非溶血性輸血副作用を誘導した抗HLA Class II抗体陽性血漿と末梢血単核細胞との反応上清による血管内皮細胞の透過性亢進作用
【背景】非溶血性輸血副作用（nonhemolytic transfusion reactions：NHTRs）の病因において，抗HLA Class II抗体による単球の活性化と，その結果放出される炎症性メディエーターが重要な役割を果たしていると考えられる．また，NHTRsの症状である発疹，蕁麻疹，血管浮腫，肺水腫等の病態には血管透過性の亢進が関与している． 【方法】抗HLA Class II抗体の作用により単球から放出された炎症性メディエーターが血管透過性亢進作用を有するか否かについて検討した．重篤なNHTRsの原因製剤となった抗HLA Class II抗体陽性血漿（抗HLA-DR血漿）とヒト...
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| Published in | 日本輸血細胞治療学会誌 Vol. 56; no. 3; pp. 391 - 399 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本輸血・細胞治療学会
2010
日本輸血・細胞治療学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1881-3011 1883-0625 |
| DOI | 10.3925/jjtc.56.391 |
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| Abstract | 【背景】非溶血性輸血副作用（nonhemolytic transfusion reactions：NHTRs）の病因において，抗HLA Class II抗体による単球の活性化と，その結果放出される炎症性メディエーターが重要な役割を果たしていると考えられる．また，NHTRsの症状である発疹，蕁麻疹，血管浮腫，肺水腫等の病態には血管透過性の亢進が関与している． 【方法】抗HLA Class II抗体の作用により単球から放出された炎症性メディエーターが血管透過性亢進作用を有するか否かについて検討した．重篤なNHTRsの原因製剤となった抗HLA Class II抗体陽性血漿（抗HLA-DR血漿）とヒト末梢血単核細胞（peripheral blood mononuclear cell：PBMNC）とをインキュベートし，得られた反応上清をヒト血管内皮細胞に添加した．デキストラン分子の透過性の変化を測定することにより，血管透過性亢進の有無を評価した． 【結果】抗HLA-DR血漿とPBMNCsを3時間以上インキュベーションして得た反応上清は血管透過性亢進作用を示した．この作用は抗体の特異性に依存していた．反応上清に抗TNF-α中和抗体及び，抗IL-1β中和抗体の両方を添加することにより，血管透過性亢進作用は抑制された．また，TNF-α及びIL-1βにより活性化される転写因子，nuclear factor κB（NF-κB）の阻害剤を血管内皮細胞細胞に作用させることにより，血管透過性亢進は抑制された．一方，アポトーシス阻害剤の影響はみられなかった． 【考察】抗HLA Class II抗体の特異性に依存して単球が活性化され，その結果，産生・放出されたTNF-α及びIL-1βにより血管透過性亢進作用が誘導された．従って，抗HLA Class II抗体による単球の活性化と，その結果放出される炎症性メディエーターが，輸血副作用の発疹，蕁麻疹，血管浮腫及び肺水腫等の病態に関与することが示唆された． |
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| AbstractList | 【背景】非溶血性輸血副作用（nonhemolytic transfusion reactions：NHTRs）の病因において，抗HLA Class II抗体による単球の活性化と，その結果放出される炎症性メディエーターが重要な役割を果たしていると考えられる．また，NHTRsの症状である発疹，蕁麻疹，血管浮腫，肺水腫等の病態には血管透過性の亢進が関与している． 【方法】抗HLA Class II抗体の作用により単球から放出された炎症性メディエーターが血管透過性亢進作用を有するか否かについて検討した．重篤なNHTRsの原因製剤となった抗HLA Class II抗体陽性血漿（抗HLA-DR血漿）とヒト末梢血単核細胞（peripheral blood mononuclear cell：PBMNC）とをインキュベートし，得られた反応上清をヒト血管内皮細胞に添加した．デキストラン分子の透過性の変化を測定することにより，血管透過性亢進の有無を評価した． 【結果】抗HLA-DR血漿とPBMNCsを3時間以上インキュベーションして得た反応上清は血管透過性亢進作用を示した．この作用は抗体の特異性に依存していた．反応上清に抗TNF-α中和抗体及び，抗IL-1β中和抗体の両方を添加することにより，血管透過性亢進作用は抑制された．また，TNF-α及びIL-1βにより活性化される転写因子，nuclear factor κB（NF-κB）の阻害剤を血管内皮細胞細胞に作用させることにより，血管透過性亢進は抑制された．一方，アポトーシス阻害剤の影響はみられなかった． 【考察】抗HLA Class II抗体の特異性に依存して単球が活性化され，その結果，産生・放出されたTNF-α及びIL-1βにより血管透過性亢進作用が誘導された．従って，抗HLA Class II抗体による単球の活性化と，その結果放出される炎症性メディエーターが，輸血副作用の発疹，蕁麻疹，血管浮腫及び肺水腫等の病態に関与することが示唆された． 【背景】非溶血性輸血副作用(nonhemolytic transfusion reactions：NHTRs)の病因において, 抗HLA Class II抗体による単球の活性化と, その結果放出される炎症性メディエーターが重要な役割を果たしていると考えられる. また, NHTRsの症状である発疹, 蕁麻疹, 血管浮腫, 肺水腫等の病態には血管透過性の亢進が関与している. 【方法】抗HLA Class II抗体の作用により単球から放出された炎症性メディエーターが血管透過性亢進作用を有するか否かについて検討した. 重篤なNHTRsの原因製剤となった抗HLA Class II抗体陽性血漿(抗HLA-DR血漿)とヒト末梢血単核細胞(peripheral blood mononuclear cell：PBMNC)とをインキュベートし, 得られた反応上清をヒト血管内皮細胞に添加した. デキストラン分子の透過性の変化を測定することにより, 血管透過性亢進の有無を評価した. 【結果】抗HLA-DR血漿とPBMNCsを3時間以上インキュベーションして得た反応上清は血管透過性亢進作用を示した. この作用は抗体の特異性に依存していた. 反応上清に抗TNF-α中和抗体及び, 抗IL-1β中和抗体の両方を添加することにより, 血管透過性亢進作用は抑制された. また, TNF-α及びIL-1βにより活性化される転写因子, nuclear factor κB(NF-κB)の阻害剤を血管内皮細胞細胞に作用させることにより, 血管透過性亢進は抑制された. 一方, アポトーシス阻害剤の影響はみられなかった. 【考察】抗HLA Class II抗体の特異性に依存して単球が活性化され, その結果, 産生・放出されたTNF-α及びIL-1βにより血管透過性亢進作用が誘導された. 従って, 抗HLA Class II抗体による単球の活性化と, その結果放出される炎症性メディエーターが, 輸血副作用の発疹, 蕁麻疹, 血管浮腫及び肺水腫等の病態に関与することが示唆された. |
