β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

• Published in: Science (American Association for the Advancement of Science) Vol. 359; no. 6379; pp. 1056 - 1061
• Main Authors: Moriyama Saya, Brestoff, Jonathan R, Flamar Anne-Laure, Moeller, Jesper B, Klose Christoph S N, Rankin, Lucille C, Yudanin, Naomi A, Monticelli, Laurel A, Putzel Gregory Garbès, Hans-Reimer, Rodewald, Artis, David
• Format: Journal Article
• Language: English
• Published: Washington The American Association for the Advancement of Science 02.03.2018
• Subjects: Adrenergic receptors; Allergens; Anatomy; Cell proliferation; Cytokines; Down-regulation; Environmental effects; Eosinophils; Epinephrine; Immunity; Inflammation; Inflammatory response; Leukocytes (eosinophilic); Lungs; Lymphoid cells; Mice; Nervous system; Rodents; Small intestine

An off switch for helminth immunityGroup 2 innate lymphoid cells (ILC2s) are involved in responses to helminths, viruses, and allergens. Moriyama et al. found that ILC2s interact with the nervous system to modulate helminth immunity. ILC2s from the small intestine expressed the β2-adrenergic recepto...