PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

• Published in: The Journal of clinical investigation Vol. 124; no. 5; pp. 2246 - 2259
• Main Authors: Gros, Alena, Robbins, Paul F, Yao, Xin, Li, Yong F, Turcotte, Simon, Tran, Eric, Wunderlich, John R, Mixon, Arnold, Farid, Shawn, Dudley, Mark E, Hanada, Ken-Ichi, Almeida, Jorge R, Darko, Sam, Douek, Daniel C, Yang, James C, Rosenberg, Steven A
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.05.2014
• Subjects: Adoptive Transfer; Antigens, CD - genetics; Antigens, CD - immunology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; Cell Line, Tumor; Female; Hepatitis A Virus Cellular Receptor 2; Humans; Male; Melanoma - genetics; Melanoma - immunology; Melanoma - pathology; Melanoma - therapy; Membrane Proteins - genetics; Membrane Proteins - immunology; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - immunology; Receptors, Antigen, T-Cell, alpha-beta - genetics; Receptors, Antigen, T-Cell, alpha-beta - immunology; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics; Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology

Adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate regression of metastatic melanoma; however, TILs are a heterogeneous population, and there are no effective markers to specifically identify and select the repertoire of tumor-reactive and mutation-specific CD8⁺ lymphocytes. The...