| Author | 東, 寛 佐藤, 進一郎 池田, 久實 若本, 志乃舞 藤原, 満博 高橋, 大輔 森岡, 正信 加藤, 俊明 阪川, 久子 丹羽, 光一 |
| Author_FL | NIWA Koichi IKEDA Hisami TAKAHASHI Daisuke SATO Shinichiro FUJIHARA Mitsuhiro WAKAMOTO Shinobu MORIOKA Masanobu KATO Toshiaki AZUMA Hiroshi SAKAGAWA Hisako |
| Author_FL_xml | – sequence: 1 fullname: WAKAMOTO Shinobu – sequence: 2 fullname: FUJIHARA Mitsuhiro – sequence: 3 fullname: SAKAGAWA Hisako – sequence: 4 fullname: TAKAHASHI Daisuke – sequence: 5 fullname: NIWA Koichi – sequence: 6 fullname: MORIOKA Masanobu – sequence: 7 fullname: SATO Shinichiro – sequence: 8 fullname: KATO Toshiaki – sequence: 9 fullname: AZUMA Hiroshi – sequence: 10 fullname: IKEDA Hisami |
| Author_xml | – sequence: 1 fullname: 若本, 志乃舞 organization: 北海道赤十字血液センター – sequence: 1 fullname: 森岡, 正信 organization: 愛育病院 – sequence: 1 fullname: 佐藤, 進一郎 organization: 北海道赤十字血液センター – sequence: 1 fullname: 東, 寛 organization: 北海道赤十字血液センター – sequence: 1 fullname: 高橋, 大輔 organization: 北海道赤十字血液センター – sequence: 1 fullname: 阪川, 久子 organization: 北海道赤十字血液センター – sequence: 1 fullname: 丹羽, 光一 organization: 東京農業大学生物産業学部 食品科学科 – sequence: 1 fullname: 藤原, 満博 organization: 北海道赤十字血液センター – sequence: 1 fullname: 池田, 久實 organization: 北海道赤十字血液センター – sequence: 1 fullname: 加藤, 俊明 organization: 北海道赤十字血液センター |
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| References | 28) Fukumoto T, Matsukawa A, Yoshimura T, et al: IL-8 is an essential mediator of the increased delayed-phase vascular permeability in LPS-induced rabbit pleurisy. J. Leukoc. Biol., 63: 584-590, 1998. 17) Sachs UJ, Hattar K, Weissmann N, et al: Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood, 107: 1217-1219, 2006. 20) Silliman CC, Curtis BR, Kopko PM, et al: Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood, 109: 1752-1755, 2007. 1) Mehta D, Malik AB: Signaling mechanisms regulating endothelial permeability. Physiol. Rev., 86: 279-367, 2006. 16) Seeger W, Schneider U, Kreusler B, et al: Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood, 76: 1438-1444, 1990. 37) Beck GC, Yard BA, Breedijk AJ, et al: Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells. Clin. Exp. Immunol., 118: 298-303, 1999. 33) Pohlman TH, Harlan JM: Human endothelial cell response to lipopolysaccharide, interleukin-1, and tumor necrosis factor is regulated by protein synthesis. Cell. Immunol., 119: 41-52, 1989. 32) Wallach D: Cell death induction by TNF: a matter of self control. Trends. Biochem. Sci., 22: 107-109, 1997. 12) Wallis JP, Lubenko A, Wells AW, et al: Single hospital experience of TRALI. Transfusion, 43: 1053-1059, 2003. 31) Stefanec T: Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest, 117: 841-854, 2000. 22) Nishimura M, Hashimoto S, Satake M, et al: Interference with TRALI-causing anti-HLA DR alloantibody induction of human pulmonary microvascular endothelial cell injury by purified soluble HLA DR. Vox Sang., 93: 78-82, 2007. 6) Van Buren NL, Stroncek DF, Clay ME, et al: Transfusion-related acute lung injury caused by an NB2 granulocyte-specific antibody in a patient with thrombotic thrombocytopenic purpura. Transfusion, 30: 42-45, 1990. 