Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin
To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and s...
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| Published in | Nano Biomedicine Vol. 9; no. 2; pp. 69 - 76 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Nano Biomedical Society
30.12.2017
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| Abstract | To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects.Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering. |
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| AbstractList | To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects.Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering. |
| Author | FUJII, Syuji MIYAJI, Hirofumi KAWAMOTO, Kohei SHITOMI, Kanako FURIHATA, Tomokazu TATEYAMA, Akito SUGAYA, Tsutomu KATO, Akihito IWASAKI, Yasuhiko MAYUMI, Kayoko NISHIDA, Erika |
| Author_xml | – sequence: 1 fullname: TATEYAMA, Akito organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 2 fullname: KATO, Akihito organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 3 fullname: MIYAJI, Hirofumi organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 4 fullname: NISHIDA, Erika organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 5 fullname: IWASAKI, Yasuhiko organization: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan – sequence: 6 fullname: FUJII, Syuji organization: Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, Osaka, Japan – sequence: 7 fullname: KAWAMOTO, Kohei organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 8 fullname: SHITOMI, Kanako organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 9 fullname: FURIHATA, Tomokazu organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 10 fullname: MAYUMI, Kayoko organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan – sequence: 11 fullname: SUGAYA, Tsutomu organization: Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan |
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| Title | Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin |
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