EFFECT OF PLASTIC BEAD ON GASTRIC CARCINOGENESIS IN RATS TREATED WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE
Experiments were made on induction of cancer of the glandular stomach of rats by a combination of oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and insertion of a plastic bead into the gastric lumen. The incidence of cancer with this combination of treatments was greater th...
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| Published in | GANN Japanese Journal of Cancer Research Vol. 67; no. 2; pp. 197 - 205 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Japanese Cancer Association
01.04.1976
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0016-450X |
| DOI | 10.20772/cancersci1959.67.2_197 |
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| Abstract | Experiments were made on induction of cancer of the glandular stomach of rats by a combination of oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and insertion of a plastic bead into the gastric lumen. The incidence of cancer with this combination of treatments was greater than by administration of MNNG alone. Fluoroscopic examination showed that barium sulfate remained in the stomach longer when a bead had been inserted into the gastric lumen. This indicates that after insertion of a bead, MNNG must have remained in the stomach longer, and so the period of exposure of the gastric mucosa to the carcinogen must have increased. |
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| AbstractList | Experiments were made on induction of cancer of the glandular stomach of rats by a combination of oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and insertion of a plastic bead into the gastric lumen. The incidence of cancer with this combination of treatments was greater than by administration of MNNG alone. Fluoroscopic examination showed that barium sulfate remained in the stomach longer when a bead had been inserted into the gastric lumen. This indicates that after insertion of a bead, MNNG must have remained in the stomach longer, and so the period of exposure of the gastric mucosa to the carcinogen must have increased. Experiments were made on induction of cancer of the glandular stomach of rats by a combination of oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and insertion of a plastic bead into the gastric lumen. The incidence of cancer with this combination of treatments was greater than by administration of MNNG alone. Fluoroscopic examination showed that barium sulfate remained in the stomach longer when a bead had been inserted into the gastric lumen. This indicates that after insertion of a bead, MNNG must have remained in the stomach longer, and so the period of exposure of the gastric mucosa to the carcinogen must have increased.Experiments were made on induction of cancer of the glandular stomach of rats by a combination of oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and insertion of a plastic bead into the gastric lumen. The incidence of cancer with this combination of treatments was greater than by administration of MNNG alone. Fluoroscopic examination showed that barium sulfate remained in the stomach longer when a bead had been inserted into the gastric lumen. This indicates that after insertion of a bead, MNNG must have remained in the stomach longer, and so the period of exposure of the gastric mucosa to the carcinogen must have increased. |
| Author | HANANOUCHI, Motoo TAKAHASHI, Michihito FUKUSHIMA, Shoji SHIRAI, Tomoyuki YOSHIDA, Susumu TATEMATSU, Masae HIROSE, Masao |
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| References | 5) Kananouchi, M., Fukushima, S., Takahashi, M., Gann, 65, 323-330 (1974). 12) Sugimura, T., Fujimura, S., Baba, T., Cancer Res., 30, 455-465 (1970). 6) Ito, M., Yamada, S., Suzuki, H., Nagayo, T., Gann, 60, 223-226 (1969). 2) Fujita, M., Taguchi, T., Takami, M., Usugane, M., Takahashi, A., Shiba, S., Gann, 65, 207-214 (1974). 8) Okajima, E., Hiramatsu, T., Motamiya, Y., Kondo, T., Hirao, Y., Urol. Res., 1, 177-181 (1973). 9) Schoental, R., Nature (London), 209, 726-727 (1966). 10) Shirai, T., Nagoya Med. J., 19, 155-167 (1974). 3) Fukushima, S., Nagoya Med. J., 18, 143-160 (1973). 16) Takahashi, M., Shirai, T., Fukushima, S., Hananouchi, M., Hirose, M., Ito, N., Gann, 67, 47-54 (1976). 4) Fukushima, S., Tatematsu, M., Takahashi, M., Gann, 65, 371-376 (1974). 14) Takahashi, M., Gann, 61, 27-33 (1970). 7) Noguchi, M., Yamada, T., Ichikawa, H., Tanaka, N., Kawachi, T., Kogure, K., Gann, 65, 93-102 (1974). 15) Takahashi, M., Fukushima, S., Sato, H., Gann, 64, 211-218 (1973). 13) Takahashi, M., Sato, H., Gann Monogr., 8, 241-261 (1973). 17) Tatematsu, M., Takahashi, M., Fukushima, S., Hananouchi, M., Shirai, T., J. Natl. Cancer Inst., 55, 101-106 (1975). 1) Fujimura, S., Kogure, K., Sugimura, T., Takayama, S., Cancer Res., 30, 842-848 (1970). 11) Sugimura, T., Fujimura, S., Nature (London), 219, 943-944 (1967). |
| References_xml | – reference: 1) Fujimura, S., Kogure, K., Sugimura, T., Takayama, S., Cancer Res., 30, 842-848 (1970). – reference: 7) Noguchi, M., Yamada, T., Ichikawa, H., Tanaka, N., Kawachi, T., Kogure, K., Gann, 65, 93-102 (1974). – reference: 3) Fukushima, S., Nagoya Med. J., 18, 143-160 (1973). – reference: 4) Fukushima, S., Tatematsu, M., Takahashi, M., Gann, 65, 371-376 (1974). – reference: 5) Kananouchi, M., Fukushima, S., Takahashi, M., Gann, 65, 323-330 (1974). – reference: 9) Schoental, R., Nature (London), 209, 726-727 (1966). – reference: 16) Takahashi, M., Shirai, T., Fukushima, S., Hananouchi, M., Hirose, M., Ito, N., Gann, 67, 47-54 (1976). – reference: 8) Okajima, E., Hiramatsu, T., Motamiya, Y., Kondo, T., Hirao, Y., Urol. Res., 1, 177-181 (1973). – reference: 12) Sugimura, T., Fujimura, S., Baba, T., Cancer Res., 30, 455-465 (1970). – reference: 14) Takahashi, M., Gann, 61, 27-33 (1970). – reference: 10) Shirai, T., Nagoya Med. J., 19, 155-167 (1974). – reference: 13) Takahashi, M., Sato, H., Gann Monogr., 8, 241-261 (1973). – reference: 6) Ito, M., Yamada, S., Suzuki, H., Nagayo, T., Gann, 60, 223-226 (1969). – reference: 15) Takahashi, M., Fukushima, S., Sato, H., Gann, 64, 211-218 (1973). – reference: 17) Tatematsu, M., Takahashi, M., Fukushima, S., Hananouchi, M., Shirai, T., J. Natl. Cancer Inst., 55, 101-106 (1975). – reference: 2) Fujita, M., Taguchi, T., Takami, M., Usugane, M., Takahashi, A., Shiba, S., Gann, 65, 207-214 (1974). – reference: 11) Sugimura, T., Fujimura, S., Nature (London), 219, 943-944 (1967). |
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| SubjectTerms | Adenocarcinoma - chemically induced Adenocarcinoma - pathology Animals Carcinogenesis, chemical Gastric Mucosa - drug effects Male Methacrylate bead Methylnitronitrosoguanidine - administration & dosage Microscopy, Electron N-Methyl-N'-nitro-N-nitrosoguanidine Neoplasms, Experimental - chemically induced Nitrosoguanidines - administration & dosage Physical Stimulation Plastics Rats Sarcoma, Experimental - chemically induced Stomach Neoplasms - chemically induced Stomach Neoplasms - pathology Tumors, glandular stomach Wistar rat |
| Title | EFFECT OF PLASTIC BEAD ON GASTRIC CARCINOGENESIS IN RATS TREATED WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE |
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