40) Otto M, Bittinger F, Kriegsmann J, et al: Differential adhesion of polymorphous neutrophilic granulocytes to macro- and microvascular endothelial cells under flow conditions. Pathobiology, 69: 159-171, 2001. 26) Sakagawa H, Miyazaki T, Fujihara M, et al: Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA Class II antibody-containing plasma unit that was associated with severe nonhemolytic transfusion reactions. Transfusion, 47: 154-161, 2007. 21) Nishimura M, Hashimoto S, Takanashi M, et al: Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injury. Transfus. Med., 17: 129-134, 2007. 38) Burg J, Krump-Konvalinkova V, Bittinger F, et al: GM-CSF expression by human lung microvascular endothelial cells: in vitro and in vivo findings. Am. J. Physiol. Lung.Cell. Mol. Physiol., 283: L460-467, 2002. 34) Madge LA, Li JH, Choi J, et al: Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis. J Biol Chem, 278: 21295-21306, 2003. 36) Xia P, Wang L, Gamble JR, et al: Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J. Biol. Chem., 274: 34499-34505, 1999. 39) Hillyer P, Mordelet E, Flynn G, et al: Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration. Clin. Exp. Immunol., 134: 431-441, 2003. 29) Sedgwick JB, Menon I, Gern JE, et al: Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration. J. Allergy. Clin. Immunol., 110: 752-756, 2002. 41) Shelton JL, Wang L, Cepinskas G, et al: Albumin leak across human pulmonary microvascular vs. umbilical vein endothelial cells under septic conditions. Microvasc. Res., 71: 40-47, 2006. 19) Khan SY, Kelher MR, Heal JM, et al: Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood, 108: 2455-2462, 2006. 24) Nooteboom A, Bleichrodt RP, Hendriks T: Modulation of endothelial monolayer permeability induced by plasma obtained from lipopolysaccharide-stimulated whole blood. Clin. Exp. Immunol., 144: 362-369, 2006. 23) Nooteboom A, Van Der Linden CJ, Hendriks T: Tumor necrosis factor-alpha and interleukin-1beta mediate endothelial permeability induced by lipopolysaccharide-stimulated whole blood. Crit. Care. Med., 30: 2063-2068, 2002. 27) Maruo N, Morita I, Shirao M, et al: IL-6 increases endothelial permeability in vitro. Endocrinology, 131: 710-714, 1992. 5) Bux J, Sachs UJ: The pathogenesis of transfusion-related acute lung injury (TRALI). Br. J. Haematol., 136: 788-799, 2007. 15) Kopko PM, Paglieroni TG, Popovsky MA, et al: TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion, 43: 177-184, 2003. 30) Ferrari G, Yan CY, Greene LA: N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci., 15: 2857-2866, 1995. 14) Silliman CC, Ambruso DR, Boshkov LK: Transfusion-related acute lung injury. Blood, 105: 2266-2273, 2005. 9) Kopko PM, Popovsky MA, MacKenzie MR, et al: HLA class II antibodies in transfusion-related acute lung injury. Transfusion, 41: 1244-1248, 2001. 11) Kao GS, Wood IG, Dorfman DM, et al: Investigations into the role of anti-HLA class II antibodies in TRALI. Transfusion, 43: 185-191, 2003. 3) Popovsky MA, Moore SB: Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion, 25: 573-577, 1985. 42) Furuhata S, Ando K, Oki M, et al: Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis. Mol. Cell. Biochem., 298: 125-138, 2007. 