慢性肝疾患における末梢血単球の免疫応答に関する研究-I領域関連抗原陽性単球
慢性肝疾患における末梢血単球のI領域関連抗原(Ia抗原)陽性細胞数を,モノクローナル抗体を用いた蛍光抗体間接法で測定した.Ia抗原陽性単球数は,慢性活動性肝炎と慢性非活動性肝炎では健常人と差は認められなかった.しかし亜小葉性肝壊死を伴う慢性肝炎,肝硬変および肝細胞癌では,健常人に比較し有意に減少していた(p<0.005).またIa抗原陽性単球数は副腎皮質ホルモン療法により減少したが,インターフェロン療法では変化しなかった.以上の成績より,亜小葉性肝壊死を伴なう慢性肝炎,肝硬変および肝細胞癌は抗原提示細胞の減少を認め,免疫応答の低下が示唆された.またIa抗原の表出は,副腎皮質ホルモンにより...
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| Published in | 肝臓 Vol. 27; no. 7; pp. 924 - 933 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本肝臓学会
1986
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.27.924 |
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| Abstract | 慢性肝疾患における末梢血単球のI領域関連抗原(Ia抗原)陽性細胞数を,モノクローナル抗体を用いた蛍光抗体間接法で測定した.Ia抗原陽性単球数は,慢性活動性肝炎と慢性非活動性肝炎では健常人と差は認められなかった.しかし亜小葉性肝壊死を伴う慢性肝炎,肝硬変および肝細胞癌では,健常人に比較し有意に減少していた(p<0.005).またIa抗原陽性単球数は副腎皮質ホルモン療法により減少したが,インターフェロン療法では変化しなかった.以上の成績より,亜小葉性肝壊死を伴なう慢性肝炎,肝硬変および肝細胞癌は抗原提示細胞の減少を認め,免疫応答の低下が示唆された.またIa抗原の表出は,副腎皮質ホルモンにより抑制されたが,外因性インターフェロンには影響されなかった. |
|---|---|
| AbstractList | 慢性肝疾患における末梢血単球のI領域関連抗原(Ia抗原)陽性細胞数を,モノクローナル抗体を用いた蛍光抗体間接法で測定した.Ia抗原陽性単球数は,慢性活動性肝炎と慢性非活動性肝炎では健常人と差は認められなかった.しかし亜小葉性肝壊死を伴う慢性肝炎,肝硬変および肝細胞癌では,健常人に比較し有意に減少していた(p<0.005).またIa抗原陽性単球数は副腎皮質ホルモン療法により減少したが,インターフェロン療法では変化しなかった.以上の成績より,亜小葉性肝壊死を伴なう慢性肝炎,肝硬変および肝細胞癌は抗原提示細胞の減少を認め,免疫応答の低下が示唆された.またIa抗原の表出は,副腎皮質ホルモンにより抑制されたが,外因性インターフェロンには影響されなかった. |
| Author | 山下, 善正 |
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| References | 8) Snyder DS, Lu CY, Unanue ER: Control of macrophages Ia expression in neonatal micerole of a splenic suppressor cell. J Immunol 128: 1458-1465, 1982 1) 山下善正:慢性肝疾患における末梢血単球の免疫応答機能に関する研究-細胞芽球化補助能と抑制マクロファージ活性について.肝臓 16) Basham T, Smith W, Lanier L: Regulation of expression of class II major histocompatibility antigens on human peripheral blood monocytes and Langerhans cells by interferon. Human Immunol 10: 83-93, 1984 2) Rosenthal AS, Shevach EM: Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J Exp Med 138: 1194-1212, 1973 3) Schwartz RH, David CS, Sachs DH: T lymphocyte-enriched murine peritoneal exudate cells. Inhibition of antigen-induced T lymphocyte proliferation with anti-Ia antisera. J Immunol 117: 531-540, 1976 11) Sherlock S: Hepatic cirrhosis. In: Diseases of the liver and biliary system, Edited by Sherlock S. 6, Blackwell, London, 1981, p323-333 9) Steeg PS, Johnson HM, Oppenheim JJ: Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: Inhibitory effect of endotoxin. J Immunol 129: 2402-2406, 1982 5) Shen HH, Talle MA, Goldstein G: Functional subsets of human monocytes defined by monoclonal antibodies: A distinct subset of monocytes contains the cells capable inducing the autologous mixed lymphocyte culture. J Immunol 130: 698-705, 1983 10) Yem AW, Parmely MJ: Modulation of Ia-like antigen expression and antigen-presenting activity of human monocytes by endotoxin and zymosan A.J Immunol 127: 2245-2251, 1981 12) 恩地森一,狩山美幸,山下善正,他:合成基質発色定量法による肝疾患患者血中エンドトキシンの測定.エンドトキシンの基礎と臨床,1985 6) 三浦正明,樋渡信夫,後藤由夫,他:炎症性腸疾患におけるサイトカイン産生能.消化器と免疫12:113-116, 1984 14) Snyder DS, Unanue ER: Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J Immunol 129: 1803-1805,1982 4) Unanue ER: Macrophages in antigenic stimulation. In: Advances in immunology 31, Academic Press, New York, 1981, p1-136 13) Smith BR, Ault KA: Increase of surface Ia like antigen expression on human monocytes independent of antigenic stimuli. J Immunol 127: 2020-2027, 1981 7) Gilman SC, Rosenberg JS, Feldman JD: Inhibition of interleukin syntheses and T cell proliferation by a monoclonal anti-Ia antibody. J Immunol 130: 1236-1240, 1983 15) Kelley VE, Fiers W, Storom TB: Cloned human interferon-γ, but not interferon-α or-β, induces expression of HLA-DR determinats by fetal monocytes and myeloid leukemia cell lines. J Immunol 132: 240-245, 1984 |
