亜鉛生物学と亜鉛シグナルの基礎知識

「はじめに」 亜鉛は生命の維持に必須である. ヒトの体内での存在量としては鉄の次に多い必須微量元素であるが, 亜鉛が生命維持の必須であることの理由にはあまり注目を集めてこなかった. 本稿では, 「なぜ亜鉛は生命に必要であるのか?」, 亜鉛生物学と亜鉛シグナルの基礎的な情報と研究の系譜をふまえて概論したい. 「亜鉛生物学の歴史」 亜鉛の金属の発見は他の主要な金属と比べるとその歴史は新しく, ドイツ人のアンドレアス・マルクグラーフが1746年に報告したのが最初とされている. 日本以外の漢字文化圏では「シン」の文字で表しているが, 日本では寺島良案が和漢三才図会で「亜鉛」と記して紹介しており, この...

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Published inBIOMEDICAL RESEARCH ON TRACE ELEMENTS Vol. 26; no. 1; pp. 1 - 6
Main Author 深田, 俊幸
Format Journal Article
LanguageJapanese
Published 日本微量元素学会 08.05.2015
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ISSN0916-717X
1880-1404
DOI10.11299/brte.26.1

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Abstract 「はじめに」 亜鉛は生命の維持に必須である. ヒトの体内での存在量としては鉄の次に多い必須微量元素であるが, 亜鉛が生命維持の必須であることの理由にはあまり注目を集めてこなかった. 本稿では, 「なぜ亜鉛は生命に必要であるのか?」, 亜鉛生物学と亜鉛シグナルの基礎的な情報と研究の系譜をふまえて概論したい. 「亜鉛生物学の歴史」 亜鉛の金属の発見は他の主要な金属と比べるとその歴史は新しく, ドイツ人のアンドレアス・マルクグラーフが1746年に報告したのが最初とされている. 日本以外の漢字文化圏では「シン」の文字で表しているが, 日本では寺島良案が和漢三才図会で「亜鉛」と記して紹介しており, この記述が日本で亜鉛に負のイメージを与えるきっかけになったともいわれている. 亜鉛が生命に必須であることを示す報告は, 1869年にコウジカビ(Aspergillus niger)を用いた研究が最初であるとされている.
AbstractList 「はじめに」 亜鉛は生命の維持に必須である. ヒトの体内での存在量としては鉄の次に多い必須微量元素であるが, 亜鉛が生命維持の必須であることの理由にはあまり注目を集めてこなかった. 本稿では, 「なぜ亜鉛は生命に必要であるのか?」, 亜鉛生物学と亜鉛シグナルの基礎的な情報と研究の系譜をふまえて概論したい. 「亜鉛生物学の歴史」 亜鉛の金属の発見は他の主要な金属と比べるとその歴史は新しく, ドイツ人のアンドレアス・マルクグラーフが1746年に報告したのが最初とされている. 日本以外の漢字文化圏では「シン」の文字で表しているが, 日本では寺島良案が和漢三才図会で「亜鉛」と記して紹介しており, この記述が日本で亜鉛に負のイメージを与えるきっかけになったともいわれている. 亜鉛が生命に必須であることを示す報告は, 1869年にコウジカビ(Aspergillus niger)を用いた研究が最初であるとされている.
Author 深田, 俊幸
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References [18] Miyai T, Hojyo S, Ikawa T, Kawamura M, Irie T, et al. (2014) Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A 111: 11780–11785.
[5] Kambe T, Suzuki T, Nagao M, Yamaguchi-Iwai Y (2006) Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Genomics Proteomics Bioinformatics 4: 1–9.
[19] Citiulo F, Jacobsen ID, Miramon P, Schild L, Brunke S, et al. (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog 8: e1002777.
[10] Adlard PA, Parncutt JM, Finkelstein DI, Bush AI (2010) Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer’s disease? J Neurosci 30: 1631–1636.
[25] Fukada T, Hojyo S, Bin B (2014) Zinc signal in growth control and bone diseases. In: Fukada T, Kambe T, editors. Zinc signals in cellular functions and disorders. Tokyo: Springer. pp. 249–267.
[1] 化学：物質と人間の歴史；大学教育研究会，（1985）開成出版.
[8] Maret W (2013) Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr 4: 82–91.
[2] Prasad AS, Halsted JA, Nadimi M (1961) Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 31: 532–546.
[11] Homma K, Fujisawa T, Tsuburaya N, Yamaguchi N, Kadowaki H, et al. (2013) SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency. Mol Cell 52: 75–86.
[6] Fukada T, Kambe T (2011) Molecular and genetic features of zinc transporters in physiology and pathogenesis. Metallomics 3: 662–674.
[12] Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A 110: 9903–9908.
[17] Hogstrand C, Kille P, Nicholson RI, Taylor KM (2009) Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends Mol Med 15: 101–111.
[22] Nam H, Wang CY, Zhang L, Zhang W, Hojyo S, et al. (2013) ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica 98: 1049–1057.
[7] Kambe T (2014) Introduction: “Zinc Signaling”-The Blossoming field of Zinc Biology. In: Fukada T, Kambe T, editors. Zinc signals in cellular functions and disorders. Tokyo: Springer. pp. 1–5.
[20] Stafford SL, Bokil NJ, Achard ME, Kapetanovic R, Schembri MA, et al. (2013) Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper. Biosci Rep 33.
[14] Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, et al. (2012) LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol 422: 556–574.
[21] Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, et al. (2014) The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration. PLoS Pathog 10: e1004450.
[9] 深田俊幸（2010）私の学会聞き歩き：エルサレムで感じた「亜鉛生物学」の胎動．細胞工学 29: 386–389.
[24] Kambe T, Tsuji T, Fukue K (2014) Zinc Transporter Proteins and Zinc Signaling. In: Fukada T, Kambe T, editors. Zinc signals in cellular functions and disorders. Tokyo: Springer. pp. 27–53.
[3] Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T (2011) Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem 16: 1123–1134.
[15] Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, et al. (2013) The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 123: 4513–4524.
[23] Yang H, Shu Y (2015) Cadmium Transporters in the Kidney and Cadmium-Induced Nephrotoxicity. Int J Mol Sci 16: 1484–1494.