2) Geiger TL, Howard SC: Acetaminophen and diphenhydramine premedication for allergic and febrile nonhemolytic transfusion reactions: good prophylaxis or bad practice? Transfus. Med. Rev., 21: 1-12, 2007. 10) Flesch BK, Neppert J: Transfusion-related acute lung injury caused by human leucocyte antigen class II antibody. Br. J. Haematol., 116: 673-676, 2002. 13) Nicolle AL, Chapman CE, Carter V, et al: Transfusion-related acute lung injury caused by two donors with anti-human leucocyte antigen class II antibodies: a look-back investigation. Transfus. Med., 14: 225-230, 2004. 4) Holness L, Knippen MA, Simmons L, et al: Fatalities caused by TRALI. Transfus. Med. Rev., 18: 184-188, 2004. 8) Kopko PM, Marshall CS, MacKenzie MR, et al: Transfusion-related acute lung injury: report of a clinical look-back investigation. JAMA, 287: 1968-1971, 2002. 7) Davoren A, Smith OP, Barnes CA, et al: Case report: four donors with granulocyte-specific or HLA class I antibodies implicated in a case of transfusion-related acute lung injury (TRALI). Immunohematol., 17: 117-121, 2001. 35) Madge LA, Pober JS: A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF-κB in human endothelial cells. J. Biol. Chem., 275: 15458-15465, 2000. 18) Wyman TH, Bjornsen AJ, Elzi DJ, et al: A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release. Am. J. Physiol. Cell. Physiol., 283: C1592-1603, 2002. 25) Burke-Gaffney A, Keenan AK: Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 α/β, tumor necrosis factor-alpha and interferon-γ. Immunopharmacology, 25: 1-9, 1993. |
| References_xml | – reference: 35) Madge LA, Pober JS: A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF-κB in human endothelial cells. J. Biol. Chem., 275: 15458-15465, 2000. – reference: 31) Stefanec T: Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest, 117: 841-854, 2000. – reference: 5) Bux J, Sachs UJ: The pathogenesis of transfusion-related acute lung injury (TRALI). Br. J. Haematol., 136: 788-799, 2007. – reference: 2) Geiger TL, Howard SC: Acetaminophen and diphenhydramine premedication for allergic and febrile nonhemolytic transfusion reactions: good prophylaxis or bad practice? Transfus. Med. Rev., 21: 1-12, 2007. – reference: 20) Silliman CC, Curtis BR, Kopko PM, et al: Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood, 109: 1752-1755, 2007. – reference: 30) Ferrari G, Yan CY, Greene LA: N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci., 15: 2857-2866, 1995. – reference: 10) Flesch BK, Neppert J: Transfusion-related acute lung injury caused by human leucocyte antigen class II antibody. Br. J. Haematol., 116: 673-676, 2002. – reference: 15) Kopko PM, Paglieroni TG, Popovsky MA, et al: TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion, 43: 177-184, 2003. – reference: 22) Nishimura M, Hashimoto S, Satake M, et al: Interference with TRALI-causing anti-HLA DR alloantibody induction of human pulmonary microvascular endothelial cell injury by purified soluble HLA DR. Vox Sang., 93: 78-82, 2007. – reference: 37) Beck GC, Yard BA, Breedijk AJ, et al: Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells. Clin. Exp. Immunol., 118: 298-303, 1999. – reference: 26) Sakagawa H, Miyazaki T, Fujihara M, et