circulating cell‐free DNAに着目した周術期フレイル，サルコペニアの病態解明
近年，フレイル，サルコペニアが癌の治療成績に影響するという報告が多く見られる．身体的フレイルの重要な要因がサルコペニアであり，慢性炎症が原因となる．慢性炎症にはDAMPs（Damage‐Associated Molecular Patterns）が関与しており，circulating cell‐free DNA（ccfDNA）もDAMPsの一種であると考えられている．われわれは，ccfDNAの断片化の程度を測定し，周術期サルコペニア，ccfDNAと癌の治療成績の関連を検討した．術後半年後に撮影した腹部CT検査でPMI（Psoas Muscle Index）を測定したところ術後合併症を発症した群...
Saved in:
| Published in | 外科と代謝・栄養 Vol. 57; no. 2; pp. 57 - 61 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本外科代謝栄養学会
15.04.2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0389-5564 2187-5154 |
| DOI | 10.11638/jssmn.57.2_57 |
Cover
Loading…
| Abstract | 近年，フレイル，サルコペニアが癌の治療成績に影響するという報告が多く見られる．身体的フレイルの重要な要因がサルコペニアであり，慢性炎症が原因となる．慢性炎症にはDAMPs（Damage‐Associated Molecular Patterns）が関与しており，circulating cell‐free DNA（ccfDNA）もDAMPsの一種であると考えられている．われわれは，ccfDNAの断片化の程度を測定し，周術期サルコペニア，ccfDNAと癌の治療成績の関連を検討した．術後半年後に撮影した腹部CT検査でPMI（Psoas Muscle Index）を測定したところ術後合併症を発症した群ではPMIが低値で，無再発生存期間が不良であった．また，術前にccfDNA LF（Long Fragment）を認めた症例では無再発生存期間が不良であった．術後合併症を発症しないことが重要であり，そのためにはサルコペニア，慢性炎症への対策が非常に重要であると考えられる． |
|---|---|
| AbstractList | 近年, フレイル, サルコペニアが癌の治療成績に影響するという報告が多く見られる. 身体的フレイルの重要な要因がサルコペニアであり, 慢性炎症が原因となる. 慢性炎症にはDAMPs (Damage-Associated Molecular Patterns)が関与しており, circulating cell-free DNA (ccfDNA)もDAMPsの一種であると考えられている. われわれは, ccfDNAの断片化の程度を測定し, 周術期サルコペニア, ccfDNAと癌の治療成績の関連を検討した. 術後半年後に撮影した腹部CT検査でPMI (Psoas Muscle Index)を測定したところ術後合併症を発症した群ではPMIが低値で, 無再発生存期間が不良であった. また, 術前にccfDNA LF (Long Fragment)を認めた症例では無再発生存期間が不良であった. 術後合併症を発症しないことが重要であり, そのためにはサルコペニア. 慢性炎症への対策が非常に重要であると考えられる. 近年，フレイル，サルコペニアが癌の治療成績に影響するという報告が多く見られる．身体的フレイルの重要な要因がサルコペニアであり，慢性炎症が原因となる．慢性炎症にはDAMPs（Damage‐Associated Molecular Patterns）が関与しており，circulating cell‐free DNA（ccfDNA）もDAMPsの一種であると考えられている．われわれは，ccfDNAの断片化の程度を測定し，周術期サルコペニア，ccfDNAと癌の治療成績の関連を検討した．術後半年後に撮影した腹部CT検査でPMI（Psoas Muscle Index）を測定したところ術後合併症を発症した群ではPMIが低値で，無再発生存期間が不良であった．また，術前にccfDNA LF（Long Fragment）を認めた症例では無再発生存期間が不良であった．術後合併症を発症しないことが重要であり，そのためにはサルコペニア，慢性炎症への対策が非常に重要であると考えられる． |
| Author | 栗山, 翔 松田, 明久 武田, 幸樹 代永, 和秀 進士, 誠一 香中, 伸太郎 吉田, 寛 上田, 康二 山田, 岳史 園田, 寛道 宮坂, 俊光 岩井, 拓磨 |
| Author_xml | – sequence: 1 fullname: 栗山, 翔 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 上田, 康二 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 進士, 誠一 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 香中, 伸太郎 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 武田, 幸樹 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 松田, 明久 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 代永, 和秀 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 吉田, 寛 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 宮坂, 俊光 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 岩井, 拓磨 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 山田, 岳史 organization: 日本医科大学消化器外科 – sequence: 1 fullname: 園田, 寛道 organization: 日本医科大学消化器外科 |
