150e38a902c5cca065f98d5d0e53
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
OpenAccessLink https://www.jstage.jst.go.jp/article/dds/32/1/32_46/_article/-char/ja
PQID 2014445729
PQPubID 2048468
PageCount 4
ParticipantIDs proquest_journals_2014445729
jstage_primary_article_dds_32_1_32_46_article_char_ja
PublicationCentury 2000
PublicationDate 20170101
PublicationDateYYYYMMDD 2017-01-01
PublicationDate_xml – month: 01
  year: 2017
  text: 20170101
  day: 01
PublicationDecade 2010
PublicationPlace Kawasaki
PublicationPlace_xml – name: Kawasaki
PublicationTitle Drug Delivery System
PublicationTitleAlternate DDS
PublicationYear 2017
Publisher 日本DDS学会
Japan Science and Technology Agency
Publisher_xml – name: 日本DDS学会
– name: Japan Science and Technology Agency
References 24)Ajioka I et al., Tissue Engineering Part A 21(1-2),193-201(2015
15)Yamashita T. et al., J neurosci. 26,6627-6636(2006
18)Nakaguchi K et al., Stem Cells Int. 2012, Article ID 915160(2012
12)Eriksson PS et al., Nat Med.4, 1313-1317(1998
1)田畑泰彦, ICUとCCU ,34(5) 349-353(2010
20)Doeppner TR et al., Journal of Cerebral BloodflowandMetabolism 31(5),1251-1262(2011
6)Lederman RJ et al., Lancet 359, 2053-2058(2002
11)Altman J et al., J comp Neurol .137,433-457(1968
3)Suri C et al., Science 282,468-471(1998
19)Koojiman R et al., Stroke. 40(4),e83-88(2009
23)Zhou K et al., PloS one, 11, e0151589.(2016
10)Indrawattana N et al., Res Commun 320(3),914-919(2004
22)Fon D et al., Biomaterials 35, 2692-2712(2014
4)Zeng H et al., PLoS ONE 7, e35905(2012
8)Kronenberg HM et al., Nature 423(6937), 332-336(2003
9)Ohba S et al., FASEB J. 21(8), 1777-1787(2009
16)Kojima t et al., Stem cells 28, 545-554(2010
14)doetsch F et al., Cell 97,703-716(1999
2)Isner,J.M et al.,Circulation.197,1114-1123(1998
7)Marui A et al., Circ J71-, 1181-1186(2007
17)Arvidsson A. et al., Nat.med.8,963-970(2002
21)Fon D et al., Advanced healthcare materials, 3, 761-774(2014
13)Sanai N et al., Nature 427,740-744(2004
5)Morishita R et al., Hypertension 44,203-209(2004
References_xml – reference: 13)Sanai N et al., Nature 427,740-744(2004)
– reference: 16)Kojima t et al., Stem cells 28, 545-554(2010)
– reference: 7)Marui A et al., Circ J71-, 1181-1186(2007)
– reference: 18)Nakaguchi K et al., Stem Cells Int. 2012, Article ID 915160(2012)
– reference: 17)Arvidsson A. et al., Nat.med.8,963-970(2002)
– reference: 4)Zeng H et al., PLoS ONE 7, e35905(2012)
– reference: 11)Altman J et al., J comp Neurol .137,433-457(1968)
– reference: 15)Yamashita T. et al., J neurosci. 26,6627-6636(2006)
– reference: 5)Morishita R et al., Hypertension 44,203-209(2004)
– reference: 3)Suri C et al., Science 282,468-471(1998)
– reference: 23)Zhou K et al., PloS one, 11, e0151589.(2016)
– reference: 24)Ajioka I et al., Tissue Engineering Part A 21(1-2),193-201(2015)
– reference: 9)Ohba S et al., FASEB J. 21(8), 1777-1787(2009)
– reference: 1)田畑泰彦, ICUとCCU ,34(5) 349-353(2010)
– reference: 2)Isner,J.M et al.,Circulation.197,1114-1123(1998)
– reference: 22)Fon D et al., Biomaterials 35, 2692-2712(2014)
– reference: 6)Lederman RJ et al., Lancet 359, 2053-2058(2002)
– reference: 12)Eriksson PS et al., Nat Med.4, 1313-1317(1998)
– reference: 10)Indrawattana N et al., Res Commun 320(3),914-919(2004)
– reference: 14)doetsch F et al., Cell 97,703-716(1999)
– reference: 19)Koojiman R et al., Stroke. 40(4),e83-88(2009)
– reference: 20)Doeppner TR et al., Journal of Cerebral BloodflowandMetabolism 31(5),1251-1262(2011)
– reference: 8)Kronenberg HM et al., Nature 423(6937), 332-336(2003)
– reference: 21)Fon D et al., Advanced healthcare materials, 3, 761-774(2014)
SSID ssj0048811
ssib058492641
ssib007483962
ssib001535732
ssib002484529
Score 2.066834
Snippet ...