al: Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA Class II antibody-containing plasma unit that was associated with severe nonhemolytic transfusion reactions. Transfusion, 47: 154-161, 2007. – reference: 8) Kopko PM, Marshall CS, MacKenzie MR, et al: Transfusion-related acute lung injury: report of a clinical look-back investigation. JAMA, 287: 1968-1971, 2002. – reference: 13) Nicolle AL, Chapman CE, Carter V, et al: Transfusion-related acute lung injury caused by two donors with anti-human leucocyte antigen class II antibodies: a look-back investigation. Transfus. Med., 14: 225-230, 2004. – reference: 25) Burke-Gaffney A, Keenan AK: Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 α/β, tumor necrosis factor-alpha and interferon-γ. Immunopharmacology, 25: 1-9, 1993. – reference: 40) Otto M, Bittinger F, Kriegsmann J, et al: Differential adhesion of polymorphous neutrophilic granulocytes to macro- and microvascular endothelial cells under flow conditions. Pathobiology, 69: 159-171, 2001. – reference: 28) Fukumoto T, Matsukawa A, Yoshimura T, et al: IL-8 is an essential mediator of the increased delayed-phase vascular permeability in LPS-induced rabbit pleurisy. J. Leukoc. Biol., 63: 584-590, 1998. – reference: 24) Nooteboom A, Bleichrodt RP, Hendriks T: Modulation of endothelial monolayer permeability induced by plasma obtained from lipopolysaccharide-stimulated whole blood. Clin. Exp. Immunol., 144: 362-369, 2006. – reference: 3) Popovsky MA, Moore SB: Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion, 25: 573-577, 1985. – reference: 39) Hillyer P, Mordelet E, Flynn G, et al: Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration. Clin. Exp. Immunol., 134: 431-441, 2003. – reference: 29) Sedgwick JB, Menon I, Gern JE, et al: Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration. J. Allergy. Clin. Immunol., 110: 752-756, 2002. – reference: 6) Van Buren NL, Stroncek DF, Clay ME, et al: Transfusion-related acute lung injury caused by an NB2 granulocyte-specific antibody in a patient with thrombotic thrombocytopenic purpura. Transfusion, 30: 42-45, 1990. – reference: 11) Kao GS, Wood IG, Dorfman DM, et al: Investigations into the role of anti-HLA class II antibodies in TRALI. Transfusion, 43: 185-191, 2003. – reference: 4) Holness L, Knippen MA, Simmons L, et al: Fatalities caused by TRALI. Transfus. Med. Rev., 18: 184-188, 2004. – reference: 17) Sachs UJ, Hattar K, Weissmann N, et al: Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood, 107: 1217-1219, 2006. – reference: 38) Burg J, Krump-Konvalinkova V, Bittinger F, et al: GM-CSF expression by human lung microvascular endothelial cells: in vitro and in vivo findings. Am. J. Physiol. Lung.Cell. Mol. Physiol., 283: L460-467, 2002. – reference: 33) Pohlman TH, Harlan JM: Human endothelial cell response to lipopolysaccharide, interleukin-1, and tumor necrosis factor is regulated by protein synthesis. Cell. Immunol., 119: 41-52, 1989. – reference: 19) Khan SY, Kelher MR, Heal JM, et al: Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood, 108: 2455-2462, 2006. – reference: 36) Xia P, Wang L, Gamble JR, et al: Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J. Biol. Chem., 274: 34499-34505, 