| BookMark | eNo1kE9LG0EYhwdRMMZcPfsFNs68O392LwWxrS2EeqnnYTI7G3fZbMpucujNZMnJUlpKSbEtwVZQiOQi3vw0Dia5-RW6qQov7-8HLzwvPBtoNe2kBqEtguuEcNfbifO8ndaZqINkYgVVgHjCYYTRVVTBruc7jHG6jmp5HjUx86gPwhcVpHWU6V6iulHa2tYmSe6Ov4SZMdsv3-3a_mT--3j-c2r7I9sf33-9XJx9m_0a2-K7La7s4NwWk4fbT3ZwUxY7uLbFqS1O7OCP7U_no-FseLK4-Dv78XkTrYUqyU3tKavo8PWr93tvnMbB_tu93YYTA-fCaQahVjwIQgEAbhgIrsALMMGuCgkNeJOokAOnpKlAUG3AJ55nPACswQit3Craf-S2TRBplXTSJEqNjDu9LC3_yiBmeS9rRRIwuBJjJjCUQf_XcnFCie9SLErSi0dSnHdVy8gPWdRW2Uepsm6kkxK5lF16lkvZy3k-6COVyVi5_wC-PZTr |
| ContentType | Journal Article |
| Copyright | 2023 日本外科代謝栄養学会 |
| Copyright_xml | – notice: 2023 日本外科代謝栄養学会 |
| CorporateAuthor | 日本医科大学消化器外科 |
| CorporateAuthor_xml | – name: 日本医科大学消化器外科 |
| DOI | 10.11638/jssmn.57.2_57 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2187-5154 |
| EndPage | 61 |
| ExternalDocumentID | dj5surgi_2023_005702_004_0057_00614193407 article_jssmn_57_2_57_57_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 MOJWN RJT |
| ID | FETCH-LOGICAL-j2667-bdfca6ddf72223fd76a28d0103af14d6b1af62641ba274ce29188e8220c2e7ca3 |
| ISSN | 0389-5564 |
| IngestDate | Thu Jul 10 16:14:42 EDT 2025 Wed Sep 03 06:30:42 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j2667-bdfca6ddf72223fd76a28d0103af14d6b1af62641ba274ce29188e8220c2e7ca3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jssmn/57/2/57_57/_article/-char/ja |
| PageCount | 5 |
| ParticipantIDs | medicalonline_journals_dj5surgi_2023_005702_004_0057_00614193407 jstage_primary_article_jssmn_57_2_57_57_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 2023/04/15 20230415 |
| PublicationDateYYYYMMDD | 2023-04-15 |
| PublicationDate_xml | – month: 04 year: 2023 text: 2023/04/15 day: 15 |
| PublicationDecade | 2020 |
| PublicationTitle | 外科と代謝・栄養 |
| PublicationTitleAlternate | 外科と代謝・栄養 |
| PublicationYear | 2023 |
| Publisher | 日本外科代謝栄養学会 |
| Publisher_xml | – name: 日本外科代謝栄養学会 |
| References | 6) Cruz‐Jentoft AJ, Baeyens JP, Bauer JM et al.: European Working Group on Sarcopenia in Older People. Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39: 412‐423, 2010 11) Houston DK, Nicklas BJ, Ding J et al.: Dietary protein intake is associated with lean mass change in older, community‐dwelling adults : the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 87: 150‐155, 2008 14) Jiang N, Reich CF 3rd, Pisetsky DS: Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. Blood 102: 2243‐2250, 2003 1) Yuan P, Wu Z, Li Z et al.: Impact of postoperative major complications on long‐term survival after radical resection of gastric cancer. BMC Cancer 19: 833, 2019 15) Krysko DV, Agostinis P, Krysko O et al.: Emerging role of damage‐associated molecular patterns derived from mitochondria in inflammation. Trends Immunol 32: 157‐164, 2011 18) Jounai N, Kobiyama K, Takeshita F et al.: Recognition of damage‐associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol 2: 168, 2013 10) Chen WZ, Chen XD, Ma LL et al.: Impact of Visceral