Ca2+-induced Ca2+ Release from Internal Stores in INS-1 Rat Insulinoma Cells

• Published in: The Korean journal of physiology & pharmacology Vol. 15; no. 1; pp. 53 - 59
• Main Authors: Choi, Kyung Jin, Cho, Dong Su, Kim, Ju Young, Kim, Byung Joon, Lee, Kyung Moo, Kim, Shin Hye, Kim, Dong Kwan, Kim, Se Hoon, Park, Hyung Seo
• Format: Journal Article
• Language: English
• Published: The Korean Physiological Society and The Korean Society of Pharmacology 01.02.2011
• Subjects: Original

The secretion of insulin from pancreatic β-cells is triggered by the influx of Ca 2+ through voltage-dependent Ca 2+ channels. The resulting elevation of intracellular calcium ([Ca 2+ ] i ) triggers additional Ca 2+ release from internal stores. Less well understood are the mechanisms involved in Ca...