Post-chemotherapy intestinal fibrotic stricture in a cat with high-grade intestinal lymphoma a case report
A 3-year-old castrated male cat was presented with lethargy, anorexia, and melena. A complete blood count revealed regenerative anemia. Abdominal ultrasonography revealed a layer-disrupted intestinal mass at the ileocecal junction. Fine needle aspiration performed on the mass revealed large lymphocy...
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| Published in | Japanese Journal of Veterinary Research Vol. 73; no. 1; pp. 22 - 26 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japanese Journal of Veterinary Research Editorial Committee
27.03.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0047-1917 2758-447X |
| DOI | 10.57494/jjvr.73.1_22 |
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| Abstract | A 3-year-old castrated male cat was presented with lethargy, anorexia, and melena. A complete blood count revealed regenerative anemia. Abdominal ultrasonography revealed a layer-disrupted intestinal mass at the ileocecal junction. Fine needle aspiration performed on the mass revealed large lymphocytes, suggesting lymphoma. The patient was treated with CHOP-based chemotherapy but admitted for emergency care with vomiting and depression during the CHOP protocol. Abdominal ultrasonography suggested annular intestinal stricture at the site of lymphoma. The patient underwent ileocecectomy, which resolved the small intestinal obstruction. Histopathologic examination of the resected specimen demonstrated transmural enterotyphilitis with prominent fibrosis. The patient remained stable without relapse. To our knowledge, this is the first case of intestinal stricture occurring during chemotherapy for feline high-grade intestinal lymphoma. |
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| AbstractList | A 3-year-old castrated male cat was presented with lethargy, anorexia, and melena. A complete blood count revealed regenerative anemia. Abdominal ultrasonography revealed a layer-disrupted intestinal mass at the ileocecal junction. Fine needle aspiration performed on the mass revealed large lymphocytes, suggesting lymphoma. The patient was treated with CHOP-based chemotherapy but admitted for emergency care with vomiting and depression during the CHOP protocol. Abdominal ultrasonography suggested annular intestinal stricture at the site of lymphoma. The patient underwent ileocecectomy, which resolved the small intestinal obstruction. Histopathologic examination of the resected specimen demonstrated transmural enterotyphilitis with prominent fibrosis. The patient remained stable without relapse. To our knowledge, this is the first case of intestinal stricture occurring during chemotherapy for feline high-grade intestinal lymphoma. |
| Author | Yun, Youngmin Song, Woo-Jin Lee, JeongHa Lee, Siheon Kim, Myung-Chul Yoon, Jiwoong Hong, Hyun Jeong Hong, Yeon-jung Park, Jung-Hoon |
| Author_xml | – sequence: 1 fullname: Lee, Siheon organization: 24hr WISE Animal Medical Center – sequence: 1 fullname: Park, Jung-Hoon organization: Western Referral Animal Medical Center – sequence: 1 fullname: Lee, JeongHa organization: Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University – sequence: 1 fullname: Kim, Myung-Chul organization: The Research Institute of Veterinary Science, College of Veterinary Medicine, Jeju National University – sequence: 1 fullname: Song, Woo-Jin organization: The Research Institute of Veterinary Science, College of Veterinary Medicine, Jeju National University – sequence: 1 fullname: Hong, Hyun Jeong organization: Western Referral Animal Medical Center – sequence: 1 fullname: Hong, Yeon-jung organization: Western Referral Animal Medical Center – sequence: 1 fullname: Yoon, Jiwoong organization: Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University – sequence: 1 fullname: Yun, Youngmin organization: Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University |