Obesity and Sarcopenia on Short‐Term Outcomes After Colorectal Cancer Surgery. Dig Dis Sci 63: 1620‐1630, 2018 8) Dickinson JM, Volpi E, Rasmussen BB: Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. Exerc Sport Sci Rev 41: 216‐223, 2013 12) Sweegers MG, Altenburg TM, Brug J et al.: Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer : a meta‐analysis of individual patient data. Br J Sports Med 53: 812, 2019 19) Efron PA, Mohr AM, Bihorac A et al.: Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery. Surgery 164: 178‐184, 2018 7) Kanazawa Y, Yamada T, Kakinuma D et al.: Skeletal Muscle Mass Depletion After Gastrectomy Negatively Affects the Prognosis of Patients With Gastric Cancer. Anticancer Res 40: 4271‐4279, 2020 3) 一般社団法人日本老年医学会,国立研究開発法人国立長寿医療研究センター: フレイル診療ガイド 2018年版,ライフ・サイエンス,東京 13) Fiatarone MA, O’Neill EF, Ryan ND et al.: Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330: 1769‐1775, 1994 17) Yanai H, Ban T, Wang Z et al.: HMGB proteins function as universal sentinels for nucleic‐acid‐mediated innate immune responses. Nature 462: 99‐103, 2009 9) Choi MH, Oh SN, Lee IK et al.: Sarcopenia is negatively associated with long‐term outcomes in locally advanced rectal cancer. J Cachexia Sarcopenia Muscle 9: 53‐59, 2018 4) Tan KY, Kawamura YJ, Tokomitsu A et al.: Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg 204: 139‐143, 2012 5) Yamada S, Shimada M, Morine Y et al.: Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma. World J Surg Oncol 19: 94, 2021 16) Jahr S, Hentze H, Englisch S et al.: DNA fragments in the blood plasma of cancer patients : quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61: 1659‐1665, 2001 2) Aoyama T, Oba K, Honda M et al.: Impact of postoperative complications on the colorectal cancer survival and recurrence : analyses of pooled individual patients’ data from three large phase III randomized trials. Cancer Med 6: 1573‐1580, 2017 20) Dos Santos C, Hussain SN, Mathur S et al.: Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study. Am J Respir Crit Care Med 194: 821‐830, 2016 |
| References_xml | – reference: 10) Chen WZ, Chen XD, Ma LL et al.: Impact of Visceral Obesity and Sarcopenia on Short‐Term Outcomes After Colorectal Cancer Surgery. Dig Dis Sci 63: 1620‐1630, 2018 – reference: 6) Cruz‐Jentoft AJ, Baeyens JP, Bauer JM et al.: European Working Group on Sarcopenia in Older People. Sarcopenia : European consensus on definition and diagnosis : Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39: 412‐423, 2010 – reference: 14) Jiang N, Reich CF 3rd, Pisetsky DS: Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. Blood 102: 2243‐2250, 2003 – reference: 5) Yamada S, Shimada M, Morine Y et al.: Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma. World J Surg Oncol 19: 94, 2021 – reference: 1) Yuan P, Wu Z, Li Z et al.: Impact of postoperative major complications on long‐term