[16] Rutter GA, Hodson DJ (2014) Beta cell connectivity in pancreatic islets: a type 2 diabetes target? Cell Mol Life Sci.
[13] Gazzellone MJ, Zhou X, Lionel AC, Uddin M, Thiruvahindrapuram B, et al. (2014) Copy number variation in Han Chinese individuals with autism spectrum disorder. J Neurodev Disord 6: 34.
[4] Maret W (2012) New perspectives of zinc coordination environments in proteins. J Inorg Biochem 111: 110–116.
References_xml – reference: [5] Kambe T, Suzuki T, Nagao M, Yamaguchi-Iwai Y (2006) Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Genomics Proteomics Bioinformatics 4: 1–9.
– reference: [12] Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A 110: 9903–9908.
– reference: [23] Yang H, Shu Y (2015) Cadmium Transporters in the Kidney and Cadmium-Induced Nephrotoxicity. Int J Mol Sci 16: 1484–1494.
– reference: [24] Kambe T, Tsuji T, Fukue K (2014) Zinc Transporter Proteins and Zinc Signaling. In: Fukada T, Kambe T, editors. Zinc signals in cellular functions and disorders. Tokyo: Springer. pp. 27–53.
– reference: [18] Miyai T, Hojyo S, Ikawa T, Kawamura M, Irie T, et al. (2014) Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A 111: 11780–11785.
– reference: [20] Stafford SL, Bokil NJ, Achard ME, Kapetanovic R, Schembri MA, et al. (2013) Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper. Biosci Rep 33.
– reference: [1] 化学：物質と人間の歴史；大学教育研究会，（1985）開成出版.
– reference: [10] Adlard PA, Parncutt JM, Finkelstein DI, Bush AI (2010) Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer’s disease? J Neurosci 30: 1631–1636.
– reference: [13] Gazzellone MJ, Zhou X, Lionel AC, Uddin M, Thiruvahindrapuram B, et al. (2014) Copy number variation in Han Chinese individuals with autism spectrum disorder. J Neurodev Disord 6: 34.
– reference: [17] Hogstrand C, Kille P, Nicholson RI, Taylor KM (2009) Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends Mol Med 15: 101–111.
– reference: [25] Fukada T, Hojyo S, Bin B (2014) Zinc signal in growth control and bone diseases. In: Fukada T, Kambe T, editors. Zinc signals in cellular functions and disorders. Tokyo: Springer. pp. 249–267.
– reference: [9] 深田俊幸（2010）私の学会聞き歩き：エルサレムで感じた「亜鉛生物学」の胎動．細胞工学 29: 386–389.
– reference: [19] Citiulo F, Jacobsen ID, Miramon P, Schild L, Brunke S, et al. (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog 8: e1002777.
– reference: [15] Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, et al. (2013) The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 123: 4513–4524.
– reference: [22] Nam H, Wang CY, Zhang L, Zhang W, Hojyo S, et al. (2013) ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica 98: 1049–1057.
– reference: [2] Prasad AS, Halsted JA, Nadimi M (1961) Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 31: 532–546.
– reference: [4] Maret W (2012) New perspectives of zinc coordination environments in proteins. J Inorg Biochem 111: 110–116.
– reference: [3] Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T (2011) Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem 16: 1123–1134.
– reference: [16] Rutter GA, Hodson DJ (2014) Beta cell connectivity in pancreatic islets: a type 2 diabetes target? Cell Mol Life Sci.
– reference: [6] Fukada T, Kambe T (2011) Molecular and genetic features of zinc transporters in physiology and pathogenesis. Metallomics 3: 662–674.
– reference: [7] Kambe T (2014) Introduction: “Zinc Signaling”-The Blossoming field of Zinc Biology. In: Fukada T, Kambe T, editors. Zinc signals in cellular functions and disorders. Tokyo: Springer. pp. 1–5.
– reference: [11] Homma K, Fujisawa T, Tsuburaya N, Yamaguchi N, Kadowaki H, et al. (2013) SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency. Mol Cell 52: 75–86.
– reference: [14] Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, et al. (2012) LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol 422: 556–574.
– reference: [21] Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, et al. (2014) The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration. PLoS Pathog 10: e1004450.
– reference: [8] Maret W (2013) Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr 4: 82–91.
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Snippet 「はじめに」 亜鉛は生命の維持に必須である. ヒトの体内での存在量としては鉄の次に多い必須微量元素であるが, 亜鉛が生命維持の必須であることの理由にはあまり注目を集めてこなかった. 本稿では, 「なぜ亜鉛は生命に必要であるのか?」, 亜鉛生物学と亜鉛シグナルの基礎的な情報と研究の系譜をふまえて概論したい....
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Title 亜鉛生物学と亜鉛シグナルの基礎知識
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