傾斜機能構造を有する生体模倣セラミックスの特性と巨細胞出現の評価
We developed a hypothesis that dissoluble absorption and giant cellular absorption are indispensable for bio- ceramics harmonized with bone remodeling. The aim of this study was to investigate the characteristics of porous and modified ceramics and the number of giant cells in subcutaneous tissue. C...
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| Published in | Journal of Japanese Society of Oral Implantology Vol. 27; no. 4; pp. 513 - 520 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本口腔インプラント学会
2014
Japanese Society of Oral Implantology |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0914-6695 2187-9117 |
| DOI | 10.11237/jsoi.27.513 |
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| Abstract | We developed a hypothesis that dissoluble absorption and giant cellular absorption are indispensable for bio- ceramics harmonized with bone remodeling. The aim of this study was to investigate the characteristics of porous and modified ceramics and the number of giant cells in subcutaneous tissue. Commercial products of b-tricalcium phosphate (β-TCP (porosity:75%)) were easily modified to functionally graded calcium phosphate ceramics by the partial dissolution–precipitation (PDP) technique, which involved a stirring of 300 rpm in 2% HNO3 solutions (50 cm3) containing Ca2＋ and PO43- ions and a supersonic treatment at 120 W and 38 kHz in the same solutions. The dissolution efficiency of porous bTCP block by the supersonic treatment drastically increased with time, depending on the porosity of ceramics. For even dense β-TCP block, enhancement of micro-pores and propagation of nano-cracks were recognized by the supersonic treatment for 7 min.
After the specific PDP technique, Nano-crystals of HAp were successfully precipitated on all over the pore wall surface in the macro- and micro-pores of the ceramics. The PDP-TCP (Partial Dissolution-Precipitation technique-TCP) ceramics were implanted into the back subcutis in 4 week-old Wistar rats. At 3 weeks after the implantation, the PDP-TCP exhibited a significant increase in the number of osteoclast-like giant cells and better affinity for body fluid than original β-TCP products. The results suggested that our PDP treated β-TCP could have a potential for a bioactive scaffold with good giant cell-absorption. |
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| AbstractList | We developed a hypothesis that dissoluble absorption and giant cellular absorption are indispensable for bio- ceramics harmonized with bone remodeling. The aim of this study was to investigate the characteristics of porous and modified ceramics and the number of giant cells in subcutaneous tissue. Commercial products of b-tricalcium phosphate (β-TCP (porosity:75%)) were easily modified to functionally graded calcium phosphate ceramics by the partial dissolution–precipitation (PDP) technique, which involved a stirring of 300 rpm in 2% HNO3 solutions (50 cm3) containing Ca2＋ and PO43- ions and a supersonic treatment at 120 W and 38 kHz in the same solutions. The dissolution efficiency of porous bTCP block by the supersonic treatment drastically increased with time, depending on the porosity of ceramics. For even dense β-TCP block, enhancement of micro-pores and propagation of nano-cracks were recognized by the supersonic treatment for 7 min.
After the specific PDP technique, Nano-crystals of HAp were successfully precipitated on all over the pore wall surface in the macro- and micro-pores of the ceramics. The PDP-TCP (Partial Dissolution-Precipitation technique-TCP) ceramics were implanted into the back subcutis in 4 week-old Wistar rats. At 3 weeks after the implantation, the PDP-TCP exhibited a significant increase in the number of osteoclast-like giant cells and better affinity for body fluid than original β-TCP products. The results suggested that our PDP treated β-TCP could have a potential for a bioactive scaffold with good giant cell-absorption. |