survival after radical resection of gastric cancer. BMC Cancer 19: 833, 2019 – reference: 11) Houston DK, Nicklas BJ, Ding J et al.: Dietary protein intake is associated with lean mass change in older, community‐dwelling adults : the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 87: 150‐155, 2008 – reference: 2) Aoyama T, Oba K, Honda M et al.: Impact of postoperative complications on the colorectal cancer survival and recurrence : analyses of pooled individual patients’ data from three large phase III randomized trials. Cancer Med 6: 1573‐1580, 2017 – reference: 8) Dickinson JM, Volpi E, Rasmussen BB: Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. Exerc Sport Sci Rev 41: 216‐223, 2013 – reference: 18) Jounai N, Kobiyama K, Takeshita F et al.: Recognition of damage‐associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol 2: 168, 2013 – reference: 9) Choi MH, Oh SN, Lee IK et al.: Sarcopenia is negatively associated with long‐term outcomes in locally advanced rectal cancer. J Cachexia Sarcopenia Muscle 9: 53‐59, 2018 – reference: 19) Efron PA, Mohr AM, Bihorac A et al.: Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery. Surgery 164: 178‐184, 2018 – reference: 15) Krysko DV, Agostinis P, Krysko O et al.: Emerging role of damage‐associated molecular patterns derived from mitochondria in inflammation. Trends Immunol 32: 157‐164, 2011 – reference: 16) Jahr S, Hentze H, Englisch S et al.: DNA fragments in the blood plasma of cancer patients : quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61: 1659‐1665, 2001 – reference: 12) Sweegers MG, Altenburg TM, Brug J et al.: Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer : a meta‐analysis of individual patient data. Br J Sports Med 53: 812, 2019 – reference: 3) 一般社団法人日本老年医学会,国立研究開発法人国立長寿医療研究センター: フレイル診療ガイド 2018年版,ライフ・サイエンス,東京 – reference: 4) Tan KY, Kawamura YJ, Tokomitsu A et al.: Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg 204: 139‐143, 2012 – reference: 7) Kanazawa Y, Yamada T, Kakinuma D et al.: Skeletal Muscle Mass Depletion After Gastrectomy Negatively Affects the Prognosis of Patients With Gastric Cancer. Anticancer Res 40: 4271‐4279, 2020 – reference: 13) Fiatarone MA, O’Neill EF, Ryan ND et al.: Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330: 1769‐1775, 1994 – reference: 20) Dos Santos C, Hussain SN, Mathur S et al.: Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study. Am J Respir Crit Care Med 194: 821‐830, 2016 – reference: 17) Yanai H, Ban T, Wang Z et al.: HMGB proteins function as universal sentinels for nucleic‐acid‐mediated innate immune responses. Nature 462: 99‐103, 2009 |
| SSID | ssib058492797 ssj0003236742 ssib001100176 ssib029852137 |
| Score | 2.3130467 |
