インプラント周囲の歯槽骨頂部に骨増生を認めた ビスフォスフォネート治療患者の3症例
The present report describes abnormal bone hyperplasia at the alveolar crest between implants placed around the mandibular molar area in three patients who have been medicated with bisphosphonate for osteoporosis. All three patients were female, and were aged 66, 68 and 67 years old. They complained...
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| Published in | Journal of Japanese Society of Oral Implantology Vol. 28; no. 2; pp. 160 - 167 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本口腔インプラント学会
2015
Japanese Society of Oral Implantology |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0914-6695 2187-9117 |
| DOI | 10.11237/jsoi.28.160 |
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| Abstract | The present report describes abnormal bone hyperplasia at the alveolar crest between implants placed around the mandibular molar area in three patients who have been medicated with bisphosphonate for osteoporosis. All three patients were female, and were aged 66, 68 and 67 years old. They complained of difficulty of brushing beneath the superstructure of implants. Dental radiography showed a band-like radiopacity at the alveolar bone crest between the mandibular molar implants. They were diagnosed with bone hyperplasia in the mandible. The lesion was surgically resected under local anesthesia after removing the superstructure in 2 of 3 patients, and sclerosis and normal bone tissue were observed histologically. These findings highlight the need for clinicians to monitor patients receiving bisphosphonate therapy. |
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| AbstractList | The present report describes abnormal bone hyperplasia at the alveolar crest between implants placed around the mandibular molar area in three patients who have been medicated with bisphosphonate for osteoporosis. All three patients were female, and were aged 66, 68 and 67 years old. They complained of difficulty of brushing beneath the superstructure of implants. Dental radiography showed a band-like radiopacity at the alveolar bone crest between the mandibular molar implants. They were diagnosed with bone hyperplasia in the mandible. The lesion was surgically resected under local anesthesia after removing the superstructure in 2 of 3 patients, and sclerosis and normal bone tissue were observed histologically. These findings highlight the need for clinicians to monitor patients receiving bisphosphonate therapy. |
| Author | 小澤, 重雄 又賀, 泉 渡沼, 敏夫 金子, 昌豊 根岸, 邦雄 |
| Author_FL | MATAGA Izumi WATANUMA Toshio OZAWA Shigeo KANEKO Masatoyo NEGISHI Kunio |
| Author_FL_xml | – sequence: 1 fullname: NEGISHI Kunio – sequence: 2 fullname: OZAWA Shigeo – sequence: 3 fullname: KANEKO Masatoyo – sequence: 4 fullname: WATANUMA Toshio – sequence: 5 fullname: MATAGA Izumi |
| Author_xml | – sequence: 1 fullname: 小澤, 重雄 organization: 関東・甲信越支部（埼玉インプラント研究会） – sequence: 1 fullname: 金子, 昌豊 organization: 関東・甲信越支部（埼玉インプラント研究会） – sequence: 1 fullname: 又賀, 泉 organization: 日本歯科大学生命歯学部口腔外科学講座 – sequence: 1 fullname: 根岸, 邦雄 organization: 関東・甲信越支部（埼玉インプラント研究会） – sequence: 1 fullname: 渡沼, 敏夫 organization: 関東・甲信越支部（埼玉インプラント研究会） |
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| Copyright | 2015 公益社団法人日本口腔インプラント学会 |
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| DocumentTitleAlternate | Bone Hyperplasia at the Alveolar Bone Crest around Implants in Three Patients Receiving Bisphosphonate Therapy |
| DocumentTitle_FL | Bone Hyperplasia at the Alveolar Bone Crest around Implants in Three Patients Receiving Bisphosphonate Therapy |
