Evaluation of Stability of Temozolomide in Solutions after Opening the Capsule

• Published in: YAKUGAKU ZASSHI Vol. 129; no. 3; pp. 353 - 357
• Main Authors: KODAWARA, Takaaki, MIZUNO, Tomoyuki, TAUE, Hiromi, HASHIDA, Tohru, YANO, Ikuko, KATSURA, Toshiya, INUI, Ken-ichi
• Format: Journal Article
• Language: Japanese
• Published: Japan The Pharmaceutical Society of Japan 01.03.2009
• Subjects: Antineoplastic Agents, Alkylating; antitumor agent; Buffers; Capsules; Dacarbazine - analogs & derivatives; Drug Stability; glioma; Hydrogen-Ion Concentration; Solutions; stability; Temozolomide; Time Factors; Water

We evaluated the stability of temozolomide, an alkylating agent, in solutions after opening the capsule. First, we established an analytical method for determination of temozolomide concentration by HPLC. The calibration curve for temozolomide was linear between 0.5-20 μg/ml (r=0.999). We then evalu...