| Snippet | 近年，フレイル，サルコペニアが癌の治療成績に影響するという報告が多く見られる．身体的フレイルの重要な要因がサルコペニアであり，慢性炎症が原因となる．慢性炎症にはDAMPs（Damage‐Associated Molecular Patterns）が関与しており，circulating cell‐free... 近年, フレイル, サルコペニアが癌の治療成績に影響するという報告が多く見られる. 身体的フレイルの重要な要因がサルコペニアであり, 慢性炎症が原因となる. 慢性炎症にはDAMPs (Damage-Associated Molecular Patterns)が関与しており, circulating cell-free... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 57 |
| SubjectTerms | ccfDNA サルコペニア フレイル 術後合併症 |
| Title | circulating cell‐free DNAに着目した周術期フレイル，サルコペニアの病態解明 |
| URI | https://www.jstage.jst.go.jp/article/jssmn/57/2/57_57/_article/-char/ja http://mol.medicalonline.jp/library/journal/download?GoodsID=dj5surgi/2023/005702/004&name=0057-0061j |
| Volume | 57 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 外科と代謝・栄養, 2023/04/15, Vol.57(2), pp.57-61 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxRBEB5CvAgiBhXjiz3YJ5l1t-fR0zd7dmcJigEhgdyGeUoWEmU3uXjK7pJTRBSRiA-CD1CI5CLe_DUOJrn5F6zq7slOjIcYWGZru6q7v6mamq7enq4xjBsuiy0ns7iZJ7Fl2rnDzNjLXTNLqRVD_GHbEe4dvjfrzszbdxachYnJqcpTS6srcT15_M99JSexKpSBXXGX7H9Y9qBRKAAa7AtHsDAcj2XjZLGXyNdv4cZZXEAon1zIe1l2sz0rSGBBqEiETwJGeBuZSPhEBJrFWUl0SOAQDsIeCTwioMQigUt4S7JAxiLc0YRoSYISYZcl0EWH-C3ilSzfqbBUiVW2IzThlSxBS6iBRMiI52DvcEQZwMOIUHg84gXVkBphAwzuYkUQg1PQTcGJ2MT3ZUUPMYMGVL9QCE2JBvEAP8fq3sGVrDmoGIf4TfzAZYiN-x3C7bEYtA1YhMQLdEOJQR1BfCbZArQxlueofp9KvFIrUh6ACexPN9eoygs4Xa45oq3kbVQy_FZnDXWxXavUif7_hlq4FKV2sEqPk5oD9TjapGjAo2o7qq2_lSRrtRGYAsJFZSSBqNR0HJUuvp7JMgjtmAnBrF0dClWucO3ytDKuaYaKkFT2_KNjrytT7Xf7_aXlusPqNCxrHcpnrr0llHIgEqIcfkoGbjcMuzDnOUUZk49e3L1fWdnFpGHjEJpyDwLQcYgN8TSnTK-MYzRmYYpCWy0mai3o3K2I99YhtBCFdmFOhsk2ziypdVKVr6YScs6dM87quWJNKMRTxkQ3Om8kFaevodP_XHuG7l4Ddy8G23vv1vbe7BSDzWKw9ev5l_33L3bfbhWjl8XoazH8VIy2f_94Ugy_A1EMvxWj18Vooxh-KAY7e5vru-sb-58_7r56esGY7wRzrRlTvynF7EKADbfXNE8iN01zhuF-njI3ol6Kr3CJ8qadunEzyl2Y-jTjiDI7yShvel4Gc4NGQjOWRNZFY3L54XJ2yajBTT1njLvNLGI2qDfKmBNDHzTL8jRJ3WmDKR2Fj1Q6nPC4Bp02bh9SaqjvpP0w7Tr91d6DxRD9I8T98Q0KX7YkQ5xl2TDPtBvs8ok7v2KcHjvfVWNypbeaXYPpxEp8XV5ffwB1kfD3 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=circulating+cell%E2%80%90free+DNA%E3%81%AB%E7%9D%80%E7%9B%AE%E3%81%97%E3%81%9F%E5%91%A8%E8%A1%93%E6%9C%9F%E3%83%95%E3%83%AC%E3%82%A4%E3%83%AB%EF%BC%8C%E3%82%B5%E3%83%AB%E3%82%B3%E3%83%9A%E3%83%8B%E3%82%A2%E3%81%AE%E7%97%85%E6%85%8B%E8%A7%A3%E6%98%8E&rft.jtitle=%E5%A4%96%E7%A7%91%E3%81%A8%E4%BB%A3%E8%AC%9D%E3%83%BB%E6%A0%84%E9%A4%8A&rft.au=%E6%A0%97%E5%B1%B1%2C+%E7%BF%94&rft.au=%E4%B8%8A%E7%94%B0%2C+%E5%BA%B7%E4%BA%8C&rft.au=%E9%80%B2%E5%A3%AB%2C+%E8%AA%A0%E4%B8%80&rft.au=%E9%A6%99%E4%B8%AD%2C+%E4%BC%B8%E5%A4%AA%E9%83%8E&rft.date=2023-04-15&rft.pub=%E6%97%A5%E6%9C%AC%E5%A4%96%E7%A7%91%E4%BB%A3%E8%AC%9D%E6%A0%84%E9%A4%8A%E5%AD%A6%E4%BC%9A&rft.issn=0389-5564&rft.eissn=2187-5154&rft.volume=57&rft.issue=2&rft.spage=57&rft.epage=61&rft_id=info:doi/10.11638%2Fjssmn.57.2_57&rft.externalDocID=article_jssmn_57_2_57_57_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0389-5564&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0389-5564&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0389-5564&client=summon |