| Author | 永易, 裕樹 村田, 勝 南田, 康人 赤澤, 敏之 草野, 薫 |
| Author_FL | AKAZAWA Toshiyuki KUSANO Kaoru MURATA Masaru MINAMIDA Yasuhito NAGAYASU Hiroki |
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| Copyright | 2014 公益社団法人日本口腔インプラント学会 |
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| DocumentTitleAlternate | Characterization of Biomimetics Ceramics with Functionally Graded Structure and Evaluation of Expressing Giant Cells |
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| References | 1) Tamai N, Myoui A, Tomita T, et al. Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J Biomed Mater Res 2002; 59: 110-117. 22) Okada S, Oaki Y, Komotori J, et al. Control of cellular activity of osteoblastic cells with microtopography of biphasic calcium phosphate scaffolds. J Ceramic Soc Jpn 2011; 119: 635-639. 10) Ogose A, Kondo N, Umezu H. Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferions) in human bones. Biomaterials 2006; 27: 1542-1549. 21) Guy Daculsi. Micro Macroporous Calcium Phosphate Bioceramics. BUSINESS BRIEFING:GLOBAL SURGERY 2004: 117-122. 3) Tanaka T, Kumagae Y, Saito M, et al. Bone formation and resorption in patients after implantation of beta-tricalcium phosphate blocks with 60% and 75% porosity in opening-wedge high tibial osteotomy. J Biomed Mater Res B Appl Biomater 2008; 86B: 453-459. 7) 名井 陽．人工骨の歴史と最新デザインコンセプト．人工臓器 2011； 40：76-80. 8) Dong J, Uemura T, Shirasaki T, et al. Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells. Biomaterials 2002; 23: 4493-4502. 11) Sakamoto M, Nakasu M, Matsumoto T, et al:Development of Superporous hydroxyapatites and their examination with a culture of primary rat osteoblasts. J Biomed Mater Res 2007; 82: 238-242. 4) 小笠原健文，五百蔵一男，藤原寿彦，ほか．アパタイトブロック長期填入例のCT による検討(抄)．日口腔インプラント誌 2000；13：180. 14) Akazawa T, Murata M, Takahata M, et al. Characterization of microstructure and bio-absorption of the hydroxyapatite ceramics modified by a partial dissolution precipitation technique using supersonic treatment. J Ceram Soc of Jpn 2010; 118: 535-540. 2) Ogose A, Kondo N, Umezu H, et al. Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferions) in human bones. Biomaterials 2006; 27: 1542-1549 6) 北所弘行，舞田健夫，村田 勝，ほか．部分溶解析出処理により作製したリン酸カルシウムセラミックスのBMP-2 徐放特性と骨誘導特性．日口腔インプラント誌 2013； 26： 242-249. 17) Akao M, Aoki H, Kato K. Mechanical properties of sintered hydroxyapatite for prosthetic application. J Mater Sci 1981: 16; 809-812. 18) 松井 昌．Bioceramics の場における生体機能ガラスセラミックスの開発研究，Ⅰ．特に歯学的応用への展開．Quintessence 1988；7：421-436. 16) Sakamoto M, Matsumoto T. Development and Evaluation of Superporous Ceramics Bone Tissue Scaffold Materials with Triple Pore Structure A)Hydroxyapatite, B) Beta-Tricalcium Phosphate. Haim Tal, Bone Regeneration, Croatia:INTECH, 301-320, 2012. 15) Xianjun Ding, Takahata M, Akazawa T, et al. Improved Bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface. J Mater Sci 2011; 22: 1247-1255. 5) 佐々木智也，村田 勝，赤澤敏之，ほか．生体模倣傾斜機能アパタイトの生体内吸収特性．日口腔インプラント誌 2007； 7： 439-447. 12) Kikuchi, Itoh S, Ichinose S, et al. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 2001; 22: 1705-1711. 13) 田崎純一，村田 勝，赤澤敏之，ほか．生体模倣傾斜機能アパタイトの生体内崩壊性とBone MorphogeneticProtein-2 用量依存性骨誘導実験．日口腔インプラント誌2007； 20： 423-432. 19) Le Nihouannen D, Daculsi G, Saffarzadeh A, et al. Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. Bone 2005; 36: 1086-1093. 9) 小澤正宏，森川 茂．β-TCP の特徴と臨床応用．関節外科 2002； 21：1494-1500. 20) 村越琢磨，小林訓史．ハイドロキシアパタイト／β型リン酸三カルシウム複合材料．日本複合材料学会誌 2012；38：116-126. |
