ALSの臨床, 病態と治療
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| Published in | 脊髄外科 Vol. 26; no. 3; pp. 270 - 277 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本脊髄外科学会
2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0914-6024 1880-9359 |
| DOI | 10.2531/spinalsurg.26.270 |
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| Author | 阿部, 康二 |
|---|---|
| Author_FL | ABE Koji |
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| Author_xml | – sequence: 1 fullname: 阿部, 康二 organization: 岡山大学大学院医歯薬学総合研究科脳神経内科学 |
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| DocumentTitleAlternate | Clinical Features, Pathogenesis, and Therapy for ALS |
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| References | 14) Yoshino H, Kimura A : Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase Ⅱ study). ALS 7 : 241-245, 2006 13) Abe K, Yuki S, Kogure K : Strong attenuation of ischemic and postischemic brain edema by a novel free radical scavenger. Stroke 19 : 480-485, 1988 21) Habisch HJ, Janowski M, Binder D, et al : Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS : limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm 114 : 1395-1406, 2007 6) Nagai M, Re DB, Nagata T, et al : Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 10 : 615-622, 2007 20) Suzuki M, McHugh J, Tork C, et al : GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS ONE 2 : e689, 2007 3) Urushitani M, Ezzi SA, Matsuo A, et al : The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS. FASEB J 22 : 2476-2487, 2008 16) Mazzini L, Mareschi K, Ferrero I, et al : Autologous mesenchymal stem cells : clinical applications in amyotrophic lateral sclerosis. Neurol Res 28 : 523-526, 2006 5) Urushitani M, Sik A, Sakurai T, et al : Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci 9 : 108-118, 2006 22) Suzuki M, Svendsen CN : Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci 31 : 192-198, 2008 4) Miyazaki K, Masamoto K, Morimoto N, et al : Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice. J Cereb Blood Flow Metab 32 : 456-467, 2012 12) Nagano I, Shiote M, Murakami T, et al : Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis. Neurol Res 27 : 768-772, 2005 18) Yan J, Xu L, Welsh AM, et al : Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice. Stem Cells 24 : 1976-1985, 2006 10) Tian F, Morimoto N, Liu W, et al : In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis. Autophagy 7 : 985-992, 2011 8) Yamanaka K, Boillee S, Roberts EA, et al : Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci USA 105 : 7594-7599, 2008 7) Yamanaka K, Chun SJ, Boillee S, et al : Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11 : 251-253, 2008 19) Zhao CP, Zhang C, Zhou SN, et al : Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice. Cytotherapy 9 : 414-426, 2007 1) Nagata T, Nagano I, Shiote M, et al : Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of ALS patients. Neurol Res 29 : 772-776, 2007 2) Nagata T, Ilieva H, Murakami T, et al : Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Neurol Res 29 : 767-771, 2007 9) Morimoto N, Nagai M, Ohta Y, et al : Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res 1167 : 112-117, 2007 17) Mazzini L, Mareschi K, Ferrero I, et al : Stem cell treatment in amyotrophic lateral sclerosis. J Neurol Sci 265 : 78-83, 2008 11) Nagano I, Ilieva H, Shiote M, et al : Therapeutic benefit of intrathecalinjection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis. J Neurol Sci 235 : 61-68, 2005 15) Ohta Y, Nagai M, Nagata T, et al : Intrathecal injection of EGF and FGF2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene. J Neurosci Res 84 : 980-982, 2006 |
| References_xml | – reference: 2) Nagata T, Ilieva H, Murakami T, et al : Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Neurol Res 29 : 767-771, 2007 – reference: 14) Yoshino H, Kimura A : Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase Ⅱ study). ALS 7 : 241-245, 2006 – reference: 7) Yamanaka K, Chun SJ, Boillee S, et al : Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11 : 251-253, 2008 – reference: 4) Miyazaki K, Masamoto K, Morimoto N, et al : Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice. J Cereb Blood Flow Metab 32 : 456-467, 2012 – reference: 20) Suzuki M, McHugh J, Tork C, et al : GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS ONE 2 : e689, 2007 – reference: 10) Tian F, Morimoto N, Liu W, et al : In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis. Autophagy 7 : 985-992, 2011 – reference: 9) Morimoto N, Nagai M, Ohta Y, et al : Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res 1167 : 112-117, 2007 – reference: 22) Suzuki M, Svendsen CN : Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci 31 : 192-198, 2008 – reference: 5) Urushitani M, Sik A, Sakurai T, et al : Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci 9 : 108-118, 2006 – reference: 13) Abe K, Yuki S, Kogure K : Strong attenuation of ischemic and postischemic brain edema by a novel free radical scavenger. Stroke 19 : 480-485, 1988 – reference: 8) Yamanaka K, Boillee S, Roberts EA, et al : Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci USA 105 : 7594-7599, 2008 – reference: 15) Ohta Y, Nagai M, Nagata T, et al : Intrathecal injection of EGF and FGF2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene. J Neurosci Res 84 : 980-982, 2006 – reference: 12) Nagano I, Shiote M, Murakami T, et al : Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis. Neurol Res 27 : 768-772, 2005 – reference: 19) Zhao CP, Zhang C, Zhou SN, et al : Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice. Cytotherapy 9 : 414-426, 2007 – reference: 11) Nagano I, Ilieva H, Shiote M, et al : Therapeutic benefit of intrathecalinjection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis. J Neurol Sci 235 : 61-68, 2005 – reference: 1) Nagata T, Nagano I, Shiote M, et al : Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of ALS patients. Neurol Res 29 : 772-776, 2007 – reference: 17) Mazzini L, Mareschi K, Ferrero I, et al : Stem cell treatment in amyotrophic lateral sclerosis. J Neurol Sci 265 : 78-83, 2008 – reference: 6) Nagai M, Re DB, Nagata T, et al : Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 10 : 615-622, 2007 – reference: 18) Yan J, Xu L, Welsh AM, et al : Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice. Stem Cells 24 : 1976-1985, 2006 – reference: 16) Mazzini L, Mareschi K, Ferrero I, et al : Autologous mesenchymal stem cells : clinical applications in amyotrophic lateral sclerosis. Neurol Res 28 : 523-526, 2006 – reference: 21) Habisch HJ, Janowski M, Binder D, et al : Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS : limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm 114 : 1395-1406, 2007 – reference: 3) Urushitani M, Ezzi SA, Matsuo A, et al : The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS. FASEB J 22 : 2476-2487, 2008 |
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| Title | ALSの臨床, 病態と治療 |
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