Guillain-Barré症候群およびFisher症候群の再発に関する臨床分析

13年間で入院加療したGuillain-Barré症候群（Guillain-Barré syndrome; GBS）53例，Fisher症候群（Fisher syndrome; FS）37例，両者重複3例の再発を検討した．再発症例はFSの4例（女性）再発率10.8％で，GBSの再発はみとめず，FSの再発が明らかに高頻度であった．4例中2例はFSの再発（再発率5.4％），2例はFSとGBSの重複型（再発率5.4％）であり，再発回数の合計は6回で，うち2回はFSで，4回はFSとGBSの重複型であった．GQ1b抗体は初発，再発時と全例出現し，転帰は再発をふくめ良好な経過であった．...

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Published in臨床神経学 Vol. 54; no. 7; pp. 577 - 580
Main Authors 音成, 秀一郎, 高松, 和弘, 吉本, 武史, 竹島, 慎一, 栗山, 勝, 下江, 豊, 姫野, 隆洋
Format Journal Article
LanguageJapanese
Published 日本神経学会 01.07.2014
Subjects
Fisher症候群
Guillain-Barré症候群
再発
抗GQ1b抗体
Online AccessGet full text
ISSN0009-918X
1882-0654
DOI10.5692/clinicalneurol.54.577

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Abstract 13年間で入院加療したGuillain-Barré症候群（Guillain-Barré syndrome; GBS）53例，Fisher症候群（Fisher syndrome; FS）37例，両者重複3例の再発を検討した．再発症例はFSの4例（女性）再発率10.8％で，GBSの再発はみとめず，FSの再発が明らかに高頻度であった．4例中2例はFSの再発（再発率5.4％），2例はFSとGBSの重複型（再発率5.4％）であり，再発回数の合計は6回で，うち2回はFSで，4回はFSとGBSの重複型であった．GQ1b抗体は初発，再発時と全例出現し，転帰は再発をふくめ良好な経過であった．
AbstractList 13年間で入院加療したGuillain-Barré症候群（Guillain-Barré syndrome; GBS）53例，Fisher症候群（Fisher syndrome; FS）37例，両者重複3例の再発を検討した．再発症例はFSの4例（女性）再発率10.8％で，GBSの再発はみとめず，FSの再発が明らかに高頻度であった．4例中2例はFSの再発（再発率5.4％），2例はFSとGBSの重複型（再発率5.4％）であり，再発回数の合計は6回で，うち2回はFSで，4回はFSとGBSの重複型であった．GQ1b抗体は初発，再発時と全例出現し，転帰は再発をふくめ良好な経過であった．
Author 吉本, 武史
音成, 秀一郎
栗山, 勝
下江, 豊
竹島, 慎一
姫野, 隆洋
高松, 和弘
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  fullname: 高松, 和弘
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  fullname: 吉本, 武史
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  fullname: 竹島, 慎一
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  fullname: 栗山, 勝
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  fullname: 下江, 豊
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  fullname: 姫野, 隆洋
  organization: 脳卒中センター大田記念病院脳神経内科
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References 4) Winer JB. Guillain-Barré syndrome. BMJ 2008;337:227-231.
5) Heckmann JG, Dütsch M. Recurrent Miller Fisher syndrome: clinical and laboratory features. Eur J Neurol 2012;19:944-954.
3) Das A, Kalita J, Misra UK. Recurrent Guillain-Barré syndrome. Electromyogr Clin Neurophysiol 2004;44:95-102.
2) Winer JB. Guillain-Barré syndrome: clinical variants and their pathogenesis. J Neuroimmunol 2011;231:70-72.
7) Chida K, Nomura H, Konno H, et al. Recurrent Miller Fisher syndrome: clinical and laboratory features and HLA antigens. J Neurol Sci 1999;165:139-143.
8) 楠進，荻原美枝子，神田隆ら．ギラン・バレー症候群フィッシャー症候群診療ガイドライン2013．東京：南江堂；2013. p. 176.
9) Funakoshi K, Kuwabara S, Odaka M, et al. Clinical predictors of mechanical ventilation in Fisher/Guillain-Barré overlap syndrome. J Neurol Neurosurg Psychiatry 2009;80:60-64.
1) van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol 2008;7:939-950.
6) Kuitwaard K, van Koningsveld R, Ruts L, et al. Recurrent Guillain-Barre’ syndrome. J Neurol Neurosurg Psychiatry 2009;80:56-59.
10) Chiba A, Kusunoki S, Obata H, et al. Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barré syndrome: clinical and immunohistochemical studies. Neurology 1993;43:1911-1917.
References_xml – reference: 1) van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol 2008;7:939-950.
– reference: 2) Winer JB. Guillain-Barré syndrome: clinical variants and their pathogenesis. J Neuroimmunol 2011;231:70-72.
– reference: 4) Winer JB. Guillain-Barré syndrome. BMJ 2008;337:227-231.
– reference: 7) Chida K, Nomura H, Konno H, et al. Recurrent Miller Fisher syndrome: clinical and laboratory features and HLA antigens. J Neurol Sci 1999;165:139-143.
– reference: 5) Heckmann JG, Dütsch M. Recurrent Miller Fisher syndrome: clinical and laboratory features. Eur J Neurol 2012;19:944-954.
– reference: 3) Das A, Kalita J, Misra UK. Recurrent Guillain-Barré syndrome. Electromyogr Clin Neurophysiol 2004;44:95-102.
– reference: 8) 楠進，荻原美枝子，神田隆ら．ギラン・バレー症候群フィッシャー症候群診療ガイドライン2013．東京：南江堂；2013. p. 176.
– reference: 6) Kuitwaard K, van Koningsveld R, Ruts L, et al. Recurrent Guillain-Barre’ syndrome. J Neurol Neurosurg Psychiatry 2009;80:56-59.
– reference: 10) Chiba A, Kusunoki S, Obata H, et al. Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barré syndrome: clinical and immunohistochemical studies. Neurology 1993;43:1911-1917.
– reference: 9) Funakoshi K, Kuwabara S, Odaka M, et al. Clinical predictors of mechanical ventilation in Fisher/Guillain-Barré overlap syndrome. J Neurol Neurosurg Psychiatry 2009;80:60-64.
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Snippet 13年間で入院加療したGuillain-Barré症候群（Guillain-Barré syndrome; GBS）53例，Fisher症候群（Fisher syndrome;...
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SubjectTerms Fisher症候群
Guillain-Barré症候群
再発
抗GQ1b抗体
Title Guillain-Barré症候群およびFisher症候群の再発に関する臨床分析
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