日本人のハイリスク妊娠におけるレストレスレッグス症候群/Willis-Ekbom病の有病率、臨床像及び分娩アウトカム
妊娠中にレストレスレッグス症候群/Willis-Ekbom病（RLS/WED）は高率となる。本研究は日本の地域周産期母子医療センターにて入院管理を必要とした合併症を有するハイリスク妊産婦81人を対象としてRLS/WEDの有病率調査を行った。さらに、RLS/WEDと臨床像、分娩アウトカムとの関連について検討を行った。RLS/WEDが確定的、もしくは疑われる妊産婦は14人（17.3％）であった。妊娠前よりRLS/WEDの症状が出現していた者は9人（64.3％）であった。RLS/WEDと妊娠合併症、血清フェリチン値、血清葉酸値、分娩アウトカムとの関連性は認められなかった。ハイリスク日本人妊婦における...
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| Published in | 看護科学研究 Vol. 14; no. 3; pp. 66 - 72 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
大分県立看護科学大学看護研究交流センター
2016
Oita University of Nursing and Health Sciences The Center for Nursing Education, Research and Collaboration (CNERC) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2424-0052 |
| DOI | 10.20705/jjnhs.14.3_66 |
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| Abstract | 妊娠中にレストレスレッグス症候群/Willis-Ekbom病（RLS/WED）は高率となる。本研究は日本の地域周産期母子医療センターにて入院管理を必要とした合併症を有するハイリスク妊産婦81人を対象としてRLS/WEDの有病率調査を行った。さらに、RLS/WEDと臨床像、分娩アウトカムとの関連について検討を行った。RLS/WEDが確定的、もしくは疑われる妊産婦は14人（17.3％）であった。妊娠前よりRLS/WEDの症状が出現していた者は9人（64.3％）であった。RLS/WEDと妊娠合併症、血清フェリチン値、血清葉酸値、分娩アウトカムとの関連性は認められなかった。ハイリスク日本人妊婦におけるRLS/WED有症状率は同年代の女性と比べて高率で、妊娠前のRLS/WEDはハイリスク妊娠と関連することが推察された。今後、RLS/WED女性における妊娠前からの前向き調査が必要である。 |
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| AbstractList | 妊娠中にレストレスレッグス症候群/Willis-Ekbom病（RLS/WED）は高率となる。本研究は日本の地域周産期母子医療センターにて入院管理を必要とした合併症を有するハイリスク妊産婦81人を対象としてRLS/WEDの有病率調査を行った。さらに、RLS/WEDと臨床像、分娩アウトカムとの関連について検討を行った。RLS/WEDが確定的、もしくは疑われる妊産婦は14人（17.3％）であった。妊娠前よりRLS/WEDの症状が出現していた者は9人（64.3％）であった。RLS/WEDと妊娠合併症、血清フェリチン値、血清葉酸値、分娩アウトカムとの関連性は認められなかった。ハイリスク日本人妊婦におけるRLS/WED有症状率は同年代の女性と比べて高率で、妊娠前のRLS/WEDはハイリスク妊娠と関連することが推察された。今後、RLS/WED女性における妊娠前からの前向き調査が必要である。 Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is prevalent during pregnancy. We investigated the prevalence of RLS/WED among 81 high-risk pregnant women requiring hospitalization, at a perinatal medical center in Japan. We also assessed the relationship between RLS/WED and clinical features as well as delivery outcomes in these subjects. A definite or probable RLS/WED was identified in 14 subjects (17.3%). Nine of the 14 subjects (64.3%) had symptoms of RLS/WED before pregnancy. No significant differences were found in the delivery outcomes and pregnancy complications or the level of hemoglobin, ferritin, and folate between the RLS/WED group and the non- RLS/WED group. The frequency of detecting RLS/WED in high-risk pregnant Japanese women was greater compared to the frequency in non-pregnant women of the same age group. It is speculated that RLS/WED before pregnancy is associated with high-risk pregnancy. In the future, a prospective study among RLS/WED women from pre-pregnancy will be required. 妊娠中にレストレスレッグス症候群/Willis-Ekbom病（RLS/WED）は高率となる。本研究は日本の地域周産期母子医療センターにて入院管理を必要とした合併症を有するハイリスク妊産婦81人を対象としてRLS/WEDの有病率調査を行った。さらに、RLS/WEDと臨床像、分娩アウトカムとの関連について検討を行った。RLS/WEDが確定的、もしくは疑われる妊産婦は14人（17.3％）であった。妊娠前よりRLS/WEDの症状が出現していた者は9人（64.3％）であった。RLS/WEDと妊娠合併症、血清フェリチン値、血清葉酸値、分娩アウトカムとの関連性は認められなかった。ハイリスク日本人妊婦におけるRLS/WED有症状率は同年代の女性と比べて高率で、妊娠前のRLS/WEDはハイリスク妊娠と関連することが推察された。今後、RLS/WED女性における妊娠前からの前向き調査が必要である。 |
| Author | 坂本, 遥 近藤, 英明 江藤, 宏美 加藤, 千穂 |
| Author_FL | 江藤 宏美 Sakamoto Haruka Kondo Hideaki Kato Chiho |
| Author_FL_xml | – sequence: 1 fullname: Sakamoto Haruka – sequence: 2 fullname: Kato Chiho – sequence: 3 fullname: 江藤 宏美 – sequence: 4 fullname: Kondo Hideaki |
| Author_xml | – sequence: 1 fullname: 江藤, 宏美 organization: 長崎大学大学院 医歯薬学総合研究科 保健学専攻看護学講座 リプロダクティブヘルス分野 – sequence: 1 fullname: 近藤, 英明 organization: 長崎大学大学院 医歯薬学総合研究科 社会医療科学講座 総合診療学 – sequence: 1 fullname: 加藤, 千穂 organization: 長崎大学大学院 医歯薬学総合研究科 保健学専攻看護学講座 リプロダクティブヘルス分野 – sequence: 1 fullname: 坂本, 遥 organization: 淀川キリスト教病院 |
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| Copyright | 2016 看護科学研究編集委員会 |
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| DocumentTitleAlternate | Prevalence, clinical features, and delivery outcomes of restless legs syndrome/Willis-Ekbom disease among high risk Japanese pregnancies |