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| References | 1) 島原政治，有吉靖則，今井 裕，ほか．ビスフォスフォネート投与と関連があると考えられる顎骨骨髄炎ならびに顎骨壊死に関連する調査．日口外誌 2007；49：594-602 6) 渡邉文彦，松浦正朗，春日井昇平，ほか．口腔インプラント治療指針， 第1版， 東京： 医歯薬出版，13-22，2012 4) 藤田日登美，代田達夫，菊池雄一，ほか．インプラント周囲に発症したビスフォスフォネート製剤関連顎骨壊死の1例．日口腔インプラント誌 2013；26：266-271 10) Bone HG, Hosking D, Devogelaer JP, et al. Ten years' experience with alendronate for osteoporosis in postmenopausal women. Alendronate phase Ⅲ Osteoporosis Treatment Study Group. N Engl J Med 2004;18:1189-1199. 3) 室井悠里，中嶋正博，正重裕一，ほか．経口ビスフォスフォネート製剤服用患者の抜歯創治癒経過に関する臨床的検討．日口外誌 2011；57：452-458 12) 井上 孝，武田孝之．インプラントの病理と臨床，第1版．東京：日本歯科評論，135-137，1999 15) Javed M, Almas K. Osseointegration of dental implants in patients undergoing bisphosphonate treatment: A literature review. J Periodontol 2010; 81:479-484. 7) 米田俊之，萩野 浩，杉本利嗣，ほか．ビスフォスフォネート関連顎骨壊死に関するポジションペーパー．日歯周病会誌 2010；52：265-269 2) 山下智巳，松本裕樹，浅香雄一郎，ほか．経口ビスフォスフォネート製剤に関連した下顎骨壊死の治療経験．日口外誌 2008；54：243-247 5) Grant B-T, Amenedo C, Freeman K, et al. Outcomes of placing dental implants in patients taking oral bisphosphonates: A review of 115 cases. J Oral Maxillofac Surg 2008; 66: 223-230. 14) 浦出雅裕．ビスフォスフォネート系薬剤と顎骨壊死：臨床病態と治療ガイドライン2008，日本口腔外科学会，1-5，2008 9) Marx RE:木村博人:顎骨壊死を誘発するビスフォスフ ォネート 経口薬あるいは静脈薬歴史，病因，予防，治療， 第1版，東京: クインテッセンス出版;9-37，2009:Oral & Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws, 2nd ed, Chicago:Quintessence Pub;2007. 11) Rocha ML, Malacara JM, Sanchez-Marin FJ, et al. Effect of alendronate on periodontal disease in postmenopausal women: A randomized placebo-controlled trial. J Periodontol 2004; 75: 1579-1585. 8) Yoneda T, Hagino H, Sugimoto T, et al. Bisphpsphonaterelated osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons. J Bone Miner Metab. 2010; 28: 365-383. 13) 石川悟朗，秋吉正豊．口腔病理学Ⅱ，増補版．京都：永末書店，806-816，1971 |
| References_xml | – reference: 5) Grant B-T, Amenedo C, Freeman K, et al. Outcomes of placing dental implants in patients taking oral bisphosphonates: A review of 115 cases. J Oral Maxillofac Surg 2008; 66: 223-230. – reference: 2) 山下智巳，松本裕樹，浅香雄一郎，ほか．経口ビスフォスフォネート製剤に関連した下顎骨壊死の治療経験．日口外誌 2008；54：243-247． – reference: 15) Javed M, Almas K. Osseointegration of dental implants in patients undergoing bisphosphonate treatment: A literature review. J Periodontol 2010; 81:479-484. – reference: 3) 室井悠里，中嶋正博，正重裕一，ほか．経口ビスフォスフォネート製剤服用患者の抜歯創治癒経過に関する臨床的検討．日口外誌 2011；57：452-458． – reference: 14) 浦出雅裕．ビスフォスフォネート系薬剤と顎骨壊死：臨床病態と治療ガイドライン2008，日本口腔外科学会，1-5，2008． – reference: 7) 米田俊之，萩野 浩，杉本利嗣，ほか．ビスフォスフォネート関連顎骨壊死に関するポジションペーパー．日歯周病会誌 2010；52：265-269． – reference: 6) 渡邉文彦，松浦正朗，春日井昇平，ほか．口腔インプラント治療指針， 第1版， 東京： 医歯薬出版，13-22，2012． – reference: 8) Yoneda T, Hagino H, Sugimoto T, et al. Bisphpsphonaterelated osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons. J Bone Miner Metab. 2010; 28: 365-383. – reference: 10) Bone HG, Hosking D, Devogelaer JP, et al. Ten years' experience with alendronate for osteoporosis in postmenopausal women. Alendronate phase Ⅲ Osteoporosis Treatment Study Group. N Engl J Med 2004;18:1189-1199. – reference: 11) Rocha ML, Malacara JM, Sanchez-Marin FJ, et al. Effect of alendronate on periodontal disease in postmenopausal women: A randomized placebo-controlled trial. J Periodontol 2004; 75: 1579-1585. – reference: 1) 島原政治，有吉靖則，今井 裕，ほか．ビスフォスフォネート投与と関連があると考えられる顎骨骨髄炎ならびに顎骨壊死に関連する調査．日口外誌 2007；49：594-602． – reference: 4) 藤田日登美，代田達夫，菊池雄一，ほか．インプラント周囲に発症したビスフォスフォネート製剤関連顎骨壊死の1例．日口腔インプラント誌 2013；26：266-271． – reference: 9) Marx RE:木村博人:顎骨壊死を誘発するビスフォスフ ォネート 経口薬あるいは静脈薬歴史，病因，予防，治療， 第1版，東京: クインテッセンス出版;9-37，2009:Oral & Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws, 2nd ed, Chicago:Quintessence Pub;2007. – reference: 12) 井上 孝，武田孝之．インプラントの病理と臨床，第1版．東京：日本歯科評論，135-137，1999． – reference: 13) 石川悟朗，秋吉正豊．口腔病理学Ⅱ，増補版．京都：永末書店，806-816，1971． |
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| SubjectTerms | bisphosphonate related bone hyperplasia osteoporosis |
| Title | インプラント周囲の歯槽骨頂部に骨増生を認めた ビスフォスフォネート治療患者の3症例 |
| URI | https://www.jstage.jst.go.jp/article/jsoi/28/2/28_160/_article/-char/ja https://cir.nii.ac.jp/crid/1390282680486532096 |
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| ispartofPNX | 日本口腔インプラント学会誌, 2015/06/30, Vol.28(2), pp.160-167 |
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