Endogenous stem cells are promising sources for low-cost and minimally invasive regenerative medicine. Recent studies suggest that drug delivery system...
SourceID proquest
jstage
SourceType Aggregation Database
Publisher
StartPage 46
SubjectTerms Antiretroviral drugs
Cell proliferation
Drug delivery
Drug delivery systems
Regeneration (physiology)
Regenerative medicine
Stem cells
Title DDS技術を活用した体内再生誘導治療
URI https://www.jstage.jst.go.jp/article/dds/32/1/32_46/_article/-char/ja
https://www.proquest.com/docview/2014445729
Volume 32
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Drug Delivery System, 2017/01/25, Vol.32(1), pp.46-49
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FcuGCeIpCQTmwvbQJjr2O10eHOKpKKUU4UjhZ3l2nkKIY1bFQeqKV6AEJDrQScKq4IU6AuFX8mpCkP4NZ27FDqRBwWW32JXtnPPlmdmYWoZucC6UNyk_JJLpfIoY8JKwKpcSJISgHfM2ZjB2-u1pdapLllt4qFL5MeS1FPVbmWyfGlfwPVaEN6CqjZP-Bstmi0AB1oC-UQGEo_4rG9foDbFcxtaS_gk2xVcGmhm0NUxWbquyqEVyrYdvAJsEWjbtgjDGpNLANA-rxLB1TWEqfVOrpLDkGVrawSWVXTcHUjldWJyubOLnYZ4Jx65vR-oLwn0iPj36aKjozEIQRC2IHgodB-OgxwNfMxOM984SXhA-FXi_IrL-9MNqI2x1vw-sGLJqeAYwWJE4hW1HWlxoxKsYxI8YyAINcmskTg_xgYcGKg1CnLZfAWrqipBm0E7lNaUVGGf0i2HPDacbAiZROjJ7H_zxAP5d5NoQIy5paJick6F695zaaKyuuY7ecU-i0ahixZ8Cd-9MHj5puTGeEI1QebWe_DQKINM_QCPDPBEiaeSWBOI2vjM7eMUmGJR_tVvZgAJY6oDqs_44fYlDknENnU22maCWseR4VOt4FNL-WpEPvLxadPLovXCzOF9fyROn9i0gB_h29fH70YW-w82b07XC8_3Gw_XawffDj-95w98Vw99V4_-Do07vh59ejr4fj9zuXULNhO7eXSukNHqWOKtNbSLipMKZyzolGeLXNKLyw5xnckLtkMsEYB5XE16hnKirXQZ4AJm6bVOhC8XXtMprpBl3_CioqPqAoQrhf1TVSFYQxItpCIlgiVMX3Z5GebIr7NEnT4qafpQv75mqqW5GFjMBPm2VUo9vxZtHcZA_d9NMOXVXaGYgOiufVP3dfQ2dydp5DM73NyL8OKLXHbsR88RNNQYu3
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DDS%E6%8A%80%E8%A1%93%E3%82%92%E6%B4%BB%E7%94%A8%E3%81%97%E3%81%9F%E4%BD%93%E5%86%85%E5%86%8D%E7%94%9F%E8%AA%98%E5%B0%8E%E6%B2%BB%E7%99%82&rft.jtitle=Drug+delivery+system&rft.au=Tsuboi%2C+Yoshiaki&rft.au=Sawada%2C+Masato&rft.au=Otsuka%2C+Takanobu&rft.au=Sawamoto%2C+Kazunobu&rft.date=2017-01-01&rft.pub=Japan+Science+and+Technology+Agency&rft.issn=0913-5006&rft.eissn=1881-2732&rft.volume=32&rft.issue=1&rft.spage=46&rft_id=info:doi/10.2745%2Fdds.32.46&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0913-5006&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0913-5006&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0913-5006&client=summon