| References_xml | – reference: 11) Sherlock S: Hepatic cirrhosis. In: Diseases of the liver and biliary system, Edited by Sherlock S. 6, Blackwell, London, 1981, p323-333 – reference: 8) Snyder DS, Lu CY, Unanue ER: Control of macrophages Ia expression in neonatal micerole of a splenic suppressor cell. J Immunol 128: 1458-1465, 1982 – reference: 9) Steeg PS, Johnson HM, Oppenheim JJ: Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: Inhibitory effect of endotoxin. J Immunol 129: 2402-2406, 1982 – reference: 14) Snyder DS, Unanue ER: Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J Immunol 129: 1803-1805,1982 – reference: 6) 三浦正明,樋渡信夫,後藤由夫,他:炎症性腸疾患におけるサイトカイン産生能.消化器と免疫12:113-116, 1984 – reference: 12) 恩地森一,狩山美幸,山下善正,他:合成基質発色定量法による肝疾患患者血中エンドトキシンの測定.エンドトキシンの基礎と臨床,1985 – reference: 7) Gilman SC, Rosenberg JS, Feldman JD: Inhibition of interleukin syntheses and T cell proliferation by a monoclonal anti-Ia antibody. J Immunol 130: 1236-1240, 1983 – reference: 10) Yem AW, Parmely MJ: Modulation of Ia-like antigen expression and antigen-presenting activity of human monocytes by endotoxin and zymosan A.J Immunol 127: 2245-2251, 1981 – reference: 13) Smith BR, Ault KA: Increase of surface Ia like antigen expression on human monocytes independent of antigenic stimuli. J Immunol 127: 2020-2027, 1981 – reference: 3) Schwartz RH, David CS, Sachs DH: T lymphocyte-enriched murine peritoneal exudate cells. Inhibition of antigen-induced T lymphocyte proliferation with anti-Ia antisera. J Immunol 117: 531-540, 1976 – reference: 16) Basham T, Smith W, Lanier L: Regulation of expression of class II major histocompatibility antigens on human peripheral blood monocytes and Langerhans cells by interferon. Human Immunol 10: 83-93, 1984 – reference: 2) Rosenthal AS, Shevach EM: Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J Exp Med 138: 1194-1212, 1973 – reference: 15) Kelley VE, Fiers W, Storom TB: Cloned human interferon-γ, but not interferon-α or-β, induces expression of HLA-DR determinats by fetal monocytes and myeloid leukemia cell lines. J Immunol 132: 240-245, 1984 – reference: 5) Shen HH, Talle MA, Goldstein G: Functional subsets of human monocytes defined by monoclonal antibodies: A distinct subset of monocytes contains the cells capable inducing the autologous mixed lymphocyte culture. J Immunol 130: 698-705, 1983 – reference: 4) Unanue ER: Macrophages in antigenic stimulation. In: Advances in immunology 31, Academic Press, New York, 1981, p1-136 – reference: 1) 山下善正:慢性肝疾患における末梢血単球の免疫応答機能に関する研究-細胞芽球化補助能と抑制マクロファージ活性について.肝臓 |
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| SubjectTerms | I領域関連抗原陽性単球 インターフェロン 免疫応答 副腎皮質ホルモン 慢性肝疾患 |
| Title | 慢性肝疾患における末梢血単球の免疫応答に関する研究-I領域関連抗原陽性単球 |
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