1999. – reference: 42) Furuhata S, Ando K, Oki M, et al: Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis. Mol. Cell. Biochem., 298: 125-138, 2007. – reference: 7) Davoren A, Smith OP, Barnes CA, et al: Case report: four donors with granulocyte-specific or HLA class I antibodies implicated in a case of transfusion-related acute lung injury (TRALI). Immunohematol., 17: 117-121, 2001. – reference: 18) Wyman TH, Bjornsen AJ, Elzi DJ, et al: A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release. Am. J. Physiol. Cell. Physiol., 283: C1592-1603, 2002. – reference: 23) Nooteboom A, Van Der Linden CJ, Hendriks T: Tumor necrosis factor-alpha and interleukin-1beta mediate endothelial permeability induced by lipopolysaccharide-stimulated whole blood. Crit. Care. Med., 30: 2063-2068, 2002. – reference: 12) Wallis JP, Lubenko A, Wells AW, et al: Single hospital experience of TRALI. Transfusion, 43: 1053-1059, 2003. – reference: 34) Madge LA, Li JH, Choi J, et al: Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis. J Biol Chem, 278: 21295-21306, 2003. – reference: 14) Silliman CC, Ambruso DR, Boshkov LK: Transfusion-related acute lung injury. Blood, 105: 2266-2273, 2005. – reference: 32) Wallach D: Cell death induction by TNF: a matter of self control. Trends. Biochem. Sci., 22: 107-109, 1997. – reference: 1) Mehta D, Malik AB: Signaling mechanisms regulating endothelial permeability. Physiol. Rev., 86: 279-367, 2006. – reference: 27) Maruo N, Morita I, Shirao M, et al: IL-6 increases endothelial permeability in vitro. Endocrinology, 131: 710-714, 1992. – reference: 16) Seeger W, Schneider U, Kreusler B, et al: Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood, 76: 1438-1444, 1990. – reference: 21) Nishimura M, Hashimoto S, Takanashi M, et al: Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injury. Transfus. Med., 17: 129-134, 2007. – reference: 9) Kopko PM, Popovsky MA, MacKenzie MR, et al: HLA class II antibodies in transfusion-related acute lung injury. Transfusion, 41: 1244-1248, 2001. – reference: 41) Shelton JL, Wang L, Cepinskas G, et al: Albumin leak across human pulmonary microvascular vs. umbilical vein endothelial cells under septic conditions. Microvasc. Res., 71: 40-47, 2006. |
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| Snippet | 【背景】非溶血性輸血副作用（nonhemolytic transfusion reactions：NHTRs）の病因において，抗HLA Class... 【背景】非溶血性輸血副作用(nonhemolytic transfusion reactions：NHTRs)の病因において, 抗HLA Class II抗体による単球の活性化と, その結果放出される炎症性メディエーターが重要な役割を果たしていると考えられる. また, NHTRsの症状である発疹, 蕁麻疹,... |
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| SubjectTerms | activation of PBMNCs anti-HLA Class II antibody increase in EC permeability nonhemolytic transfusion reactions ヒト末梢血単核細胞の活性化 抗 HLA Class II 抗体 抗HLA Class II抗体 血管内皮細胞の透過性亢進 非溶血性輸血副作用 |
| Title | 非溶血性輸血副作用を誘導した抗HLA Class II抗体陽性血漿と末梢血単核細胞との反応上清による血管内皮細胞の透過性亢進作用 |
| URI | https://www.jstage.jst.go.jp/article/jjtc/56/3/56_3_391/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=cc5trcel/2010/005603/008&name=0391-0399j https://cir.nii.ac.jp/crid/1573668926003272832 |
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| ispartofPNX | 日本輸血細胞治療学会誌, 2010, Vol.56(3), pp.391-399 |
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