Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin

• Published in: Oncology reports Vol. 29; no. 4; pp. 1333 - 1342
• Main Authors: ABE, AKIHISA, KOKUBA, HIROKO
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.04.2013; Spandidos Publications UK Ltd
• Subjects: Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Asthma; Autophagy; Autophagy - drug effects; Brain cancer; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Cancer therapies; Cell cycle; Cell Line, Tumor; Chemotherapy; Cytotoxicity; Down-Regulation; Gene Expression Regulation, Neoplastic - drug effects; Glioma; Glioma - drug therapy; Glioma - genetics; Glioma - pathology; Harmine - analogs & derivatives; Harmine - pharmacology; harmol; Herbal medicine; Homeostasis; Humans; Inhibitor of Apoptosis Proteins - genetics; Inhibitor of Apoptosis Proteins - metabolism; Kinases; mammalian target of rapamycin pathway; Medical prognosis; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; RNA, Small Interfering; Signal Transduction; Studies; survivin; TOR Serine-Threonine Kinases - metabolism; United States > US; Japan

The β-carboline alkaloids are plant substances that exhibit a wide spectrum of neuropharmacological, psychopharmacological and antitumor effects. In the present study, we found that harmol, a β-carboline alkaloid, induced autophagy and suppression of survivin expression, and subsequently induced apo...