PHARMACOKINETICS IN THE CEREBROSPINAL FLUID AFTER SIMULTANEOUS ADMINISTRATION OF LATAMOXEF AND AMPICILLIN TO RABBITS WITH STAPHYLOCOCCAL MENINGITIS

• Published in: Japanese journal of antibiotics Vol. 37; no. 9; pp. 1637 - 1646
• Main Authors: OKURA, KAN-ETSU, HARUTA, TSUNEKAZU, KOBAYASHI, YUTAKA
• Format: Journal Article
• Language: English
• Published: Japan Japan Antibiotics Research Association 01.09.1984
• Subjects: Ampicillin - administration & dosage; Ampicillin - cerebrospinal fluid; Animals; Drug Therapy, Combination; Injections, Intravenous; Kinetics; Meningitis - metabolism; Moxalactam - administration & dosage; Moxalactam - cerebrospinal fluid; Rabbits; Staphylococcal Infections - metabolism; Time Factors

The transfer of intravenously-administered latamoxef (moxalactam; LMOX) into the cerebrospinal fluid (CSF) is excellent and the usefulness of LMOX in the treatment of meningitis caused by Gramnegative bacilli has already been well established1-13). Because LMOX has weak activity against Gram-positiv...