The SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and hamsters

• Published in: Nature
• Main Authors: Diamond, Michael, Halfmann, Peter, Maemura, Tadashi, Iwatsuki-Horimoto, Kiyoko, Iida, Shun, Kiso, Maki, Scheaffer, Suzanne, Darling, Tamarand, Joshi, Astha, Loeber, Samantha, Foster, Stephanie, Ying, Baoling, Whitener, Bradley, Floyd, Katharine, Ujie, Michiko, Nakajima, Noriko, Ito, Mutsumi, Wright, Ryan, Uraki, Ryuta, Li, Rong, Sakai, Yuko, Liu, Yanan, Larson, Deanna, Osorio, Jorge, Hernandez-Ortiz, Juan, Čiuoderis, Karl, Florek, Kelsey, Patel, Mit, Bateman, Allen, Odle, Abby, Wong, Lok-Yin, Wang, Zhongde, Edara, Venkata Viswanadh, Chong, Zhenlu, Thackray, Larissa, Ueki, Hiroshi, Yamayoshi, Seiya, Imai, Masaki, Perlman, Stanley, Webby, Richard, Seder, Robert, Suthar, Mehul, Garcia-Sastre, Adolfo, Schotsaert, Michael, Suzuki, Tadaki, Boon, Adrianus, Kawaoka, Yoshihiro, Douek, Daniel, Moliva, Juan, Sullivan, Nancy, Gagne, Matthew, Ransier, Amy, Case, James, Jeevan, Trushar, Franks, John, Fabrizio, Thomas, DeBeauchamp, Jennifer, Kercher, Lisa, Seiler, Patrick, Singh, Gagandeep, Warang, Prajakta, Gonzalez-Reiche, Ana S, Sordillo, Emilia, van Bakel, Harm, Simon, Viviana
• Format: Journal Article Web Resource
• Language: English; Japanese
• Published: United States Research Square 29.12.2021
• Subjects: Disease; Infections; Mutation; Severe acute respiratory syndrome coronavirus 2

Despite the development and deployment of antibody and vaccine countermeasures, rapidly-spreading SARS-CoV-2 variants with mutations at key antigenic sites in the spike protein jeopardize their efficacy. The recent emergence of B.1.1.529, the Omicron variant1,2, which has more than 30 mutations in t...