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| References | 11) Tumielewicz KL, Hudak D, Kim J, Hunley DW, Murphy LA. Review of oncological emergencies in small animal patients. Vet Med Sci 5, 271–296, 2019. doi: 10.1002/vms3.164. 4) He Z, Zhang S. Tumor-associated macrophages and their functional transformation in the hypoxic tumor microenvironment. Front Immunol 12, 741305, 2021. doi: 10.3389/fimmu.2021.741305. 13) Wang X, Li J-Z, Yang Y-H, Huang X-L, Wang Y, Wu B. Intestinal atresia following chemotherapy, presenting as superior mesenteric artery syndrome: A case report. Mol Clin Oncol 7, 543–546, 2017. doi: 10.3892/mco.2017.1353. 2) Bernardo Marques G, Ponce F, Beaudu-Lange C, Béguin J, Boissy L, Chavalle T, Denoeux P, Diop N, Ferro L, Floch F, Lajoinie M, Sayag D, Barrett LE, Chamel G. Feline high-grade and large granular lymphocyte alimentary lymphomas treated with COP- or CHOP-based chemotherapy: A multi-centric retrospective study of 57 cases. Vet Comp Oncol 22, 186–197, 2024. doi: 10.1111/vco.12965. 1) Ben Abdallah K, Ben Mohamed A, Yacoubi M, Khsiba A, Dougaz A, Chelbi E, Hamzaoui L. Post-chemotherapy gastric obstruction in diffuse large B-cell lymphoma: Endoscopic dilation can fix it! Case Rep Gastroenterol 16, 301–307, 2022. doi: 10.1159/000524497. 12) Vail DM, Michels GM, Khanna C, Selting KA, London CA, Veterinary Cooperative Oncology Group. Response evaluation criteria for peripheral nodal lymphoma in dogs (v1.0)–a veterinary cooperative oncology group (VCOG) consensus document. Vet Comp Oncol 8, 28–37, 2010. doi: 10.1111/j.1476-5829.2009.00200.x. 15) Zhao JF, Ling FM, Li JR, Chen YD, Huang L, Zhu LR. Role of non-inflammatory factors in intestinal fibrosis. J Dig Dis 21, 315–318, 2020. doi: 10.1111/1751-2980.12883. 9) Simon D, Eberle N, Laacke-Singer L, Nolte I. Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, and duration in 23 cats. J Vet Intern Med 22, 394–400, 2008. doi: 10.1111/j.1939-1676.2008.0057.x. 14) Xin S, Liu X, He C, Gao H, Wang B, Hua R, Gao L, Shang H, Sun F, Xu J. Inflammation accelerating intestinal fibrosis: from mechanism to clinic. Eur J Med Res 29, 335, 2024. doi: 10.1186/s40001-024-01932-2. 3) Gouldin ED, Mullin C, Morges M, Mehler SJ, de Lorimier L-P, Oakley C, Risbon R, May L, Kahn SA, Clifford C. Feline discrete high-grade gastrointestinal lymphoma treated with surgical resection and adjuvant CHOP-based chemotherapy: retrospective study of 20 cases. Vet Comp Oncol 15, 328–335, 2017. doi: 10.1111/vco.12166. 5) Holloway A, Pivetta M, Rasotto R. Ultrasonographic and histopathological features in 8 cats with fibrotic small intestinal stricture. Vet Radiol Ultrasound 60, 423–431, 2019. doi: 10.1111/vru.12756. 8) Mancini ML, Sonis ST. Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities. Front Pharmacol 5, 51, 2014. doi: 10.3389/fphar.2014.00051. 10) Tan IJ-W, Tan K-K. A rare case of ileocecal valve stricture. Gastroenterology 159, e14–e15, 2020. doi: 10.1053/j.gastro.2020.04.024. 7) Kwak D-H, Cho M-J, Park H-J, Song K-H, Seo K-W. A retrospective study of 16 cats with intermediate- to high-grade alimentary lymphoma. Korean journal of veterinary research 61, e8, 2021. doi :10.14405/kjvr.2021.61.e8. 6) Honzawa Y, Kondo M, Hayakumo T, Matsuura M, Nakase H. Successful endoscopic dilation treatment of small intestinal stricture occurring during chemotherapy for malignant lymphoma. Case Rep Gastroenterol 4, 323–329, 2010. doi: 10.1159/000320538. |