| References_xml | – reference: 6) 北所弘行，舞田健夫，村田 勝，ほか．部分溶解析出処理により作製したリン酸カルシウムセラミックスのBMP-2 徐放特性と骨誘導特性．日口腔インプラント誌 2013； 26： 242-249. – reference: 15) Xianjun Ding, Takahata M, Akazawa T, et al. Improved Bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface. J Mater Sci 2011; 22: 1247-1255. – reference: 17) Akao M, Aoki H, Kato K. Mechanical properties of sintered hydroxyapatite for prosthetic application. J Mater Sci 1981: 16; 809-812. – reference: 14) Akazawa T, Murata M, Takahata M, et al. Characterization of microstructure and bio-absorption of the hydroxyapatite ceramics modified by a partial dissolution precipitation technique using supersonic treatment. J Ceram Soc of Jpn 2010; 118: 535-540. – reference: 22) Okada S, Oaki Y, Komotori J, et al. Control of cellular activity of osteoblastic cells with microtopography of biphasic calcium phosphate scaffolds. J Ceramic Soc Jpn 2011; 119: 635-639. – reference: 9) 小澤正宏，森川 茂．β-TCP の特徴と臨床応用．関節外科 2002； 21：1494-1500. – reference: 16) Sakamoto M, Matsumoto T. Development and Evaluation of Superporous Ceramics Bone Tissue Scaffold Materials with Triple Pore Structure A)Hydroxyapatite, B) Beta-Tricalcium Phosphate. Haim Tal, Bone Regeneration, Croatia:INTECH, 301-320, 2012. – reference: 21) Guy Daculsi. Micro Macroporous Calcium Phosphate Bioceramics. BUSINESS BRIEFING:GLOBAL SURGERY 2004: 117-122. – reference: 1) Tamai N, Myoui A, Tomita T, et al. Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J Biomed Mater Res 2002; 59: 110-117. – reference: 18) 松井 昌．Bioceramics の場における生体機能ガラスセラミックスの開発研究，Ⅰ．特に歯学的応用への展開．Quintessence 1988；7：421-436. – reference: 19) Le Nihouannen D, Daculsi G, Saffarzadeh A, et al. Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. Bone 2005; 36: 1086-1093. – reference: 11) Sakamoto M, Nakasu M, Matsumoto T, et al:Development of Superporous hydroxyapatites and their examination with a culture of primary rat osteoblasts. J Biomed Mater Res 2007; 82: 238-242. – reference: 5) 佐々木智也，村田 勝，赤澤敏之，ほか．生体模倣傾斜機能アパタイトの生体内吸収特性．日口腔インプラント誌 2007； 7： 439-447. – reference: 4) 小笠原健文，五百蔵一男，藤原寿彦，ほか．アパタイトブロック長期填入例のCT による検討(抄)．日口腔インプラント誌 2000；13：180. – reference: 2) Ogose A, Kondo N, Umezu H, et al. Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferions) in human bones. Biomaterials 2006; 27: 1542-1549 – reference: 20) 村越琢磨，小林訓史．ハイドロキシアパタイト／β型リン酸三カルシウム複合材料．日本複合材料学会誌 2012；38：116-126. – reference: 12) Kikuchi, Itoh S, Ichinose S, et al. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 2001; 22: 1705-1711. – reference: 10) Ogose A, Kondo N, Umezu H. Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferions) in human bones. Biomaterials 2006; 27: 1542-1549. – reference: 13) 田崎純一，村田 勝，赤澤敏之，ほか．生体模倣傾斜機能アパタイトの生体内崩壊性とBone MorphogeneticProtein-2 用量依存性骨誘導実験．日口腔インプラント誌2007； 20： 423-432. – reference: 7) 名井 陽．人工骨の歴史と最新デザインコンセプト．人工臓器 2011； 40：76-80. – reference: 3) Tanaka T, Kumagae Y, Saito M, et al. Bone formation and resorption in patients after implantation of beta-tricalcium phosphate blocks with 60% and 75% porosity in opening-wedge high tibial osteotomy. J Biomed Mater Res B Appl Biomater 2008; 86B: 453-459. – reference: 8) Dong J, Uemura T, Shirasaki T, et al. Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells. Biomaterials 2002; 23: 4493-4502. |
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| SubjectTerms | biphasic calcium phosphate Functionally graded structure giant celladsorption |
| Title | 傾斜機能構造を有する生体模倣セラミックスの特性と巨細胞出現の評価 |
| URI | https://www.jstage.jst.go.jp/article/jsoi/27/4/27_513/_article/-char/ja https://cir.nii.ac.jp/crid/1390001205511195264 |
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| ispartofPNX | 日本口腔インプラント学会誌, 2014/12/31, Vol.27(4), pp.513-520 |
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