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| References | Oyieng'o DO, Kirwa K, Tong I et al (2016). Restless Legs Symptoms and Pregnancy and Neonatal Outcomes. Clin Ther 38, 256-264. Suzuki K, Ohida T, Sone T et al (2003). The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 26, 673-677. Bosco D, Plastino M, Fava A et al (2009). Role of the Oral Glucose Tolerance Test (OGTT) in theidiopathic restless legs syndrome. J Neurol Sci 287, 60-63. Uglane MT, Westad S and Backe B (2011).Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis. Acta Obstet Gynecol Scand 90, 1046-1048. Ko H, Shin J, Kim MY et al (2012). Sleep disturbances in Korean pregnant and postpartum women. J Psychosom Obstet Gynaecol 33, 85-90. Chen PH, Liou KC, Chen CP et al (2012). Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. Sleep Med 13, 1153-1157. Lee KA, Zaffke ME and Baratte-Beebe K (2001). Restless legs syndrome and sleep disturbanceduring pregnancy: the role of folate and iron. J Womens Health Gend Based Med 10, 335-341. Wei X, Yang L, and Tang X (2013). Survey on restless legs syndrome in pregnant Chinese women. Sleep and Biological Rhythms 11, 286-287. Allen RP, Picchietti DL, Garcia-Borreguero D et al (2014). Restless legs syndrome/Willis-Ekbomdisease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG)consensus criteria--history, rationale, description, and significance. Sleep Med 15, 860-873. Harano S, Ohida T, Kaneita Y et al (2008). Prevalence of restless legs syndrome with pregnancy and the relationship with sleep disorders in the Japanese large population. Sleep and Biological Rhythms 6, 102-109. Picchietti DL, Hensley JG, Bainbridge JL et al (2015). Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev 22, 64-77. Alves DA, Carvalho LB, Morais JF et al (2010).Restless legs syndrome during pregnancy in Brazilian women. Sleep Med 11, 1049-1054. Shang X, Yang J, Guo Y et al (2014). Restless legs syndrome among pregnant women in China:prevalence and risk factors. Sleep Breath 19, 1093-1099. Liu G, Li L, Zhang J et al (2016). Restless legs syndrome and pregnancy or delivery complicationsin China: a representative survey. Sleep Med 17, 158-162. Hubner A, Krafft A, Gadient S et al (2013). Characteristics and determinants of restless legs syndrome in pregnancy: a prospective study. Neurology 80, 738-742. Inoue Y, Oka Y, Kagimura T et al (2013). Reliability, validity, and responsiveness of the Japanese version of International Restless Legs Syndrome Study Group rating scale for restless legs syndrome in a clinical trial setting. Psychiatry Clin Neurosci 67, 412-419. Nomura T, Inoue Y, Kusumi M et al (2008). Prevalence of restless legs syndrome in a rural community in Japan. Mov Disord 23, 2363-2369. Ma S, Shang X, Guo Y et al (2015). Restless legs syndrome and hypertension in Chinese pregnantwomen. Neurol Sci 36, 877-881. Neyal A, Senel GB, Aslan R et al (2015). A prospective study of Willis-Ekbom disease/restlesslegs syndrome during and after pregnancy. Sleep Med 16, 1036-1040. 小林美奈, 加藤一成, 鍵村達夫 他(2013). レストレスレッグス症候群（RLS）の重症度評価における日本語版IRLS ver2.2の信頼性および妥当性の検討. 睡眠医療 7, 100-105. Szentkiralyi A, Volzke H, Hoffmann W et al (2014). Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies. Neurology 82, 2026-2033. Bourguet CC, Ober SK, Panzner MP et al (2009). Evaluation of a screening interview for restless legs syndrome. Acta Neurol Scand 120, 24-29. Dzaja A, Wehrle R, Lancel M et al (2009). Elevated estradiol plasma levels in women with restless legs during pregnancy. Sleep 32, 169-174. |
