Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells

• Published in: Kobe journal of the medical sciences Vol. 66; no. 3; pp. E94 - E101
• Main Authors: Matovelo, Shubi Ambwene, Zhang, Lifang, Mohamed, Nesma Nabil Ibrahim, Kajimoto, Taketoshi, Ijuin, Takeshi, Okada, Taro, Nakamura, Shun-Ichi
• Format: Journal Article
• Language: English
• Published: Japan Kobe University School Of Medicine 2020
• Subjects: macropinocytosis; EGF; S1P receptor; sphingosine kinase; Sphingosine 1-phosphate

Macropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of c...