| References_xml | – reference: 13) Wang X, Li J-Z, Yang Y-H, Huang X-L, Wang Y, Wu B. Intestinal atresia following chemotherapy, presenting as superior mesenteric artery syndrome: A case report. Mol Clin Oncol 7, 543–546, 2017. doi: 10.3892/mco.2017.1353. – reference: 1) Ben Abdallah K, Ben Mohamed A, Yacoubi M, Khsiba A, Dougaz A, Chelbi E, Hamzaoui L. Post-chemotherapy gastric obstruction in diffuse large B-cell lymphoma: Endoscopic dilation can fix it! Case Rep Gastroenterol 16, 301–307, 2022. doi: 10.1159/000524497. – reference: 5) Holloway A, Pivetta M, Rasotto R. Ultrasonographic and histopathological features in 8 cats with fibrotic small intestinal stricture. Vet Radiol Ultrasound 60, 423–431, 2019. doi: 10.1111/vru.12756. – reference: 15) Zhao JF, Ling FM, Li JR, Chen YD, Huang L, Zhu LR. Role of non-inflammatory factors in intestinal fibrosis. J Dig Dis 21, 315–318, 2020. doi: 10.1111/1751-2980.12883. – reference: 12) Vail DM, Michels GM, Khanna C, Selting KA, London CA, Veterinary Cooperative Oncology Group. Response evaluation criteria for peripheral nodal lymphoma in dogs (v1.0)–a veterinary cooperative oncology group (VCOG) consensus document. Vet Comp Oncol 8, 28–37, 2010. doi: 10.1111/j.1476-5829.2009.00200.x. – reference: 9) Simon D, Eberle N, Laacke-Singer L, Nolte I. Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, and duration in 23 cats. J Vet Intern Med 22, 394–400, 2008. doi: 10.1111/j.1939-1676.2008.0057.x. – reference: 11) Tumielewicz KL, Hudak D, Kim J, Hunley DW, Murphy LA. Review of oncological emergencies in small animal patients. Vet Med Sci 5, 271–296, 2019. doi: 10.1002/vms3.164. – reference: 14) Xin S, Liu X, He C, Gao H, Wang B, Hua R, Gao L, Shang H, Sun F, Xu J. Inflammation accelerating intestinal fibrosis: from mechanism to clinic. Eur J Med Res 29, 335, 2024. doi: 10.1186/s40001-024-01932-2. – reference: 6) Honzawa Y, Kondo M, Hayakumo T, Matsuura M, Nakase H. Successful endoscopic dilation treatment of small intestinal stricture occurring during chemotherapy for malignant lymphoma. Case Rep Gastroenterol 4, 323–329, 2010. doi: 10.1159/000320538. – reference: 8) Mancini ML, Sonis ST. Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities. Front Pharmacol 5, 51, 2014. doi: 10.3389/fphar.2014.00051. – reference: 3) Gouldin ED, Mullin C, Morges M, Mehler SJ, de Lorimier L-P, Oakley C, Risbon R, May L, Kahn SA, Clifford C. Feline discrete high-grade gastrointestinal lymphoma treated with surgical resection and adjuvant CHOP-based chemotherapy: retrospective study of 20 cases. Vet Comp Oncol 15, 328–335, 2017. doi: 10.1111/vco.12166. – reference: 2) Bernardo Marques G, Ponce F, Beaudu-Lange C, Béguin J, Boissy L, Chavalle T, Denoeux P, Diop N, Ferro L, Floch F, Lajoinie M, Sayag D, Barrett LE, Chamel G. Feline high-grade and large granular lymphocyte alimentary lymphomas treated with COP- or CHOP-based chemotherapy: A multi-centric retrospective study of 57 cases. Vet Comp Oncol 22, 186–197, 2024. doi: 10.1111/vco.12965. – reference: 10) Tan IJ-W, Tan K-K. A rare case of ileocecal valve stricture. Gastroenterology 159, e14–e15, 2020. doi: 10.1053/j.gastro.2020.04.024. – reference: 7) Kwak D-H, Cho M-J, Park H-J, Song K-H, Seo K-W. A retrospective study of 16 cats with intermediate- to high-grade alimentary lymphoma. Korean journal of veterinary research 61, e8, 2021. doi :10.14405/kjvr.2021.61.e8. – reference: 4) He Z, Zhang S. Tumor-associated macrophages and their functional transformation in the hypoxic tumor microenvironment. Front Immunol 12, 741305, 2021. doi: 10.3389/fimmu.2021.741305. |
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| Title | Post-chemotherapy intestinal fibrotic stricture in a cat with high-grade intestinal lymphoma |
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