| References_xml | – reference: Wei X, Yang L, and Tang X (2013). Survey on restless legs syndrome in pregnant Chinese women. Sleep and Biological Rhythms 11, 286-287. – reference: Picchietti DL, Hensley JG, Bainbridge JL et al (2015). Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev 22, 64-77. – reference: Shang X, Yang J, Guo Y et al (2014). Restless legs syndrome among pregnant women in China:prevalence and risk factors. Sleep Breath 19, 1093-1099. – reference: Allen RP, Picchietti DL, Garcia-Borreguero D et al (2014). Restless legs syndrome/Willis-Ekbomdisease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG)consensus criteria--history, rationale, description, and significance. Sleep Med 15, 860-873. – reference: Alves DA, Carvalho LB, Morais JF et al (2010).Restless legs syndrome during pregnancy in Brazilian women. Sleep Med 11, 1049-1054. – reference: Lee KA, Zaffke ME and Baratte-Beebe K (2001). Restless legs syndrome and sleep disturbanceduring pregnancy: the role of folate and iron. J Womens Health Gend Based Med 10, 335-341. – reference: Szentkiralyi A, Volzke H, Hoffmann W et al (2014). Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies. Neurology 82, 2026-2033. – reference: Hubner A, Krafft A, Gadient S et al (2013). Characteristics and determinants of restless legs syndrome in pregnancy: a prospective study. Neurology 80, 738-742. – reference: Ma S, Shang X, Guo Y et al (2015). Restless legs syndrome and hypertension in Chinese pregnantwomen. Neurol Sci 36, 877-881. – reference: Nomura T, Inoue Y, Kusumi M et al (2008). Prevalence of restless legs syndrome in a rural community in Japan. Mov Disord 23, 2363-2369. – reference: Chen PH, Liou KC, Chen CP et al (2012). Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. Sleep Med 13, 1153-1157. – reference: Inoue Y, Oka Y, Kagimura T et al (2013). Reliability, validity, and responsiveness of the Japanese version of International Restless Legs Syndrome Study Group rating scale for restless legs syndrome in a clinical trial setting. Psychiatry Clin Neurosci 67, 412-419. – reference: Dzaja A, Wehrle R, Lancel M et al (2009). Elevated estradiol plasma levels in women with restless legs during pregnancy. Sleep 32, 169-174. – reference: Ko H, Shin J, Kim MY et al (2012). Sleep disturbances in Korean pregnant and postpartum women. J Psychosom Obstet Gynaecol 33, 85-90. – reference: 小林美奈, 加藤一成, 鍵村達夫 他(2013). レストレスレッグス症候群（RLS）の重症度評価における日本語版IRLS ver2.2の信頼性および妥当性の検討. 睡眠医療 7, 100-105. – reference: Neyal A, Senel GB, Aslan R et al (2015). A prospective study of Willis-Ekbom disease/restlesslegs syndrome during and after pregnancy. Sleep Med 16, 1036-1040. – reference: Bosco D, Plastino M, Fava A et al (2009). Role of the Oral Glucose Tolerance Test (OGTT) in theidiopathic restless legs syndrome. J Neurol Sci 287, 60-63. – reference: Harano S, Ohida T, Kaneita Y et al (2008). Prevalence of restless legs syndrome with pregnancy and the relationship with sleep disorders in the Japanese large population. Sleep and Biological Rhythms 6, 102-109. – reference: Liu G, Li L, Zhang J et al (2016). Restless legs syndrome and pregnancy or delivery complicationsin China: a representative survey. Sleep Med 17, 158-162. – reference: Suzuki K, Ohida T, Sone T et al (2003). The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 26, 673-677. – reference: Uglane MT, Westad S and Backe B (2011).Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis. Acta Obstet Gynecol Scand 90, 1046-1048. – reference: Bourguet CC, Ober SK, Panzner MP et al (2009). Evaluation of a screening interview for restless legs syndrome. Acta Neurol Scand 120, 24-29. – reference: Oyieng'o DO, Kirwa K, Tong I et al (2016). Restless Legs Symptoms and Pregnancy and Neonatal Outcomes. Clin Ther 38, 256-264. |
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| Snippet | ... Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is prevalent during pregnancy. We investigated the prevalence of RLS/WED among 81 high-risk pregnant... |
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| SubjectTerms | high risk pregnancy pregnancy prevalence restless legs syndrome/Willis-Ekbom disease ハイリスク妊娠 レストレスレッグス症候群/Willis-Ekbom病 妊娠 有病率 |
| Title | 日本人のハイリスク妊娠におけるレストレスレッグス症候群/Willis-Ekbom病の有病率、臨床像及び分娩アウトカム |
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